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First Edition: December 6, 2011

In today's headlines, a story detailing how the health law is helping Medicare beneficiaries save money on their prescription drug costs.

6 Dec 2011

Combination of metformin and exercise can prevent Type 2 diabetes

Kinesiology researcher Barry Braun of the University of Massachusetts Amherst and colleagues recently reported unexpected results of a study suggests that exercise and one of the most commonly prescribed drugs for diabetes, metformin, each improves insulin resistance when used alone, but when used together, metformin blunted the full effect of a 12-week exercise program in pre-diabetic men and women.

6 Dec 2011

FDA assigns CTIs' pixantrone NDA new PDUFA action date

Cell Therapeutics, Inc. today announced that the U.S. Food and Drug Administration's Division of Oncology Products 1 has notified CTI that CTI's October 2011 resubmitted New Drug Application is considered a complete, Class 2 response to the FDA's April 2010 complete response letter.

6 Dec 2011

Medicare tightening payments for 'big ticket' cardiology and orthopedic procedures in 11 states

In an effort to rein in costs, the Centers for Medicare and Medicaid Services will in 2012 perform an audit before paying for certain cardiology and orthopedic procedures in key states, including Florida.

6 Dec 2011

Fetal exposure to valproate impairs IQ till age six

Researchers in the U.S. and U.K. are conducting an ongoing investigation of the cognitive effect of fetal exposure across four commonly used antiepileptic drugs (AEDs) as part of an NIH-funded Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) Study. An early NEAD analysis found that fetal exposure to valproate impairs IQ at age three.

6 Dec 2011

MorphoSys unveils next-generation antibody technology Ylanthia

MorphoSys AG today unveiled its next-generation antibody technology Ylanthia®. The technology was presented to an audience of specialists at the 2011 Antibody Engineering and Antibody Therapeutics Conference in San Diego. MorphoSys expects Ylanthia to set new standards for therapeutic antibody generation in the pharmaceutical industry over the next decade and beyond. Commercial application will commence in 2012.

6 Dec 2011

Bold move by Astra Zeneca to share 22 early stage potential drugs with MRC

Drug maker AstraZeneca will be sharing 22 of its early-stage research compounds with the Medical Research Council as part of a make over of life sciences research. This would speed up patients’ access to breakthrough drugs and arrest the decline of research and development in the UK.

6 Dec 2011

Cameron says all NHS patients should share their medical data for research

According to British Prime Minister David Cameron, every NHS patient should be a “research patient” with their medical details “opened up” to private healthcare firms. The PM announced that all those who use the NHS in England will be helping in the fight against disease by helping advance research. He hopes the result will be that patients get faster access to new treatments and Britain's life sciences sector will become a world leader.

6 Dec 2011

Roundup: Calif. to drop hospital report cards; Getting a doctor in N.Y. may depend on your neighborhood

The project was considered a pioneering effort when it started in 2004, but Jan Emerson-Shea, a spokesperson for the California Hospital Association, says the report cards have outlived their usefulness. "Today there are numerous places consumers can get information on the quality of care delivered by hospitals," Emerson-Shea says.

6 Dec 2011

New research suggests that teenage texting of nude photos not so popular

Only 1 percent of kids aged 10 to 17 have shared images of themselves or others that involve explicit nudity, a nationally representative study found. Roughly the same number said they'd shared suggestive but less graphic photos; while 7 percent said they'd received either type of picture.

6 Dec 2011

Acupuncture for chemotherapy-induced peripheral neuropathy

Acupuncture may help ease the severe nerve pain associated with certain cancer drugs, suggests a small preliminary study published in Acupuncture in Medicine.

5 Dec 2011

Biogen, Samsung partner to develop and market biosimilars

Samsung and Biogen Idec today announced that they have entered into an agreement to invest $300 million to establish a joint venture to develop, manufacture and market biosimilars. Samsung will take a leading role in the joint venture, with Biogen Idec contributing its expertise in protein engineering and biologics manufacturing.

5 Dec 2011

Stem cells for the damaged heart

Stem cell research got its latest boost. For the first time, stem cells were injected into the hearts of humans who had suffered serious heart damage, and patients improved dramatically. The scientists found that the stem cells grew into new heart cells to replace the damaged tissue.

5 Dec 2011

Genetic variation predicts survival chances of ovarian cancer

Yale Cancer Center researchers have shown that a tiny genetic variation predicts chances of survival and response to treatment for patients with ovarian cancer.

5 Dec 2011

Growth hormone PDGF-BB and blood protein EPO implicated in development of cancer

Researchers at the Swedish medical university Karolinska Institutet have demonstrated that a growth hormone, PDGF-BB, and the blood protein EPO are involved in the development of cancer tumours and that they combine to help the tumours proliferate in the body.

5 Dec 2011

P-Rex1 gene plays a key role in the spread of malignant melanoma

SCIENTISTS in Glasgow have made an important discovery in the fight against malignant melanoma, the most dangerous form of skin cancer.

5 Dec 2011

Study shows new biochemical disturbances in the brains of children with ADHD

A new study at örebro University in Sweden shows that children with ADHD have nearly 50 percent less of a protein that is important for attention and learning. The finding may mean that there are other biochemical disturbances in the brains of individuals with ADHD than was previously believed.

5 Dec 2011

Moffitt investigators to participate with 16 oral and 50 posters presentations at 53rd ASH meeting

When the American Society of Hematology convenes its 53rd Annual Meeting and Exposition on Dec. 10-13 in San Diego, Calif., researchers from Moffitt Cancer Center will break a new record for Moffitt participants with one plenary presentation, 16 oral presentations and more than 50 poster presentations on new research results in a variety of meeting programs that focus on blood cancer basic science and clinical applications, including bone marrow transplantation and clinical trials results.

5 Dec 2011

Cancer cells can 'bag up and bin' a toxic protein to cheat death

Cancer Research UK scientists have discovered that cancer cells can 'bag up and bin' a toxic protein to cheat death - revealing a new Achilles heel in cancer cells that could be targeted for treatment, reveals research in Nature Cell Biology today.

5 Dec 2011

Researchers identify ADHD gene variants involved in glutamate signaling

Pediatric researchers analyzing genetic influences in attention-deficit/hyperactivity disorder (ADHD) have found alterations in specific genes involved in important brain signaling pathways. The study raises the possibility that drugs acting on those pathways might offer a new treatment option for patients with ADHD who have those gene variants—potentially, half a million U.S. children.

5 Dec 2011