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Blocking immune brake protein boosts defense against Aspergillus fumigatus

People are exposed to millions of fungal spores every day, even potentially harmful ones like those from Aspergillus fumigatus.

11 Sep 2025

CRISPR-based therapeutic approach designed to treat fatal pediatric disease

Multisystemic smooth muscle dysfunction syndrome (MSMDS) is a rare condition associated with stroke, aortic dissection (tearing) and death in childhood.

11 Sep 2025

Infection or stressful events during pregnancy may increase anxiety risk in offspring

Increased risk for anxiety may begin before birth, shaped by infection or stressful events during pregnancy, according to a new preclinical study from researchers at Weill Cornell Medicine.

11 Sep 2025

Experts review the evidence on coenzyme Q10 and cognitive decline

Researchers reviewed evidence on coenzyme Q10 (CoQ10) and cognition, finding strong biological support and positive results in animal models but mixed outcomes in human trials. Larger, high-quality studies are needed to clarify whether CoQ10 can protect against cognitive decline and neurodegenerative diseases.

9 Sep 2025

Berberine improves cognitive function in diabetic encephalopathy mice

A recent study published in Engineering has shed new light on the potential therapeutic effects of berberine (BBR), a natural compound derived from traditional Chinese medicine, in treating diabetic encephalopathy (DE).

9 Sep 2025

Scientists identify key protein driving severe flu in older people

Scientists have discovered why older people are more likely to suffer severely from the flu, and can now use their findings to address this risk.

8 Sep 2025

Study identifies a reductive uric acid degradation pathway in anaerobic bacteria

Uric acid builds up in the blood when the body cannot excrete it efficiently, leading to painful gout attacks, kidney stones, and other complications.

8 Sep 2025

New 3D eye model reveals causes of steroid-related glaucoma

The eye, like most organs, has an intricate plumbing system. Pressure builds when drainage is impaired, and this condition – glaucoma – can cause irreversible vision loss.

4 Sep 2025

Targeting complement with an inhibitor may prevent preterm birth and protect the baby’s brain

A research team at the Medical University of South Carolina reports in Cells that the complement system, part of the body's natural immune defenses, is a key driver of inflammatory responses that contribute to fetal brain inflammation and preterm birth, the latter of which is the leading cause of complications and death in newborns.

4 Sep 2025

Penn State researchers reveal new function of antibody-producing cells

The body has an intricate system to defend against infections where each type of immune cell plays a distinct role. Now, a study led by researchers from the Penn State College of Medicine has uncovered a new function of the immune cells that are known for making antibodies.

3 Sep 2025

New mouse models reveal mechanisms of RP59 retinal degeneration

Retinitis pigmentosa retinal degeneration is caused by a family of hereditary mutations in nearly 100 genes that slowly lead to blindness over years or decades.

29 Aug 2025

Alzheimer’s research uncovers a new therapeutic pathway for the memory-robbing malady

The gut contains the largest collection of immune cells in the body. New research at the Buck Institute shows that some of those immune cells travel along the brain/gut axis in a mouse model of Alzheimer's disease (AD) providing a potential new therapeutic pathway for the memory-robbing malady.

29 Aug 2025

Cellular purging process may help injured cells revert to stem cell-like state more rapidly

Now, a new study in mice led by researchers at Washington University School of Medicine in St. Louis and the Baylor College of Medicine reveals a previously unknown cellular purging process that may help injured cells revert to a stem cell-like state more rapidly.

29 Aug 2025

Stress in mothers causes eczema in newborn mice through immune cell changes

Maternal prenatal stress in mice disrupts fetal mast cell programming, triggering eczema-like skin inflammation and heightened sensitivity after birth. The findings reveal how corticosterone-driven immune and neuronal changes in utero may set the stage for pediatric eczema risk.

28 Aug 2025

New NIH-funded project aims to turn rare HIV cures into broadly applicable immunotherapy

Nearly 20 years ago, a man named Timothy Ray Brown who was living with HIV and cancer, underwent two courses of stem cell transplantation to treat his acute myeloid leukemia.

28 Aug 2025

Routine eye exams may help detect Alzheimer’s years before symptoms appear

Within the next few years, doctors may be able to spot signs of Alzheimer's disease and other dementias using routine eye exams well before symptoms appear, a new study suggests.

27 Aug 2025

Regenerative strategy offers hope for women with pelvic organ prolapse

Pelvic organ prolapse (POP) is a disorder that primarily affects older women who have experienced multiple vaginal childbirths.

27 Aug 2025

New research reveals why blood clotting malfunctions in inflammatory bowel disease

Inflammatory bowel disease, in which the immune system attacks the gut, is a painful chronic condition that affects three million Americans. Rates of IBD are rising, and there's currently no cure. IBD can also be deadly: up to 8% of people with the disease develop blood clots, which can lead to heart attack and stroke.

25 Aug 2025

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality.

22 Aug 2025

New formulation of chemotherapy drug opens doors to advanced cancer treatment options

University of Arizona researchers devised a new method to deliver cancer chemotherapy drugs to pancreatic and breast cancer tumors more effectively and with less damage to healthy tissues than standard forms of chemotherapy.

21 Aug 2025

Mouse Model News and Research

Blocking immune brake protein boosts defense against Aspergillus fumigatus

CRISPR-based therapeutic approach designed to treat fatal pediatric disease

Infection or stressful events during pregnancy may increase anxiety risk in offspring

Experts review the evidence on coenzyme Q10 and cognitive decline

Berberine improves cognitive function in diabetic encephalopathy mice

Scientists identify key protein driving severe flu in older people

Study identifies a reductive uric acid degradation pathway in anaerobic bacteria

New 3D eye model reveals causes of steroid-related glaucoma

Targeting complement with an inhibitor may prevent preterm birth and protect the baby’s brain

Penn State researchers reveal new function of antibody-producing cells

New mouse models reveal mechanisms of RP59 retinal degeneration

Alzheimer’s research uncovers a new therapeutic pathway for the memory-robbing malady

Cellular purging process may help injured cells revert to stem cell-like state more rapidly

Stress in mothers causes eczema in newborn mice through immune cell changes

New NIH-funded project aims to turn rare HIV cures into broadly applicable immunotherapy

Routine eye exams may help detect Alzheimer’s years before symptoms appear

Regenerative strategy offers hope for women with pelvic organ prolapse

New research reveals why blood clotting malfunctions in inflammatory bowel disease

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

New formulation of chemotherapy drug opens doors to advanced cancer treatment options

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