Genetic News and Research

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New advance in use of oncolytic viruses as novel cancer treatments

Combining a herpes virus genetically altered to express a drug-enhancing enzyme with a chemotherapy drug effectively and safely reduced the size of highly malignant human sarcoma grafted into mice.

22 Apr 2008

Discovery of gene that may influence metastasis risk in breast cancer

Researchers have identified a pattern of gene activity in mice that may help to predict individual risk for breast cancer metastasis and survival in humans. A single gene, called bromodomain 4 (Brd4), regulates the expression of this pattern, also called a signature.

22 Apr 2008

Orphan Europe files NDA with FDA for Carbaglu (carglumic acid)

Recordati announced the submission to the U.S. FDA by Orphan Europe (a Recordati group company) of an Original New Drug Application (NDA) for Carbaglu (carglumic acid).

21 Apr 2008

Can IT fuel the race to the $1,000 human genome?

Ever wonder if you have a genetic disposition to a certain disease, or why a medicine works for your friend, but not for you?

21 Apr 2008

Sperm "on the rocks" - Using semen cryopreservation to protect amphibian species

A current research project funded by the Austrian Science Fund FWF is working to optimise the cryopreservation of amphibian sperm.

21 Apr 2008

Chronic inflammation triggers cell fusions that could protect neurons

Chronic inflammation triggers bone marrow-derived blood cells to travel to the brain and fuse with a certain type of neuron up to 100 times more frequently than previously believed, according to a new study from the Stanford University School of Medicine.

20 Apr 2008

GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

About 40 percent of African-Americans have a genetic variant that can protect them after heart failure and prolong their lives, according to research conducted at Washington University School of Medicine in St. Louis and collaborating institutions.

20 Apr 2008

A genetic variation mimics effect of heart failure medications - may explain why beta-blockers do not work for all patients

A genetic variation, found predominantly in African Americans, protects some people with heart failure, enabling them to live longer than expected. That's the conclusion of a research team led by investigators at the University of Maryland School of Medicine in Baltimore and the Washington University School of Medicine in St. Louis.

20 Apr 2008

Hypertension all about what you eat and drink

Scientific research on human metabolism based on people from around the world has revealed compounds in urine indicate surprising differences affecting blood pressure.

20 Apr 2008

Simple blood test screens for susceptibilty to meningococcal

A breakthrough in the fight against meningitis and meningococcal disease is apparently already proving to be a lifesaver.

20 Apr 2008

Aida Pharmaceuticals announces development of new anti-cancer drug

Aida Pharmaceuticals, Inc. has announced that it is developing a potential cancer drug that seeks to trigger cell death in certain types of cancer.

18 Apr 2008

Mature B cells reprogrammed to stem-cell-like state

Fully mature, differentiated B cells can be reprogrammed to an embryonic-stem-cell-like state, without the use of an egg, according to a study published in the April 18 issue of Cell.

18 Apr 2008

Keep children's health in mind

If there is any real purpose to the 2020 summit, it could be to establish a national program of research, clinical and community activity that would deliver a 21st century response to the real child and youth mental health problems that our society creates.

18 Apr 2008

First functional insulin-binding protein in invertebrates

Insulin-like growth factor (IGF) signaling that helps to regulate mammals' growth, metabolism, reproduction and longevity is well documented. Now research published in the open access journal Journal of Biology describes the genetic identification of the first functional insulin-like growth factor binding protein (IGFBP) ortholog in invertebrates.

17 Apr 2008

Inherited cancer gene mutation more common than formerly believed

A gene mutation responsible for the most common form of inherited colon cancer is older and more common than formerly believed, according to a recent study.

17 Apr 2008

The mechanism of phosphorus as a cardiovascular risk factor in chronic kidney disease

The estimated 19 million Americans living with chronic kidney disease (CKD) face a high risk of death from cardiovascular disease. Recent studies have shown that a main source of this cardiovascular risk is CKD patients' high levels of blood phosphate.

17 Apr 2008