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Brain organoids reveal new clues for childhood epilepsy treatments

Tiny, year-old human brain organoids that mimic the brain of a newborn are providing new clues to potential treatments for a leading genetic cause of childhood epilepsy that typically manifests as the brain matures shortly after birth.

23 Sep 2026

Regular exercisers show distinct metabolic and immune signatures in blood

Researchers compared blood samples from 40 regular exercisers and 46 sedentary adults and found differences in metabolites, blood chemistry, and immune cell gene activity. The patterns suggested greater fatty acid use and altered immune signaling among exercisers, but the study could not establish that exercise caused these differences.

21 Sep 2026

Transplanted human cortical organoids filled most of a mouse cortex. Then they began to connect

Researchers created xenocortical mice by transplanting human cortical organoids into animals genetically depleted of much of their native cortex, allowing the human tissue to occupy most of the available cortical space and form anatomical connections throughout the host nervous system. The grafts developed diverse cortical cell types, including L5-ET and VEN-like neurons, generated organized neural activity, and produced measurable cellular and behavioral responses to hypoxic injury.

18 Sep 2026

Giant-nucleus cells form the foundation of early-stage cancer

Iron is an essential micronutrient, but excess iron can damage cells and increase cancer risk. While many cells die from iron-induced oxidative stress, a subset survives and may become cancerous.

11 Sep 2026

Refined starch activates immune pathways after low-carb weight loss

After substantial weight loss on a very-low-carbohydrate diet, participants who switched to a diet rich in refined starch showed greater activation of circulating immune and metabolic pathways than those who continued the low-carbohydrate diet or consumed a high-carbohydrate diet rich in added sugar. Mouse experiments suggested that activation of the complement immune pathway may help explain the inflammatory response associated with starch intake.

10 Sep 2026

New brain atlas reveals insights into Huntington's, addiction, and other disorders

A region of the brain called the striatum is critical for many cognitive and motor functions, including decision-making, control of movement, habit formation, and processing of reward.

1 Sep 2026

AI tools map tumor architecture to predict treatment response

Spatial transcriptomics is a powerful tool to create a detailed map of not just how genes are expressed in a piece of tissue, but also where genetic activity takes place in different cells and locations within the tissue.

31 Aug 2026

Newly identified cells protect lung tumors from immune attacks

Researchers at Columbia University have discovered a new type of cell that protects lung cancers from attacks by the immune system.

27 Aug 2026

New review highlights spatial technologies in advanced brain mapping

Understanding how molecular changes shape brain function and disease requires more than measuring genes in bulk tissue.

21 Aug 2026

UVA researchers find how postoperative delirium may set the stage for dementia

UVA Health researchers have discovered how a form of delirium that often strikes older patients after surgery may set the stage for dementia – and identified a drug that could reverse the underlying brain changes.

18 Aug 2026

First high-resolution cell-by-cell map tracks tomato root and fungal partnership

Scientists at VIB and Ghent University have produced the first high-resolution, cell-by-cell map of how tomato roots respond to colonization by arbuscular mycorrhizal fungi.

18 Aug 2026

AI-based methods help uncover hidden roots of tumor metastasis

A cancerous tumor is not a single enemy. It is made up of many different cell populations that can behave in very different ways.

12 Aug 2026

Aging clock analysis identifies key genes in opioid dependence

A new research paper was published in Volume 18 of Aging on July 27, 2026, titled "Transcriptomic aging clock analysis identifies key genes in opioid dependence."

12 Aug 2026

Molecular mapping reveals hidden cellular programs in heart transplant rejection

A new study that explores gene expression during heart transplant rejection marks a step forward for precision medicine approaches to treat organ rejection.

12 Aug 2026

Natural hormone activates brain-to-liver signaling pathway to suppress liver inflammation

Researchers at McMaster University have discovered that a naturally occurring hormone best known for suppressing appetite and promoting weight loss also helps protect the liver from inflammation through a previously unknown signalling pathway, opening new possibilities for treating advanced fatty liver disease.

10 Aug 2026

Spatial transcriptomics study elucidates cellular dynamics during heart transplant rejection

A new study that explores gene expression during heart transplant rejection marks a step forward for precision medicine approaches to treat organ rejection.

10 Aug 2026

New review advances understanding of biological mechanisms driving Ménière's disease

A comprehensive new review is bringing together the latest advances in Ménière's disease, offering a clearer picture of the biological mechanisms that may drive this complex inner ear disorder while highlighting new directions for diagnosis, disease modeling, and treatment.

6 Aug 2026

Transcriptomics News and Research

Brain organoids reveal new clues for childhood epilepsy treatments

Regular exercisers show distinct metabolic and immune signatures in blood

Transplanted human cortical organoids filled most of a mouse cortex. Then they began to connect

Giant-nucleus cells form the foundation of early-stage cancer

Refined starch activates immune pathways after low-carb weight loss

New brain atlas reveals insights into Huntington's, addiction, and other disorders

AI tools map tumor architecture to predict treatment response

Newly identified cells protect lung tumors from immune attacks

New review highlights spatial technologies in advanced brain mapping

UVA researchers find how postoperative delirium may set the stage for dementia

First high-resolution cell-by-cell map tracks tomato root and fungal partnership

AI-based methods help uncover hidden roots of tumor metastasis

Aging clock analysis identifies key genes in opioid dependence

Molecular mapping reveals hidden cellular programs in heart transplant rejection

Natural hormone activates brain-to-liver signaling pathway to suppress liver inflammation

Spatial transcriptomics study elucidates cellular dynamics during heart transplant rejection

New review advances understanding of biological mechanisms driving Ménière's disease

Multi-omics research uncovers new therapeutic targets for Fabry disease

Nerve-tumor interactions emerge as a transformative frontier in oncology

Texas A&M study links polyethylene microplastics to fatty liver disease

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