Uric Acid News and Research

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Study identifies a reductive uric acid degradation pathway in anaerobic bacteria

Uric acid builds up in the blood when the body cannot excrete it efficiently, leading to painful gout attacks, kidney stones, and other complications.

8 Sep 2025

Eating over 60g of almonds a day may protect DNA and cut oxidative damage

A meta-analysis of eight clinical trials found that almond supplementation, especially at doses above 60 g/day, significantly reduced oxidative DNA and lipid damage and improved antioxidant enzyme activity in adults. The benefits varied by biomarker and were influenced by dose, preparation, and participant characteristics.

14 Aug 2025

Understanding the biomarkers and mechanisms associated with anti-NMDAR encephalitis

Encephalitis is a potentially life-threatening condition that involves inflammation of the brain. While some cases of encephalitis are caused by a bacterial or viral infection, other cases of 'autoimmune' encephalitis result when the body's own immune system attacks the brain.

8 Aug 2025

Intermittent energy restriction shows strong benefits for people with obesity and type 2 diabetes

Intermittent energy restriction, time-restricted eating and continuous energy restriction can all improve blood sugar levels and body weight in people with obesity and type 2 diabetes, according to a study being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

13 Jul 2025

Back-to-basics, 'not fad' diets beat heart disease and diabetes

This review examines dietary interventions that can improve cardiometabolic health, highlighting the role of whole foods in reducing heart disease and diabetes.

4 Jun 2025

Eating kombu daily enhances gut health and heart markers in men

A 12-week randomized trial found that daily intake of boiled kombu (Laminaria japonica) powder reduced body fat and raised adiponectin in Japanese men, while improving blood pressure and gut microbiota in both sexes. No significant effects were seen in women for body fat reduction or adiponectin.

20 May 2025

EMA designates allopurinol as first orphan drug for the treatment of Marfan syndrome

The European Medicines Agency (EMA) has designated allopurinol as the first orphan drug for the treatment of Marfan syndrome, a rare connective tissue disease which as no cure to date.

19 May 2025

Lipid accumulation levels reveal hidden osteoporosis risk

Researchers investigate the use of lipid accumulation products as a predictor of osteoporosis.

14 May 2025

Low testosterone linked to higher kidney stone risk in men, study finds

A large cross-sectional study in South Korea found that men with low testosterone levels (below 3.33 ng/mL) were significantly more likely to have kidney stones. This association held even after adjusting for age and metabolic risk factors, suggesting testosterone may play a protective role.

6 May 2025

High fructose diets impair brain function and appetite control, study shows

Review highlights how excessive fructose intake disrupts brain energy balance, appetite regulation, and cognitive function. Processed sources, such as sugary drinks, may overwhelm metabolic pathways and induce neuroinflammation, particularly during adolescence.

30 Apr 2025

N-acetylcysteine protects against acyclovir-induced nephrotoxicity

Oxidative stress could be a key process in acyclovir (ACV)-induced nephrotoxicity. N-acetylcysteine (NAC) is a water-soluble antioxidant with anti-inflammatory activity.

18 Apr 2025

Study shows potential of uric acid as add-on therapy for stroke

In a preclinical study, rodents treated with uric acid showed improved long-term outcomes after acute ischemic stroke. The findings suggest that the treatment may work as an add-on therapy to standard stroke treatments in humans.

17 Mar 2025

Can the carnivore diet trigger kidney stones? Case study raises red flags

A case study in The American Journal of Clinical Nutrition examines how one patient’s switch to a carnivore diet increased kidney stone risk by raising calcium, uric acid, and oxalate levels while reducing protective citrate.

19 Feb 2025

Could a common sugar in processed foods be fueling childhood liver disease?

Researchers found that high fructose intake, especially from processed foods, is linked to metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity, with potential misreporting of sugary food sources.

12 Feb 2025

Elevated uric acid levels may contribute to severe malaria outcomes in children

Indiana University School of Medicine researchers and their collaborators in Uganda at the Makerere University School of Medicine have uncovered a significant connection between elevated uric acid levels and life-threatening outcomes in children with severe malaria.

27 Jan 2025