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Landmark RSI trial reshapes sedative selection for emergency airway management

Doctors treating seriously ill patients in an emergency setting may want to give the sedative etomidate, rather than ketamine, while placing a breathing tube, according to a randomized trial published in the New England Journal of Medicine.

9 Dec 2025

Generative AI aids discovery of ISM3830's novel scaffold

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, playing a central role in modulating T-cell activation and immune tolerance, and its inhibition enhances T cells and NK cells function, also provides a strategy for the function restoration of exhausted T cells.

1 Dec 2025

Dash diet cuts diabetes complications by targeting blood pressure kidney health and inflammation

The DASH diet supports metabolic health in people with diabetes by improving blood pressure, renal function, lipids, and modest glycemic markers while reducing risks linked to vascular and inflammatory pathways. Its broad nutrient-driven mechanisms also benefit related conditions such as neuropathy, PCOS, and retinopathy, making it a versatile tool for cardiometabolic care.

16 Nov 2025

Research shows Sudan Ebola's lasting impact and potential for mother-to-child transmission

More than half of survivors of the Sudan Ebola virus still suffer serious health problems two years post-infection and the virus can persist in semen and breast milk for months after recovery, according to the first study examining the virus's long-term effects.

3 Oct 2025

Implantable device helps stabilize blood pressure in spinal cord injury patients

Getting out of bed in the morning without the risk of passing out is a game-changer for 32-year-old Cody Krebs.

17 Sep 2025

Ketogenic diets may lower migraine frequency and medication use

This narrative review argues that the migraine brain is hypometabolic, with converging evidence of mitochondrial dysfunction, impaired glucose handling, neuroinflammation, microbiome shifts, and obesity-related pathways. It proposes ketogenic diets as a plausible preventive strategy that may reduce monthly migraine days and medication use, while emphasizing the need for larger, rigorous randomized trials and careful clinical oversight.

14 Sep 2025

In-hospital start of dapagliflozin shows no significant short-term benefit in heart failure patients

In-hospital initiation of dapagliflozin did not significantly reduce the short-term risk of cardiovascular death or worsening heart failure (HF) in patients admitted for HF, although positive effects were seen when combining trial data, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Ivabradine fails to prevent myocardial injury after noncardiac surgery in large clinical trial

Ivabradine did not reduce the occurrence of myocardial injury after noncardiac surgery (MINS), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Phase II trial finds zilebesiran lowers systolic blood pressure in patients with uncontrolled hypertension

Among individuals with cardiovascular disease or high cardiovascular risk and uncontrolled hypertension on multiple anti-hypertensive agents, a single subcutaneous dose of zilebesiran 300 mg led to a 5-mmHg reduction in systolic blood pressure at Month 3 compared with placebo, a difference that did not reach statistical significance.

1 Sep 2025

Rethinking chronic disease management in older adults

Effectively managing chronic conditions like diabetes and hypertension can greatly improve quality of life, reduce complications and extend longevity for older adults.

20 Aug 2025

Aggressive blood pressure management offers greater health benefits

Research led by investigators at Mass General Brigham suggests that the health benefits of more aggressive blood pressure control outweigh concerns about overtreating people with high blood pressure readings. Results of the simulation study are published in Annals of Internal Medicine.

19 Aug 2025

Addressing avoidable hospitalizations in terminally ill nursing home residents

Hospitalizations and emergency department (ED) visits can be distressing and costly for nursing home residents – especially those who are severely impaired or terminally ill. Despite their vulnerability, these individuals are frequently transferred to hospitals, even though up to 40% of such transfers over the past 25 years are considered potentially avoidable by health care professionals.

25 Jul 2025

New guidance helps GPs manage patients using weight loss drugs

Academics at King's College London and the University of East Anglia have released guidance for GPs on how to manage patients who may be privately accessing weight loss drugs.

25 Jun 2025

ADC189 shows promise as a single-dose treatment for influenza

Influenza continues to pose a significant global health burden, with seasonal outbreaks causing substantial morbidity and mortality.

24 Jun 2025

PDE3 inhibitors show promise in promoting bone growth

Bone growth occurs through the proliferation of specialized cells of the cartilage tissue, known as chondrocytes, on either end of a bone.

17 Jun 2025

Two blood pressure management strategies yield similar cognitive outcomes after non-cardiac surgery

A large international study has found that two different approaches to managing blood pressure in older adults undergoing non-cardiac surgery, one avoiding low blood pressure (hypotension) and the other high blood pressure (hypertension), lead to similar outcomes in terms of in-hospital delirium and cognitive changes one year after surgery.

4 Jun 2025

Guideline-directed medical therapy boosts survival in the oldest heart attack patients

Researchers have found that prescribing guideline-directed medical treatment (GDMT), regardless of the number of medications, can improve survival rates in patients 90 years of age and older following their first heart attack, with the greatest benefit observed in patients who received all four recommended post-acute myocardial infarction (AMI) therapies.

22 May 2025

Study: One in four early cardiogenic shock patients experience worse outcomes

In one of the largest studies of early cardiogenic shock (CS) patients, where blood flow is still functioning to vital organs, researchers demonstrated that 26% experienced worse outcomes, including care escalation, CS deterioration, or in-hospital mortality.

2 May 2025

Researchers create an atlas of health associations for GLP-1 receptor agonists

Insights from a study on GLP-1 receptor agonists reveal benefits for cardiometabolic health, with notable risks for gastrointestinal and musculoskeletal issues.

20 Jan 2025

New advisory offers evidence-based strategies to prevent postoperative delirium in older adults

Delirium and cognitive decline are common complications of anesthesia and surgery in older adults.

10 Dec 2024

Hypotension News and Research

Landmark RSI trial reshapes sedative selection for emergency airway management

Generative AI aids discovery of ISM3830's novel scaffold

Dash diet cuts diabetes complications by targeting blood pressure kidney health and inflammation

Research shows Sudan Ebola's lasting impact and potential for mother-to-child transmission

Implantable device helps stabilize blood pressure in spinal cord injury patients

Ketogenic diets may lower migraine frequency and medication use

In-hospital start of dapagliflozin shows no significant short-term benefit in heart failure patients

Ivabradine fails to prevent myocardial injury after noncardiac surgery in large clinical trial

Phase II trial finds zilebesiran lowers systolic blood pressure in patients with uncontrolled hypertension

Rethinking chronic disease management in older adults

Aggressive blood pressure management offers greater health benefits

Addressing avoidable hospitalizations in terminally ill nursing home residents

New guidance helps GPs manage patients using weight loss drugs

ADC189 shows promise as a single-dose treatment for influenza

PDE3 inhibitors show promise in promoting bone growth

Two blood pressure management strategies yield similar cognitive outcomes after non-cardiac surgery

Guideline-directed medical therapy boosts survival in the oldest heart attack patients

Study: One in four early cardiogenic shock patients experience worse outcomes

Researchers create an atlas of health associations for GLP-1 receptor agonists

New advisory offers evidence-based strategies to prevent postoperative delirium in older adults

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How Omics Technologies Are Transforming Biological Research and Drug Discovery

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