Oophorectomy News and Research

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Oophorectomy is the surgical removal of an ovary or ovaries. The surgery is also called ovariectomy, but this term has been traditionally used in basic science research describing the surgical removal of ovaries in laboratory animals.

Risk-reducing surgeries provide benefits for young BRCA-mutation carriers

Patients with germline BRCA mutations who were diagnosed with breast cancer at or before age 40 and who underwent a bilateral risk-reducing mastectomy (RRM) and/or a risk-reducing salpingo-oophorectomy (RRSO) had lower rates of recurrence, secondary breast and/or ovarian malignancies, and death than those who did not undergo these surgeries, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

11 Dec 2024

Early bilateral oophorectomy linked to increased Alzheimer's disease risk

Women with early bilateral oophorectomy face higher Alzheimer's risk, especially with APOE4 allele; education and hormone therapy may offer resilience.

9 Dec 2024

Early ovarian removal and APOE4 increase Alzheimer's risk in women

New research published by a team of researchers from the University of Toronto in collaboration with colleagues from the University of Alberta has found that women who have had both ovaries surgically removed before the age of 50 and carry a variant of the apolipoprotein gene, the APOE4 allele, are at high risk of late-life Alzheimer disease (AD). Use of hormone therapy mitigates this risk.

5 Dec 2024

History of endometriosis and fibroids linked to higher long-term risk of early death

Researchers examine the impact of endometriosis and uterine fibroids on the risk of early death.

25 Nov 2024

Hormonal treatment could delay biological aging among postmenopausal females

Hormone treatment in postmenopausal women is associated with lower biological aging discrepancies, particularly among those with lower socioeconomic status.

3 Sep 2024

Ovary removal before menopause could accelerate brain degeneration

Premenopausal bilateral oophorectomy (PBO) is linked to reduced white matter integrity in the brain, particularly in women who undergo PBO before the age of 40, suggesting potential long-term cognitive impacts.

23 Jun 2024

Premenopausal oophorectomy reduces white matter integrity in the brain later in life

Women who have their ovaries removed before menopause, particularly before the age of 40, have reduced white matter integrity in multiple regions of the brain later in life.

20 Jun 2024

Largest study of BRCA1 and BRCA2 carriers refines cancer risk estimates in Asian population

A team of clinician-scientists and scientists from the University of Nottingham (Malaysia campus), National Cancer Centre Singapore (NCCS), Cancer Research Malaysia, Nanyang Technological University, Singapore (NTU Singapore), University of Malaya, University of Cambridge, A*STAR's Genome Institute of Singapore (GIS) and other institutions, have conducted the largest study done to date of BRCA1 and BRCA2 (BReast CAncer Gene 1 and 2) carriers in an Asian population and refined breast and ovarian cancer risk estimates for this population.

26 Apr 2024

New approach needed to better prepare and support women during menopause transition, experts say

A new approach to menopause that better prepares and supports women during midlife is needed – going beyond medical treatments, to empower women using high-quality information on symptoms and treatments, empathic clinical care and workplace adjustments as required, says a new four paper Series published in The Lancet.

6 Mar 2024

Early onset of menstruation and menopause associated with increased risk of COPD

The association between female reproductive factors and the risk of developing COPD.

14 Feb 2024

Study identifies hormonal and reproductive factors for rheumatoid arthritis in women

Early menopause - before the age of 45 - taking hormone replacement therapy (HRT), and having 4 or more children are among several hormonal and reproductive factors linked to a heightened risk of rheumatoid arthritis in women, finds a large long term study published in the open access journal RMD Open.

9 Jan 2024

Can PTSD deteriorate women's cardiovascular and neurological health?

Whether posttraumatic stress disorder (PTSD) symptoms in civilian midlife women negatively affected their cardiovascular and neurocognitive health.

6 Nov 2023

Study reveals potential negative long-term effects of premenopausal bilateral oophorectomy

Increasing concerns regarding potentially harmful long-term effects of premenopausal bilateral oophorectomy (PBO) have caused a decline in the number of women choosing to proactively remove both ovaries as a precaution to protect against ovarian cancer.

13 Sep 2023

NSAID use linked to higher risk of blood clots in women of reproductive age, association stronger in women on high-risk hormonal contraception

A new paper published in The BMJ explores the effect of these drugs used concomitantly on the risk of venous thromboembolism (VTE).

8 Sep 2023

Gynecologic procedures may be associated with increased risk of cardiovascular disease

A new study showed that hysterectomy alone, hysterectomy with oophorectomy, and tubal ligation were all associated with an increased risk of cardiovascular disease (CVD).

11 May 2023

Endometriosis linked to increased risk of cardiovascular disease in women

In a recent study published in the journal Maturitas, researchers conducted a systematic review and meta-analysis to compare the risk of cardiovascular events in women with and without endometriosis.

12 Apr 2023

Age at menopause and hormone therapy use associated with increased risk of Alzheimer’s disease

Women are more likely than men to develop Alzheimer's disease (AD), with women making up two-thirds of the population living with AD.

3 Apr 2023

Women with a BRCA1 or BRCA2 pathogenic variant have high risk of cancer after age 50

Although genetic mutations in BRCA1 or BRCA2 are associated with a younger onset of breast and ovarian cancer, women with these genetic mutations continue to face a high risk of cancer incidence after age 50, even if they have not been previously diagnosed with cancer.

24 Feb 2023

Individuals who detransition avoid medical help, study finds

Medical education, research and clinical guidelines are all available to support the initiation of gender-affirming care for transgender people, but a York University-led qualitative study has found these resources are sparse when patients discontinue or reverse gender-affirming medical or surgical interventions - referred to as detransition.

26 Jul 2022

Women a history of endometriosis may have greater stroke risk

A large, prospective study found that women with endometriosis may have a higher risk of stroke compared to women without the chronic inflammatory condition, according to new research published today in Stroke, the peer-reviewed flagship journal of the American Stroke Association, a division of the American Heart Association.

21 Jul 2022