Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Timing of regenerative cues may be key to better healing from injury

For decades, medicine has chased a simple but elusive goal of delivering the right drug to the right place at the right time.

16 Jul 2026

AI model predicts effective immunotherapy combinations for liver cancer

Using computational tools, researchers from the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a method to predict which patients with a primary liver cancer called hepatocellular carcinoma (HCC) would most benefit from combination treatment using immunotherapy and a targeted therapy that blocks the growth signals that the tumor depends on.

15 Jul 2026

New bionic skin wound dressing accelerates infected tissue healing

Dressings face a critical limitation: no single product has successfully integrated protective function, wearing comfort, and efficient antibacterial activity.

11 Jul 2026

Cosmetic microneedles deliver actives where creams struggle

This review shows how microneedle-based cosmetic systems bypass the stratum corneum to deliver poorly penetrating actives, including peptides, retinoids, vitamins, niacinamide, hyaluronic acid, and hair-growth compounds, into viable skin layers.

8 Jul 2026

Smart nanoplatform uses wound acidity to trigger accelerated healing

Infected wounds pose a significant medical challenge, often leading to delayed healing and complications due to bacterial biofilms and excessive inflammation.

26 Jun 2026

Study identifies key fibrotic cells driving hypertrophic scars

Hypertrophic scars (HS) are abnormal outcomes of wound healing, marked by excessive extracellular matrix (ECM) deposition and impaired scar remodeling.

25 Jun 2026

Modulating pathogenic scar cells promotes spinal cord regeneration

SCI often causes long-term motor and sensory deficits because the damaged tissue does not simply heal like many peripheral tissues.

24 Jun 2026

Researchers uncover key mechanism driving chronic Sjögren disease

Sjögren disease, an autoimmune disease characterized by dry mouth and dry eyes, may reduce patients’ quality of life.

24 Jun 2026

Researchers identify molecular pathway that delays diabetic wound healing

Diabetic foot ulcer (DFU) is one of the most serious complications of diabetes and a major cause of lower-limb amputation.

23 Jun 2026

Machine learning identifies natural compound to treat lung disease

A new study published in Engineering has combined machine learning (ML) and experimental validation to identify dihydromyricetin (DHM), a natural flavonoid, as a potent inhibitor of the TGF-β/ALK5 signaling cascade with therapeutic potential for idiopathic pulmonary fibrosis (IPF).

16 Jun 2026

Bionic cooling skin accelerates healing and combats wound infections

As the global burden of infected wounds continues to rise-with over 300 million surgeries performed annually and postoperative infections affecting 5–20% of patients-conventional wound dressings face a critical limitation: no single product has successfully integrated protective function, wearing comfort, and efficient antibacterial activity.

15 Jun 2026

Tumor microenvironment drives drug resistance in lung cancer subtypes

A study by the University of Barcelona has discovered why the two main types of lung cancer — adenocarcinoma of the lung and squamous cell carcinoma — respond differently to anti-angiogenic therapy, that is, drugs that block the formation of new blood vessels that tumors need in order to grow.

15 Jun 2026

Single-dose gene therapy extends healthy lifespan in older mice

A research team from the Universitat Autònoma de Barcelona (UAB) has shown that a one-time administration of a gene therapy expressing the metabolic factor FGF21 can prolong health span in old mice.

15 Jun 2026

Review outlines virtual tumor concept and next-generation immunotherapy

A comprehensive review led by Associate Researcher Linnan Zhu and Academician Zemin Zhang at Biomedical Pioneering Innovation Center (BIOPIC), Peking University, China, and Chongqing Medical University, China, was published in Volume 2, article number 27 of the journal Immunity & Inflammation on June 05, 2026.

12 Jun 2026

New topical gel uses repurposed MS drug to heal burns

Researchers at the Terasaki Institute for Biomedical Innovation and the University of Arizona College of Medicine have developed a topical gel formulation with 4-aminopyridine (4-AP), to treat burn wounds, achieving near-complete closure in 21 days.

4 Jun 2026

Mesenchymal drift may explain how aging cells lose their identity

Mesenchymal drift may help explain how cells lose stable identity and acquire pro-fibrotic, inflammatory mesenchymal traits during aging. The review proposes MD as a unifying framework that links multiple hallmarks of aging and highlights partial reprogramming as a potential, but still preclinical, way to counteract this process.

1 Jun 2026

Lactylation may drive pulmonary fibrosis through metabolic reprogramming pathways

Announcing a new article publication in BIO Integration. Pulmonary fibrosis (PF) is a progressive and irreversible interstitial lung disease that is characterized by destruction of alveolar architecture, excessive proliferation of fibroblasts, and aberrant deposition of extracellular matrix (ECM) but the precise pathogenesis has yet to be fully elucidated.

27 May 2026

New study tests vitamin D analog against pancreatic cancer

A small clinical trial led by Dana-Farber Cancer Institute researchers put a Salk Institute idea to the test in patients: that activating the vitamin D receptor can help reshape the protective environment surrounding pancreatic tumors in ways that could make the notoriously difficult-to-treat cancer more vulnerable to therapeutic treatments.

26 May 2026

Roswell Park scientists present five key cancer studies at clinical meeting

The research findings of experts from Roswell Park Comprehensive Cancer Center will be featured during the American Society of Clinical Oncology (ASCO) annual meeting May 29 to June 2 at McCormick Place in Chicago.

25 May 2026

Scientists reveal why common pancreatic precancer lesions rarely turn deadly

Spatial and single-cell analyses of human donor pancreata showed that PanIN epithelial cells gradually acquire cancer-like molecular features, while their surrounding stromal and immune environment remains closer to normal pancreatic tissue. The findings suggest that delayed or incomplete microenvironmental reprogramming may help explain why most PanIN lesions remain indolent rather than progressing to pancreatic cancer.

24 May 2026