Large Intestine News and Research

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Gut hormone INSL5 linked to chronic diarrhea in patients with bile acid malabsorption

High levels of a hormone found in cells in the gut could underlie many cases of chronic diarrhea and help explain up to 40% of cases of patients with irritable bowel syndrome with diarrhea, according to a new study led by scientists at the University of Cambridge.

29 Jul 2025

Combination of dysbiosis, OTUD3 gene mutations, and STING signaling linked to ulcerative colitis severity

Ulcerative colitis (UC) causes misery for millions worldwide. It affects the large intestine, causing pain, cramping, and frequent bowel movements with bloody diarrhea.

18 Jul 2025

Unlocking bacterial genomes to develop tailored probiotic therapies

Probiotics are emerging tools used by neonatal intensive care units to promote healthy outcomes and prevent intestinal diseases such as necrotizing enterocolitis.

16 Jul 2025

Healthy lifestyle lowers risk of diverticulitis despite genetic susceptibility

Maintaining a healthy lifestyle-specifically, a diet rich in fibre but light on red/processed meat, regular exercise, not smoking, and sticking to a normal weight-is linked to a significantly lower risk of diverticulitis, finds a large long term study, published online in the journal Gut.

2 Jul 2025

CIK treatment enhances survival in early and advanced colorectal cancer

Colorectal cancer (CRC) is the second most common cause of death from cancer in the United States (US) and the most prevalent malignant tumor worldwide.

24 Jun 2025

Low FODMAP diet shown to improve gastrointestinal symptoms in women with endometriosis

A low FODMAP diet developed by Monash University researchers for irritable bowel syndrome (IBS) has been shown to improve gastrointestinal symptoms in women with endometriosis.

23 Jun 2025

New study warns of long-term risks from fecal microbiota transplants

Fecal microbiota transplants (FMT) have been touted as a potential treatment for a variety of conditions, from inflammatory bowel diseases, obesity, and type 2 diabetes to autism.

6 Jun 2025

Eating kombu daily enhances gut health and heart markers in men

A 12-week randomized trial found that daily intake of boiled kombu (Laminaria japonica) powder reduced body fat and raised adiponectin in Japanese men, while improving blood pressure and gut microbiota in both sexes. No significant effects were seen in women for body fat reduction or adiponectin.

20 May 2025

Acetate and gut bacteria work together to reduce obesity in mice

Researchers led by Hiroshi Ohno at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered a new way to reduce obesity.

19 May 2025

Five major advances in anal and rectal cancer treatment with radiotherapy: A new era of organ-preserving options

Rectal cancer is a type of bowel cancer that develops in the last several centimeters of the large intestine, just before the anus.

2 May 2025

Researchers analyze the mutational landscape of TMB-high colorectal cancer tumors

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide.

15 Apr 2025

High fiber diet helps protect against dangerous gut infections

A study published in the journal Cell Host & Microbe by Brazilian and American researchers suggests that a diet rich in soluble fiber can protect the intestine against pathogenic bacteria.

9 Apr 2025

Reprogramming the colon could be a therapeutic strategy for short bowel syndrome

Knocking out a single gene reprograms part of the large intestine to function like the nutrient-absorbing small intestine.

3 Apr 2025

Diagnostic colonoscopy follow-up unaffected by COVID-19 surge, despite screening delays

Two recent studies by researchers from Regenstrief Institute and the Indiana University School of Medicine explore the effect of the pandemic on colorectal cancer screening tests and diagnostic colonoscopies in Central Indiana. The findings of temporary disruption to the former and minimal impact on the latter are similar to findings across the U.S., contributing to the compendium of knowledge on preventive health uptake and subsequent treatment in various populations during the pandemic.

27 Mar 2025

Australian scientists redefine dietary fiber classification for better health benefits

Australian food scientists have reclassified dietary fibers – beyond just soluble and insoluble – to better guide nutritional decisions and drive targeted health food products.

19 Mar 2025

Restoring gut health in ulcerative colitis through microbiome-based therapy

The human gut is home to trillions of bacteria that play vital roles in digestion, immunity, and overall health.

10 Mar 2025

Study uncovers how glucose excreted in the gut converts into beneficial fatty acids

Gut microbes that were thought to feed exclusively on dietary fiber also get fed sugar from our guts, from which they produce short-chain fatty acids that are crucial to many body functions.

4 Mar 2025

The brain-gut microbiota axis: Impact on mental health & potential treatment avenues

To be decided by the editor

From Atlantia Clinical Trials 28 Feb 2025

Preventing colorectal cancer through lifestyle choices

The evidence is clear - screening for colorectal cancer may save one's life. Today, more and more people are choosing colorectal cancer screening. As a result, there is a steady decline in the number of older people getting and dying from colorectal cancer. Lower rates of smoking among Americans have also contributed to the decline in the past several years.

19 Feb 2025

New target identified for potential colorectal cancer treatment

Colorectal cancer (CRC) is a type of cancer that begins in the colon (large intestine) or rectum, which are parts of the digestive system.

15 Jan 2025