Cohesin News and Research

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Cohesin is the protein responsible for binding the sister chromatids during mitosis after S phase. At metaphase, most cohesin is removed, except for some at the centromere. At Anaphase, securin, an inhibitory subunit of separase, is hydrolyzed.

MGH researchers uncover new clues about X chromosome inactivation

Researchers at Massachusetts General Hospital have uncovered new clues that add to the growing understanding of how female mammals, including humans, "silence" one X chromosome.

15 Mar 2021

Researchers reveal how bacteria adhere to cellulose fibers in the gut

Researchers have revealed a new molecular mechanism by which bacteria adhere to cellulose fibers in the human gut. Thanks to two different binding modes, they can withstand the shear forces in the body.

28 Aug 2020

Study sheds new light on mechanisms of cohesin function involved in cancer and cardiac development

Ana Losada, from the Spanish National Cancer Research Centre (CNIO), is the scientist who identified cohesin in vertebrates, a protein that is essential in cell division.

12 Aug 2020

Researchers identify new protein complex that regulates chromosome separation

Researchers from the University of Tsukuba have identified a novel protein complex that regulates Aurora B localization to ensure that chromosomes are correctly separated during cell division

26 Jun 2020

Persistent DNA damage in the placenta can affect embryonic growth

Scientists at the Stowers Institute for Medical Research have shown that a dysfunctional placenta can play a previously unrecognized role during the earliest stages of development in mouse models of Cornelia de Lange syndrome.

16 Jun 2020

New mechanism for repair of chromosomal breaks

Chromosomal breaks are the most harmful damage for cells. If they are not repaired, they block the duplication and segregation of chromosomes, stop the growth cycle and cause cell death. These breaks appear frequently in tumor cells and are produced spontaneously during the replication of genetic material.

10 Feb 2020

New discovery on chromosomal function may shed light on human health and disease

Researchers have discovered key mechanisms and structural details of a fundamental biological process - how a cell nucleus and its chromosomal material reorganizes itself after cell division

5 Dec 2019

Study shows how the immune system achieves antibody diversity

Diversity is good, especially when it comes to antibodies. It's long been known that a gene assembly process called V(D)J recombination allows our immune system to mix and match bits of genetic code, generating new antibodies to conquer newly encountered threats.

15 Sep 2019

First extensive analysis of proteins in patients with acute lymphoblastic leukemia

The most common form of childhood cancer is acute lymphoblastic leukemia. Researchers at Lund University in Sweden, in cooperation with Karolinska Institutet, SciLifeLab and the University of Cambridge, have now carried out the most extensive analysis to date of ALL at the protein level, by studying the activity in over 8 000 genes and proteins.

25 Apr 2019

New study correlates 80 cancer-related gene mutations with 34 AML subgroups

A large, new study of adults with acute myeloid leukemia (AML) correlates 80 cancer-related gene mutations with five subtypes of AML, which are defined by the presence of specific chromosomal abnormalities. The findings might help guide mutation testing and treatment decisions in the future.

21 Mar 2017

Researchers elucidate how cells are blind to chromosome cohesion defects

Research led by Raquel Oliveira, group leader at Instituto Gulbenkian de Ciência, has elucidated how cells are almost blind to chromosome cohesion defects.

24 Mar 2016

Four key genes govern growth, multiplication of blood stem cells

An important element in getting blood stem cells to multiply outside the body is to understand which of the approximately 20,000 genes in the human body control their growth. Now a research team at Lund University in Sweden has studied close to 15,000 of these genes alongside each other.

22 Mar 2016

New zebrafish study provides insights into causes of congenital heart defects

Researchers working with zebrafish at New Zealand's University of Otago have published a study providing new insights into the causes of the congenital heart defects associated with a rare developmental disorder.

16 Oct 2015

CHOPS syndrome sheds light on key biological processes during human development

Analyzing a puzzling multisystem disorder in three children, genetic experts have identified a new syndrome, shedding light on key biological processes during human development. The research also provides important information to help caregivers manage the disorder, and may offer clues to eventually treating it.

3 Mar 2015

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting innovative early career researchers, named 15 new Damon Runyon Fellows at its fall Fellowship Award Committee review. The recipients of this prestigious, four-year award are outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators across the country.

31 Jan 2015

New study reveals mechanism that compromises chromosome stability

During cell division, chromosomes acquire a characteristic X-shape with the two DNA molecules (sister chromatids) linked at a central "connection region" that contains highly compacted DNA.

9 Oct 2014

Study: Cohesin mutations are common in melanoma and bladder cancer

Massive sequencing of cancer genomes brings to light new genes every day that could be involved in the process of tumour formation.

25 Jun 2014

Study: Pds5 proteins modulate behavior of cohesins to ensure proper division of cells

Cohesins are protein complexes that join the two copies of each chromosome-called sister chromatids-to ensure that they are shared fairly between the daughter cells during cell division. In this way, each daughter cell receives exactly the same genetic information from the parent cell.

19 Oct 2013

Researchers find possible mechanism of how cellular memory works

The DNA in human cells is translated into a multitude of proteins required for a cell to function. When, where and how proteins are expressed is determined by regulatory DNA sequences and a group of proteins, known as transcription factors, that bind to these DNA sequences.

16 Aug 2013

Findings set the stage for identifying potential new drug targets, treatment strategies for AML

nvestigators for The Cancer Genome Atlas Research Network have detailed and broadly classified the genomic alterations that frequently underlie the development of acute myeloid leukemia, a deadly cancer of the blood and bone marrow.

2 May 2013