Signaling Pathway News and Research

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New studies reveal hidden control hub for MYC-driven cancers

In a rare pair of papers published back-to-back in the journal Genes & Development, research teams led by senior author Anindya Bagchi, PhD, associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys Medical Discovery Institute, establish a unified framework that governs one of cancer's most powerful master regulators.

19 Aug 2026

First high-resolution cell-by-cell map tracks tomato root and fungal partnership

Scientists at VIB and Ghent University have produced the first high-resolution, cell-by-cell map of how tomato roots respond to colonization by arbuscular mycorrhizal fungi.

18 Aug 2026

Immune signaling pathway protects newborn heart cells from injury

Researchers at the University Hospital of Bonn (UKB) and the University of Bonn have identified a previously unknown signaling pathway in the immune system that helps newborn heart cells survive and regenerate after injury.

17 Aug 2026

Coral-inspired scaffold enhances bone repair by reprogramming immune cells

SONFH is one of the leading causes of non-traumatic osteonecrosis. Reported in up to 9%–40% of patients receiving prolonged or high-dose glucocorticoid therapy, the condition progressively weakens the femoral head and can eventually lead to joint collapse, making effective bone repair a major clinical challenge.

13 Aug 2026

Genetic tool turns soft cancer cells into immune targets

Researchers at the USC Viterbi School of Engineering and Keck School of Medicine of USC have engineered a remarkable genetic tool that addresses one of the most persistent obstacles in cancer immunotherapy: the physical softness of tumors.

11 Aug 2026

New study identifies key pathway for delivering antisense cancer drugs

Antisense oligonucleotides (ASOs) have been proposed as a therapeutic approach to shut down the production of faulty proteins in a wide variety of diseases, including cancer.

11 Aug 2026

Natural hormone activates brain-to-liver signaling pathway to suppress liver inflammation

Researchers at McMaster University have discovered that a naturally occurring hormone best known for suppressing appetite and promoting weight loss also helps protect the liver from inflammation through a previously unknown signalling pathway, opening new possibilities for treating advanced fatty liver disease.

10 Aug 2026

Newly discovered protein pathway limits spinal cord injury damage

Spinal cord injury begins with immediate mechanical damage, but much of the lasting neurological loss develops during the secondary phase, when inflammation, oxidative stress and disrupted metabolism continue to injure surviving tissue.

10 Aug 2026

IL-6 receptor blockers show promise for preventing MOGAD relapses

An international study led by Mayo Clinic researchers has identified interleukin-6 (IL-6) receptor blockers as a promising option for preventing relapses in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). MOGAD is a rare autoimmune neurological disorder that can cause vision loss, paralysis and other serious neurological complications.

6 Aug 2026

Study shows how solid food shapes immune system development

In a mouse model, LMU researchers have discovered a signaling pathway through which diet influences the development of the immune system.

4 Aug 2026

RNA-based therapeutic strategy targets brain pathway behind cancer-associated cachexia

A new path has opened toward stopping cancer-associated cachexia, a devastating complication that gradually wastes patients away.

2 Aug 2026

Jet lag may disrupt athletes' gut microbiome and slow recovery

The interplay between jet lag and gut microbiome affects athlete performance. Strategies to manage these disruptions are crucial but not yet fully established.

30 Jul 2026

Overactive brain immune response linked to rare, severe genetic epilepsy

An overactive immune response in the brain may play a role in Dravet Syndrome, a rare and severe genetic epilepsy that typically begins in infancy, according to Weill Cornell Medicine researchers.

29 Jul 2026

Cell junction proteins regulate stem cell signaling and tissue homeostasis

In many animal tissues, stem cells continually divide to create new cells that replace old or damaged ones. However, this capacity requires strict regulation, as uncontrolled stem cell proliferation can disrupt tissue homeostasis and contribute to tumorigenesis.

28 Jul 2026

Iowa State study identifies potential new target for leukemia treatment

In leukemia's most aggressive forms, the blood cell factories in our bone marrow falter. Instead of dividing and multiplying at their usual prolific pace, generating hundreds of billions of new cells daily, some precursor cells stall out at an immature stage.

24 Jul 2026

Genetic background shapes cancer development despite identical risk factors

Why do cancers develop differently in different people-even when they are exposed to the same risk factors? An international research group, including the German Cancer Research Center (DKFZ), has now demonstrated in mice that an organism's genetic makeup significantly influences the course of cancer development.

22 Jul 2026

Dysregulation of immune regulator NF-κB drives major human diseases

NF‑κB controls genes involved in inflammation, immunity, cell survival, and proliferation. Triggered by cytokines (TNF‑α, IL‑1β), microbial products, or cellular stress, it translocates to the nucleus and induces pro‑inflammatory mediators.

13 Jul 2026

Stem cell study uncovers molecular pathway for enamel regeneration

Tooth enamel is the hardest substance in the human body, yet once damaged, it cannot regenerate naturally.

9 Jul 2026

Setmelanotide shows promise for hypothalamic obesity after brain tumors

A new therapy helps achieve a healthier BMI in people whose weight has become dysregulated following treatment for a brain tumor, a clinical trial has found.

8 Jul 2026

Bio-Techne launches expanded R&D Systems AI-Engineered Designer Protein Portfolio

Bio-Techne Corporation, a global provider of life science tools, reagents, and diagnostic products, today announced the launch of new additions to its R&D Systems™ AI-Engineered Designer Protein portfolio, designed to improve reproducibility and performance across advanced cell culture and cell therapy development workflows.

From Bio-Techne 8 Jul 2026