Endothelin News and Research

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Endothelins are proteins that constrict blood vessels and raise blood pressure. They are normally kept in balance by other mechanisms, but when they are over-expressed, they contribute to high blood pressure (hypertension) and heart disease.

Are men or women impacted more by adverse reactions to prescription drug treatments?

Recently, researchers presented an overview of sex-based differences in adverse drug reactions (ADRs) based on epidemiology, technique, and underlying mechanism data.

11 Oct 2022

Midgestation increase in leptin puts child and mother at risk of cardiovascular disease

Before a baby is ever born, critical supply chain problems with nutrition and oxygen can result in premature birth or even death and increase the child and mother's lifelong risk of cardiovascular disease.

23 Jun 2022

Progressive exercise training mitigates negative effects of adverse childhood experiences in young women

New research shows a progressive exercise training program mitigates some physiological and psychological effects of adverse childhood experiences (ACE) in otherwise healthy young women.

2 Apr 2022

Cardiovascular markers for predicting clinical outcomes in SARS-CoV-2 infection

In a recent study posted to the medRxiv* preprint server, an interdisciplinary team of researchers from Toronto, Canada, characterized the markers of endothelial function and developed micro ribonucleic acid (miRNA) expression atlas in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive and -negative patients admitted to the intensive care unit (ICU).

15 Feb 2022

Study shows risk of MIS-C post mRNA vaccination against COVID-19 in children with autoimmune complications

Researchers discuss two cases of MIS-V after the patients had received the SARS-CoV-2 vaccine from Pfizer/BioNTech (BNT162b2).

23 Nov 2021

Pulmonary hypertension drug may become a treatment option for cancer

A drug used to treat pulmonary hypertension significantly reduced the capacity of tumor cells to migrate and invade other tissues in trials involving pancreatic, ovarian, breast cancer, and leukemia cell lines.

15 Dec 2020

Study determines mechanisms underlying abnormal development of nervous system in Hirschsprung disease

Ankush Gosain, MD, PhD, of Le Bonheur Children's Hospital and the University of Tennessee Health Science Center has focused his research on determining the mechanisms underlying abnormal development of the enteric nervous system in Hirschsprung disease.

14 Oct 2020

Researchers identify risk gene for Alzheimer's development

Researchers from the University of British Columbia and the Central South University in China have for the first time identified a gene that increases the risk of Alzheimer's disease.

1 Apr 2020

Some skin cancers originate in hair follicles, says new study

A new study published online in Nature Communicationson November 4, 2019, reports that some melanomas, which are among the deadliest skin cancers, originate in melanocyte stem cells that are located within the hair follicles.

4 Nov 2019

Some deadly skin cancers may originate in hair follicles

Some deadly skin cancers may originate in the pigment-making stem cells in hair follicles rather than in skin.

4 Nov 2019

Some skin cancers may originate in hair follicles

Some of the most deadly skin cancers may start in stem cells that lend color to hair, and originate in hair follicles rather than in skin layers, a new study finds.

4 Nov 2019

Study pinpoints immune cells that could be key to tackling hypertension

Scientists have pinpointed cells in the immune system that could be key to tackling high blood pressure.

16 Jan 2019

Conference to focus on preventing and reversing consequences of sickle cell disease

Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American Physiological Society, will explore SCD- the world's most prevalent single-gene mutation disease - and new research on preventing and reversing its deadly consequences.

1 Nov 2017

Drug treatment used for other conditions can help women combat urinary incontinence

Urinary incontinence in women is common, with almost 50% of adult women experiencing leakage at least occasionally. Genetic or heritable factors are known to contribute to half of all cases, but until now studies had failed to identify the genetic variants associated with the condition.

29 May 2017

Reducing cocaine use can potentially reverse coronary atherosclerosis

People who use cocaine regularly are at high risk of coronary artery disease. A study in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine, reports that stopping or reducing cocaine use can potentially reverse the process of coronary atherosclerosis. The journal is published by Wolters Kluwer.

12 Jan 2017

Vitamin B3 may help treat preeclampsia-affected pregnant women

Scientists in Japan and the US have found that vitamin B3 nicotinamide may help treat pregnant women who suffer from preeclampsia by preventing strokes and in some cases, even stimulating the growth of their fetus.

15 Dec 2016

Results of high-impact clinical trials could improve kidney-related medical care

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented at ASN Kidney Week 2016, November 15-20 at McCormick Place in Chicago, IL.

21 Nov 2016

No added benefit proven for pulmonary arterial hypertension drug, IQWiG finds

Selexipag is approved for long-term treatment of pulmonary arterial hypertension (PAH) in adults with moderate to severe symptoms.

7 Oct 2016

Study reveals promising strategy against bladder cancer metastasis

The popular kids' card game "Exploding Kittens" teaches a concept critical to cancer science: When a player plays a "Nope" card, the subsequent player may lay another "Nope", thus creating a double-negative that becomes a positive, allowing the initial action to proceed.

12 Sep 2016

GPCR-Gβγ inhibition therapy could prevent chronic and acute kidney damage in heart failure patients

A study in the Journal of the American Society of Nephrology suggests a new therapeutic approach to treat the development of chronic kidney disease secondary to chronic heart failure, known as cardiorenal syndrome type 2.

14 Jun 2016

Endothelin News and Research

Are men or women impacted more by adverse reactions to prescription drug treatments?

Midgestation increase in leptin puts child and mother at risk of cardiovascular disease

Progressive exercise training mitigates negative effects of adverse childhood experiences in young women

Cardiovascular markers for predicting clinical outcomes in SARS-CoV-2 infection

Study shows risk of MIS-C post mRNA vaccination against COVID-19 in children with autoimmune complications

Pulmonary hypertension drug may become a treatment option for cancer

Study determines mechanisms underlying abnormal development of nervous system in Hirschsprung disease

Researchers identify risk gene for Alzheimer's development

Some skin cancers originate in hair follicles, says new study

Some deadly skin cancers may originate in hair follicles

Some skin cancers may originate in hair follicles

Study pinpoints immune cells that could be key to tackling hypertension

Conference to focus on preventing and reversing consequences of sickle cell disease

Drug treatment used for other conditions can help women combat urinary incontinence

Reducing cocaine use can potentially reverse coronary atherosclerosis

Vitamin B3 may help treat preeclampsia-affected pregnant women

Results of high-impact clinical trials could improve kidney-related medical care

No added benefit proven for pulmonary arterial hypertension drug, IQWiG finds

Study reveals promising strategy against bladder cancer metastasis

GPCR-Gβγ inhibition therapy could prevent chronic and acute kidney damage in heart failure patients

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