Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

CFHR1 could be a new diagnostic marker for IgA nephropathy

Immunoglobulin A (IgA) nephropathy is an autoimmune disease characterized by the deposition of circulating IgA-containing immune complexes (IgA-ICs) in the glomerular mesangium, leading to mesangial cell proliferation, enhanced extracellular matrix production, and variable infiltration of inflammatory cells.

30 Mar 2026

BNP predicts kidney disease progression risk in diabetes patients

The relationship between cardiovascular dysfunction and renal impairment is widely recognized as the cardiorenal interaction, a complex physiological link in which damage to one organ can accelerate deterioration in the other.

24 Mar 2026

Routine care gap leaves metabolic acidosis undetected in chronic kidney disease

A Japanese registry has identified a blind spot in the routine care of patients with chronic kidney disease (CKD). Serum bicarbonate levels are rarely measured, leaving metabolic acidosis largely undetected and hence, undertreated.

16 Mar 2026

Brain breathing mechanism linked to persistent high blood pressure

A brain mechanism may explain why approximately 40% of people with hypertension continue to have high blood pressure despite taking medication. The discovery reveals potential targets for new treatments.

16 Mar 2026

Early prenatal shunt treatment improves outcomes for fetal megacystis

An interdisciplinary team from the University Hospitals Cologne and Bonn have conducted the first prospective study to investigate whether very early intervention in unborn children with congenital lower urinary tract obstruction (cLUTO) can improve their chances of survival and subsequent kidney function.

13 Mar 2026

MERLIN algorithm unlocks immune cell location memory in organs

A new AI-based method reconstructs spatial information about where immune cells were originally located in an organ, even after these cells have been removed from the tissue and analyzed individually.

2 Mar 2026

New immunotherapy could replace daily pills after kidney transplantation

A new study offers hope that kidney transplant patients could one day have a monthly treatment instead of multiple pills every day.

3 Feb 2026

Scientists discover why patients with chronic kidney disease die of heart problems

Scientists have discovered an answer to the longstanding mystery of why more than half of patients with chronic kidney disease ultimately die of cardiovascular problems: Their kidneys produce a substance that poisons the heart.

20 Jan 2026

A single immune protein may help explain why kidney and heart disease often develop together

This review synthesizes clinical, genetic, and mechanistic evidence showing that suPAR and related uPAR fragments are strongly associated with kidney, cardiovascular, and metabolic disease risk. It highlights suPAR as a stable biomarker of innate immune activation with potential pathogenic roles, while underscoring major gaps in assay standardization and therapeutic validation.

6 Jan 2026

New atomic structure reveals how NBCn1 transporter protein aids breast cancer cell survival

UCLA scientists have characterized the structure and function of a key survival protein in breast cancer cells that helps explain how these tumors resist environmental stress and thrive in acidic, low-oxygen environments that would normally be toxic to healthy cells.

5 Dec 2025

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Researchers at Helmholtz Munich, the Technical University of Munich and the LMU University Hospital Munich uncovered a mechanism that protects nerve cells from premature cell death, known as ferroptosis.

4 Dec 2025

Chronic kidney disease accelerates cognitive decline through heart-brain pathways

A new study published in the American Journal of Physiology - Heart and Circulatory Physiology reveals that chronic kidney disease (CKD) accelerates cognitive decline through interconnected damage to the heart and brain-and that these pathways differ markedly between men and women.

4 Dec 2025

Culturally tailored intervention helps reduce interdialytic weight gain in kidney failure care

The intervention, called Navigate-Kidney, utilizes community health workers (CHWs) to help patients undergoing hemodialysis understand and work through challenges that come with treatment, including socioeconomic factors, particularly food insecurity as well as lack of culturally responsive care, and disparities in access to health insurance and health care.

24 Nov 2025

Study reveals the long-lasting health impacts of eating disorders

The health impacts of eating disorders, such as anorexia, bulimia, and binge eating, are not only complex, affecting many different organ systems, but long-lasting, finds a large tracking study, published in the open access journal BMJ Medicine.

19 Nov 2025

Revised ESE clinical guideline published for the management of hypoparathyroidism in adults

The European Society of Endocrinology (ESE) has published an open access Revised Clinical Practice Guideline for the Treatment of Chronic Hypoparathyroidism in Adults in the European Journal of Endocrinology, Volume 193, Issue 5, November 2025.

13 Nov 2025

New approach to kidney transplant listing could improve outcomes and equity

The current kidney transplant waitlisting criterion is based on a single measurement of kidney function (estimated glomerular filtration rate [eGFR] ≤20 ml/min/1.73m2) and does not consider an individual's risk of progressing to kidney failure.

13 Nov 2025

Texas' transitional dialysis program led to significant decline in utilization of emergency dialysis

The cost of emergency dialysis is estimated to be 8-times that of in-center dialysis. A new study reveals that a transitional dialysis program piloted in Travis County (Austin, TX) resulted in a significant decrease in emergency department visits and hospital admissions for emergency dialysis by providing a pathway for outpatient dialysis in uninsured patients.

10 Nov 2025

Expanding the waitlisting criteria for kidney transplantation could improve patient outcomes

The current kidney transplant waitlistingcriterion is based on a single measurement of kidney function (estimated glomerular filtration rate [eGFR] ≤20 ml/min/1.73m2) and does not consider an individual’s risk of progressing to kidney failure.

10 Nov 2025

New protocol developed for diagnosis and treatment of metformin-associated lactic acidosis

Metformin-associated lactic acidosis (MALA) is a rare but serious adverse effect of the diabetes drug metformin in which the body accumulates too much lactic acid. Investigators developed and tested a protocol for diagnosis and treatment of MALA.

10 Nov 2025

Using estimated risks and preferences to justify intensive BP control in CKD patients

An analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) indicates that nearly all adults with chronic kidney disease (CKD) would have benefits that outweigh the harm from a systolic blood pressure target of <120 mm Hg compared with a target of <140 mm Hg. The findings will be presented at ASN Kidney Week 2025 November 5– 9.

8 Nov 2025

Nephrology News and Research

Further Reading

CFHR1 could be a new diagnostic marker for IgA nephropathy

BNP predicts kidney disease progression risk in diabetes patients

Routine care gap leaves metabolic acidosis undetected in chronic kidney disease

Brain breathing mechanism linked to persistent high blood pressure

Early prenatal shunt treatment improves outcomes for fetal megacystis

MERLIN algorithm unlocks immune cell location memory in organs

New immunotherapy could replace daily pills after kidney transplantation

Scientists discover why patients with chronic kidney disease die of heart problems

A single immune protein may help explain why kidney and heart disease often develop together

New atomic structure reveals how NBCn1 transporter protein aids breast cancer cell survival

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Chronic kidney disease accelerates cognitive decline through heart-brain pathways

Culturally tailored intervention helps reduce interdialytic weight gain in kidney failure care

Study reveals the long-lasting health impacts of eating disorders

Revised ESE clinical guideline published for the management of hypoparathyroidism in adults

New approach to kidney transplant listing could improve outcomes and equity

Texas' transitional dialysis program led to significant decline in utilization of emergency dialysis

Expanding the waitlisting criteria for kidney transplantation could improve patient outcomes

New protocol developed for diagnosis and treatment of metformin-associated lactic acidosis

Using estimated risks and preferences to justify intensive BP control in CKD patients

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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