Genetic Engineering News and Research

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Study brings precision medicine closer to reality for diffuse large B cell lymphoma

DNA mutations are essential to the rapid development of an array of antibody-producing immune cells called B cells that collectively can recognize a vast number of specific targets.

25 May 2022

Antibiotic rifampicin attenuates C9orf72-linked dementia in genetically modified mice

What did Stephen Hawking and Mao Zedong have in common? They both suffered from Amyotrophic Lateral Sclerosis (ALS), a cure for which remains elusive. Scientists from Osaka Metropolitan University took an important step toward prevention of ALS and another brain disorder called Frontotemporal dementia (FTD) with their research on the effects of the antibiotic rifampicin on genetically modified mice.

23 May 2022

Study demonstrates how the transcription factor C/EBPβ can positively influence fat storage

The chronic nutritional and metabolic disease of obesity is characterized by an excessive increase in body fat and its accumulation in tissues.

20 May 2022

Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

In a recent study posted to the bioRxiv* pre-print server, researchers from Belgium evaluated the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral drugs in a severe combined immunodeficient (SCID) mouse model.

18 May 2022

SARS-CoV-2 infection could increase the risk of brain degeneration seen in Parkinson's disease

Brain fog, headaches, insomnia are some of the neurological symptoms doctors have observed in COVID-19 patients.

18 May 2022

Study identifies cancer biomarkers based on a type of genetic modification

Biomarkers are often used during the management of cancer to guide treatment decisions and predict patient outcomes. However, it is often difficult to identify appropriate biomarkers that can be consistently reproduced and are easily analyzed with limited patient specimens.

18 May 2022

First patient dosed in Phase 1 clinical trial evaluating the safety of CF33-hNIS against solid tumors

Imugene Limited, a clinical stage immuno-oncology company, and City of Hope, one of the largest cancer research and treatment organizations in the United States, today announced that the first patient was dosed in a Phase 1 clinical trial evaluating the safety of novel cancer-killing virus CF33-hNIS VAXINIA when used in people with advanced solid tumors.

18 May 2022

Sonic hedgehog plays key role in the repair strategy of large bone injuries

A USC Stem Cell study in NPJ Regenerative Medicine presents intriguing evidence that large bone injuries might trigger a repair strategy in adults that recapitulates elements of skeletal formation in utero. Key to this repair strategy is a gene with a fittingly heroic name: Sonic hedgehog.

17 May 2022

Exercise increases levels of brain-derived neurotrophic factor which bolsters dopamine release

Exercise increases levels of a chemical involved in brain cell growth, which bolsters the release of the "feel good" hormone dopamine, a new study shows. Dopamine is known to play a key role in movement, motivation, and learning.

16 May 2022

Researchers use bacteriophages to treat antibiotic-resistant mycobacterial lung infection

For the first time, researchers have successfully used bacteriophages – viruses that kill bacteria – to treat an antibiotic-resistant mycobacterial lung infection, clearing the way for a young National Jewish Health patient with cystic fibrosis to receive a life-saving lung transplant.

13 May 2022

Researchers pursue a new way to use milk for delivering cancer-fighters to the brain

In health care, perhaps no word sends a more chilling message than "cancer." Brain tumors, for example, prove especially resistant to current treatments. Only 5% of patients with that condition survive more than three years and the median survival time is 10 to 14 months.

12 May 2022

Rural California hatches plan for engineered mosquitoes to battle stealthy predator

Bryan Ruiz moved his family into a newly built home in this Central Valley farming center seven months ago and almost immediately found they were under assault.

10 May 2022

New insights into the cellular and molecular mechanisms of absence seizures

Bochum researchers have gained new insights into the cellular and molecular mechanisms of absence seizures and potential therapy options.

4 May 2022

Scientists discover a potential new method of active immunization to prevent Alzheimer's disease

During experiments in animal models, researchers at the University of Kansas have discovered a possible new approach to immunization against Alzheimer's disease (AD).

4 May 2022

Using silk proteins for tendon repair

Just mentioning a ruptured Achilles tendon would make anyone wince. Tendon injuries are well known for their lengthy, difficult and often incomplete healing processes.

3 May 2022

New technology to make temporary genetic modifications tested in mosquitoes

Texas A&M AgriLife Research scientists have tested a technology to make temporary genetic modifications in mosquitoes. The modifications self-delete over time.

3 May 2022

Study reveals new approach for engineering stable articular cartilage

A new study assesses the effect of the gremlin-1 (GREM1) protein on the in vitro and in vivo stability of bone marrow stem cell (BMSC)-derived cartilage engineered within scaffolds.

29 Apr 2022

Dual release microparticle system promotes cranial bone defect healing

A new dual delivery system designed to sequentially release BMP2 and IGF1 in microparticles in an injectable hydrogel successfully healed an 8-mm cranial defect in rats.

21 Apr 2022

Scientists identify innovative treatment approach for arterial thromboses

Scientists have shown in an animal model that the CXCL12 messenger could be suitable as a target structure for the treatment of blood-clotting disorders.

21 Apr 2022

Researchers identify brain areas that control the ability to perform complex, sequential movements

In a novel set of experiments with mice trained to do a sequence of movements and "change course" at the spur of the moment, Johns Hopkins scientists report they have identified areas of the animals' brains that interact to control the ability to perform complex, sequential movements, as well as to help the mice rebound when their movements are interrupted without warning.

21 Apr 2022

Genetic Engineering News and Research

Study brings precision medicine closer to reality for diffuse large B cell lymphoma

Antibiotic rifampicin attenuates C9orf72-linked dementia in genetically modified mice

Study demonstrates how the transcription factor C/EBPβ can positively influence fat storage

Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

SARS-CoV-2 infection could increase the risk of brain degeneration seen in Parkinson's disease

Study identifies cancer biomarkers based on a type of genetic modification

First patient dosed in Phase 1 clinical trial evaluating the safety of CF33-hNIS against solid tumors

Sonic hedgehog plays key role in the repair strategy of large bone injuries

Exercise increases levels of brain-derived neurotrophic factor which bolsters dopamine release

Researchers use bacteriophages to treat antibiotic-resistant mycobacterial lung infection

Researchers pursue a new way to use milk for delivering cancer-fighters to the brain

Rural California hatches plan for engineered mosquitoes to battle stealthy predator

New insights into the cellular and molecular mechanisms of absence seizures

Scientists discover a potential new method of active immunization to prevent Alzheimer's disease

Using silk proteins for tendon repair

New technology to make temporary genetic modifications tested in mosquitoes

Study reveals new approach for engineering stable articular cartilage

Dual release microparticle system promotes cranial bone defect healing

Scientists identify innovative treatment approach for arterial thromboses

Researchers identify brain areas that control the ability to perform complex, sequential movements

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