Melanoma Cells News and Research

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Nanoparticle vaccine shows promise in preventing multiple cancers in mice

A study led by University of Massachusetts Amherst researchers demonstrates that their nanoparticle-based vaccine can effectively prevent melanoma, pancreatic and triple-negative breast cancer in mice.

9 Oct 2025

Key protein found to guide melanoma cells during spread

Researchers have discovered a protein which is critical for steering melanoma cancer cells as they spread throughout the body.

1 Aug 2025

Melanoma’s excessive mitochondrial dependence becomes a therapeutic vulnerability

Researchers have discovered that the most aggressive melanomas, the deadliest form of skin cancer, overactivate two key processes in mitochondria, the components of cells that provide energy.

23 Jun 2025

Study reveals a unique vulnerability in melanoma patients with neurofibromin 1 mutations

Increased activity in a specific biological pathway may explain why many patients with a deadly form of skin cancer do not respond to the latest cancer treatments, a new study shows.

10 Jun 2025

Engineered viruses and gene therapy halt tumor growth and extend survival in mice

This study reveals the potential of engineered phage-IL-12 therapy in melanoma, enhancing immune response and tumor destruction in aggressive cancer models.

2 Jun 2025

Study reveals how PAX3 protein drives melanoma growth

PAX3 is a transcription factor (proteins involved in converting DNA into RNA) that drives melanoma progression by promoting cell growth, migration and survival, while inhibiting cellular terminal differentiation, which is the final stage where a cell becomes specialized and cell division ends.

19 May 2025

Research explores how photo-oxidized sterols kill melanoma cells

Melanoma is the most aggressive form of skin cancer. Although less common, it is the most serious due to its high potential for metastasis.

16 Apr 2025

Blood test for tumor DNA may predict melanoma recurrence

Monitoring blood levels of DNA fragments shed by dying tumor cells may accurately predict skin cancer recurrence, a new study shows.

15 Apr 2025

GSK3β identified as a driver of drug resistance in BRAF mutant melanoma

A new research perspective was published in Oncotarget, Volume 16, on April 4, 2025, titled "GSK3β activation is a key driver of resistance to Raf inhibition in BRAF mutant melanoma cells."

11 Apr 2025

Protein linked to Parkinson's also found to drive melanoma growth

A small protein involved in neurodegeneration leading to Parkinson's disease also drives a type of skin cancer known as melanoma, new research led by Oregon Health & Science University finds.

9 Apr 2025

New drug combination shows promise in treating melanoma brain metastasis

A federally funded research team led by Sheri Holmen, PhD, investigator at Huntsman Cancer Institute and professor in the Department of Surgery at the University of Utah (the U), is testing a new combination drug therapy that could both treat and prevent melanoma metastasis, or spreading from its original site, to the brain.

21 Mar 2025

Melanoma cells use stealth strategy to survive targeted therapy

Researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes.

20 Mar 2025

Targeted alpha therapy offers new hope for treating metastatic melanoma

Metastatic melanoma, also known as stage IV melanoma, is a type of skin cancer that spreads to other parts of the body.

12 Mar 2025

T cells grown with new technique offer better cancer defense

Researchers from the University of Pittsburgh have developed a new way to grow T cells in the lab that enables them to live longer and better destroy cancer cells in a mouse model of melanoma compared to those grown in traditional growth media.

28 Jan 2025

Researchers identify ferroptosis as driver of osteocyte death in melanoma metastasis

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain.

23 Jan 2025

Study shows how peptides from nature could combat melanoma drug resistance

Antimicrobial peptides derived from a crab and a spider may provide the pathway to overcoming drug resistance in advanced melanoma.

19 Dec 2024

Study points to a strategy for inhibiting hyper-progression of melanoma

Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma cells instead of unleashing the immune system to fight them.

25 Nov 2024

Researchers discover key protein interaction driving skin cancer growth

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.

22 Nov 2024

New test promises to end malaria

Almost half of the world's population is at risk of malaria infection, with children and pregnant women at the highest risk of getting sick and dying from the disease. Current methods to detect this potentially deadly infection rely on obtaining an invasive blood sample, and each test has significant limitations that restrict its utility.

29 Oct 2024

New insights into melanoma metastasis reveal potential drug target

Investigators from Weill Cornell Medicine have discovered a defense mechanism that protects skin cancer cells from oxidative stress and helps them spread.

22 Oct 2024