Genetic News and Research

RSS

Children should drink milk to help prevent osteoporosis

For generations children have been urged to drink milk for strong. healthy bones and teeth. New research from Southampton, UK, announced today (26 May) is taking this a step further, showing the link between drinking mild and reducing the risk of osteoporosis in later life.

26 May 2008

Intracellular antibody mops up mutant protein in Huntington's disease model

Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. Emory University researchers engineered a virus to make an intracellular antibody or "intrabody" against huntingtin, the protein whose mutant forms poison the brain cells of people with Huntington's.

26 May 2008

Why do some heavy drinkers develop mouth and throat cancers while others do not?

A study by researchers in Europe has revealed why some heavy drinkers develop mouth and throat cancers while others do not and also why some people get drunk quickly.

26 May 2008

Link between HPV and cervical cancer

Scientists in the United States have carried out a review of research to determine the link between persistent HPV (human papillomavirus) infection and cervical cancer.

25 May 2008

The emerging role of infection in Alzheimer’s

A number of chronic diseases are in fact caused by one or more infectious agents. For example, stomach ulcers are caused by Helicobacter pylori, chronic lung disease in newborns and chronic asthma in adults are both caused by Mycoplasmas and Chlamydia pneumonia, while some other pathogens have been associated with atherosclerosis. The realization that pathogens can produce slowly progressive chronic diseases has opened new lines of research into Alzheimer's disease.

25 May 2008

Scientists back the use of maize as an efficient 'factory' for protein-based pharmaceutical products

Scientists from the Universidad de Lleida (University of Lleida) have published a study confirming that maize seeds are an effective and sure platform within molecular agriculture to alleviate diseases. Over the next few years AIDS could be one of the first diseases to benefit from these results, although regulations for this technology are being developed at the same time as research is being undertaken.

25 May 2008

Research shows protecting p53 from degradation also defends metastasis-promoter

Efforts to protect the tumor-suppressor p53 could just as easily shelter a mutant version of the protein, causing cancer cells to thrive and spread rather than die, according to research by scientists at The University of Texas M. D. Anderson Cancer Center reported in the current issue of the journal Genes and Development.

22 May 2008

Simple blood test could indicate higher risk for coronary events in women after post-menopausal hormone therapies

A research study has found that a simple blood test may indicate whether post-menopausal hormone therapies present an elevated risk of a heart attack.

22 May 2008

Yerkes researchers develop first transgenic nonhuman primate model of Huntington's disease

In the first study of its kind, researchers at the Yerkes National Primate Research Center, Emory University, in collaboration with researchers from the Department of Human Genetics at Emory's School of Medicine, have developed the first transgenic nonhuman primate model of Huntington's disease (HD), one of the most devastating human neurodegenerative diseases.

22 May 2008

NCI scientists visualize gene regulation in living cells

A research team led by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has applied advanced imaging methods and computer simulations to be able to glance at the regulation of a cancer-related gene in a living cell. They found that the efficiency with which the components of the cell's gene reading machinery come together has an impact on gene expression, the process by which a gene translates its information into a new protein. The findings, published in the May 23, 2008 issue of Molecular Cell, shed new light on the means by which living cells regulate gene activity.

22 May 2008

RNA toxicity contributes to neurodegenerative disease

Expanding on prior research performed at the University of Pennsylvania, Penn biologists have determined that faulty RNA, the blueprint that creates mutated, toxic proteins, contributes to a family of neurodegenerative disorders in humans.

21 May 2008

Scientists reveal the genetic determinants of fat storage in cells

New research by the Gladstone Institutes of Cardiovascular Disease (GICD) and the University of California, San Francisco (UCSF), has revealed the genetic determinants of fat storage in cells, which may lead to a new understanding of and potential treatments for obesity, diabetes, and heart disease. While scientists have long understood that lipid droplets contribute to fat build up in cells, the genes involved in droplet biology have been a focus of extensive research.

21 May 2008

Unique genetic signature alerts physicians to high-risk breast tumors

A unique genetic signature can alert physicians to high-risk breast tumors that are masquerading as low-risk tumors, according to research at Washington University School of Medicine in St. Louis and collaborating institutions. Although these tumors are apparently estrogen-receptor positive - meaning they should depend on estrogen to grow - they don't respond well to anti-estrogen therapy.

21 May 2008

DNA modification seen in colorectal tumors helps predict outcomes, John Wayne Cancer Institute researchers find

An international study led by researchers at the John Wayne Cancer Institute at Saint John's Health Center has found that modifications to DNA found on multiple chromosomes in tumors can help to predict outcomes in patients with early-stage rectal cancer.

21 May 2008

New program promises to solve puzzling medical cases

A new research program in the U.S. promises to provide some answers for people suffering from mysterious diseases that have defied diagnosis.

21 May 2008

Babies born preterm more than twice as likely to have major birth defects as full-term infants

Preterm birth, live birth before 37 completed weeks gestation, is a growing national health crisis, according to the March of Dimes. More than a half million babies are born too soon each year, and the rate continues to rise. Birth defects and preterm birth are the leading causes of infant death.

21 May 2008

New prognostic markers for gastric cancer patients

In standard clinical settings, DNA microarrays are currently unsuitable for routine use. Prognostic classification on formalin-fixed paraffin-embedded tissues is required. In this study, we looked for new molecular markers for identifying the prognosis of gastric cancer patients.

20 May 2008

Targeted therapy can improve outcomes for lung tumors

The first U.S. clinical trial using genetic screening to identify lung tumors likely to respond to targeted therapies supports the use of those drugs as first-line treatment rather than after standard chemotherapy has failed.

20 May 2008

Ideal treatment for potentially fatal heart condition changes with age

Doctors now make more informed decisions on how to treat an electrical disorder of the heart - be it with drugs, an implanted device or nothing - thanks to a series of decades-long, Rochester-based studies.

20 May 2008

Government funds Rochester heart rhythm disorder research into third decade

A team of cardiologists at the University of Rochester Medical Center has won a four-year, $2.3 million grant from the National Institutes of Health (NIH) to continue its study of a cardiac condition that places teens at risk for sudden death. With the latest award, the team will have received continuous NIH funding for 23 years - one of the longest, continuous, investigator-initiated research projects at the University of Rochester.

20 May 2008