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Exploring the link between maternal care and attachment in mouse pups

Children can sometimes develop health, behavioral, and attachment issues that persist when their needs are not met by their caregiver.

27 Oct 2025

Study finds evidence for repurposing thiostrepton as an anti-rhabdomyosarcoma drug

Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.

27 Oct 2025

Mitochondria and lysosomes work together to control regulatory T cell activation

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

24 Oct 2025

GemPharmatech collaborates with MSK Cancer Center to accelerate discovery of therapeutic antibodies

GemPharmatech, a global leader in preclinical research solutions and genetically-engineered mouse models, today announced a collaboration with Memorial Sloan Kettering Cancer Center (MSK) to accelerate the discovery of new therapeutic antibodies.

23 Oct 2025

Psoriasis-linked gene mutation may also play a surprising role in gut health

A mutation previously linked to skin disorders like psoriasis may also play a surprising role in gut health, according to new research published by scientists at VIB-UGent and colleagues from UGent, the University of Barcelona, and University College London.

23 Oct 2025

Nuclear binding protein identified as key contributor to trisomy 21-related CHDs

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs).

22 Oct 2025

HMGN1 gene linked to heart problems in people with Down syndrome

Nearly half of all babies born with Down syndrome face congenital heart defects, often involving serious malformations that require surgery in the first months of life.

22 Oct 2025

New discovery could someday help prevent breast cancer recurrence

Know someone who's been diagnosed with breast cancer? There's a good chance that person has received hormone therapy.

21 Oct 2025

Researchers discover how a brain circuit allows eating despite anxiety

How do mammals manage to eat in situations that cause anxiety, step into exposed spaces, or slow down when anxiety drives them to keep moving? A new study pinpoints a leptin-sensitive circuit in the lateral hypothalamus that helps to overcome anxiety to perform essential behaviors such as exploring, feeding, and limiting maladaptive hyperactivity.

21 Oct 2025

Study reveals how a microglial mutation increases risk for Alzheimer's disease

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer's Disease by Impairing Microglial Function."

17 Oct 2025

Runx1 overexpression triggers early intervertebral disc degeneration

A new research paper was published in Volume 17, Issue 9 of Aging-US on September 8, 2025, titled, "Runx1 overexpression induces early onset of intervertebral disc degeneration."

17 Oct 2025

Blocking key protein restores healthy lung function and reduces fibrosis in mice

Pulmonary fibrosis is a deadly disease in which the lungs become thickened and scarred, gradually losing their ability to deliver oxygen to the body.

16 Oct 2025

Fatty acids found to be a primary driver of triple-negative tumor growth

A team from Huntsman Cancer Institute at the University of Utah (the U) has found that triple-negative breast cancer is fueled by lipids and that these fatty acids are a key feature of obesity that promote tumor growth.

16 Oct 2025

Low-dose steroids show promise for treating severe kidney inflammation

Will it be possible to treat severe kidney inflammation with fewer drugs in the future? A new study by the University Hospital Bonn (UKB), the University of Bonn, and the University of Hamburg gives cause for hope.

15 Oct 2025

Discovery explains why women face higher risk of Alzheimer’s and multiple sclerosis

New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain, offering insight into why women are disproportionately affected by conditions such as Alzheimer's disease and multiple sclerosis as well as offering a potential target for intervention.

15 Oct 2025

Estradiol and estriol may protect nerve function in multiple sclerosis

About 100,000 of the estimated million people in the United States with multiple sclerosis (MS) have a progressive form of the disease, with symptoms that worsen continuously or after periods of remission.

14 Oct 2025

New approach protects the brain from radiation-induced cognitive decline

While tremendous relief comes from successfully battling cancer, survivors can also experience cognitive impairments caused by the disease and its treatment.

14 Oct 2025

Scientists revive diabetic beta cells, revealing a new path to restore insulin function

Researchers demonstrated that pancreatic β cells from type 2 diabetes donors can partially regain glucose responsiveness when cultured outside the diabetic environment. This recovery, driven by specific gene expression changes, identifies JAK inhibitors as potential therapeutic candidates to restore β-cell function.

14 Oct 2025

Natural nasal microbes offer broad-spectrum antiviral protection

Respiratory viral diseases pose severe threats to animal health and global food security, especially in intensive pig farming systems.

10 Oct 2025

Study reveals how DKK3 triggers smooth muscle cell transformation in aortic aneurysm

Abdominal aortic aneurysm (AAA) is a life-threatening vascular disorder that primarily affects elderly males.

10 Oct 2025

Mouse Model News and Research

Exploring the link between maternal care and attachment in mouse pups

Study finds evidence for repurposing thiostrepton as an anti-rhabdomyosarcoma drug

Mitochondria and lysosomes work together to control regulatory T cell activation

GemPharmatech collaborates with MSK Cancer Center to accelerate discovery of therapeutic antibodies

Psoriasis-linked gene mutation may also play a surprising role in gut health

Nuclear binding protein identified as key contributor to trisomy 21-related CHDs

HMGN1 gene linked to heart problems in people with Down syndrome

New discovery could someday help prevent breast cancer recurrence

Researchers discover how a brain circuit allows eating despite anxiety

Study reveals how a microglial mutation increases risk for Alzheimer's disease

Runx1 overexpression triggers early intervertebral disc degeneration

Blocking key protein restores healthy lung function and reduces fibrosis in mice

Fatty acids found to be a primary driver of triple-negative tumor growth

Low-dose steroids show promise for treating severe kidney inflammation

Discovery explains why women face higher risk of Alzheimer’s and multiple sclerosis

Estradiol and estriol may protect nerve function in multiple sclerosis

New approach protects the brain from radiation-induced cognitive decline

Scientists revive diabetic beta cells, revealing a new path to restore insulin function

Natural nasal microbes offer broad-spectrum antiviral protection

Study reveals how DKK3 triggers smooth muscle cell transformation in aortic aneurysm

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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