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Researchers explore how design of chronic and acute pain trials might be improved

For chronic pain sufferers, a day can feel like a year and a year can feel like an eternity. With very few truly new therapies approved by the U.S. Food and Drug Administration for this condition since 2005, the outlook is far from bright.

15 Nov 2011

Risk of heart failure appears to be higher among low-income seniors

The risk of heart failure appears to be higher among low-income seniors — even those with a college education — according to research from the University of Alabama at Birmingham presented during the 2011 American Heart Association Scientific Sessions.

15 Nov 2011

Beer, like wine can reduce risk of cardiovascular disease

Beer could stand up alongside wine regarding positive effects on cardiovascular health. This is the conclusion of a study conducted by Research Laboratories at the Fondazione di Ricerca e Cura "Giovanni Paolo II", in Campobasso, Italy. Both for wine and beer the key is moderate and regular drinking.

15 Nov 2011

New animal research finds life experiences influence brain development, behavior

Scientists presented new research today demonstrating the impact life experiences can have on genes and behavior. The studies examine how such environmental information can be transmitted from one generation to the next - a phenomenon known as epigenetics.

15 Nov 2011

Lentigen, UH Case Medical Center initiate LG631 Phase I trial in glioblastoma

University Hospitals (UH) Case Medical Center, Case Western Reserve University School of Medicine and Lentigen Corporation announced today the initiation of a novel Phase I clinical trial of LG631 gene therapy for the protection of hematopoietic stem cells (HSCs) from the dose limiting toxicity of chemotherapy with Temodar.

15 Nov 2011

Women with inflammatory breast cancer now have a chance of treatment

Women with the deadliest and rarest form of breast cancer now have a chance of treatment where once their options were severely limited, thanks to a new discovery by George Mason University researchers.

15 Nov 2011

Increased access to PMTCT needed to end pediatric AIDS, build an 'AIDS-free generation'

In this post in the Huffington Post's "Impact" blog, Charles Lyons, president and CEO of the Elizabeth Glaser Pediatric AIDS Foundation, responds to Secretary of State Hillary Clinton's speech at the NIH last week in which she called for an "AIDS-free generation," writing, "As Secretary Clinton pointed out, we've never before had as many tools to get ahead of the disease as we do now," such as male circumcision and treatment as prevention, "but one of the cornerstones of her strategy to create an AIDS-free generation is a tool we've actually had in our arsenal for a long time: the ability to prevent mother-to-child transmission of HIV."

14 Nov 2011

Lower glycemic index diet may delay onset of AMD-like lesions

Feeding older mice a lower glycemic index (GI) diet consisting of slowly-digested carbohydrates delays the onset of age-related, sight-threatening retinal lesions, according to a new study from the Laboratory for Nutrition and Vision Research at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University.

14 Nov 2011

Researchers get $7.5M grant to combat nerve agents

A $7.5 million award will help researchers harness the body’s own defenses to counteract nerve agents and create new types of antidotes for exposure to pesticides and other poisons.

14 Nov 2011

Yissum Research and other investors complete additional investment round of $3 million in Avraham Pharmaceuticals

Yissum Research Development Company Ltd., the technology transfer arm of the Hebrew University of Jerusalem, today announced that it has participated in a U.S. $3 million financing round of Avraham Pharmaceuticals Ltd. together with Pontifax, Clal Biotechnology Industries (CBI), Technion Research and Development Foundation Ltd. (TRDF), Professor Marta Weinstock-Rosin and others.

14 Nov 2011

Cancer drug joins list of medicines in short supply

A crucial cancer drug has been in short supply since midsummer - and its maker, Johnson & Johnson Inc., has not been able to remedy the situation since.

14 Nov 2011

Demand for non-drug intervention for atrial fibrillation will remain, despite FDA PVAC decision

According to Millennium Research Group (MRG), the global authority on medical technology market intelligence, the search for an improved method of treating atrial fibrillation (AF) will be unaffected by the recent mixed decision by the Food and Drug Administration (FDA) panel on Medtronic's phased radiofrequency (RF) pulmonary vein ablation catheter (PVAC).

From Medtronic 14 Nov 2011

Simcere third quarter total revenue decreases 8.9% to RMB501.0 million

Simcere Pharmaceutical Group, a leading pharmaceutical company specializing in the development, manufacturing, and marketing of branded generic and proprietary pharmaceuticals in China, today reported preliminary unaudited financial results for the quarter ended September 30, 2011.

14 Nov 2011

Sinovac third quarter sales increase 60.8% to $15.4 million

Sinovac Biotech Ltd., a leading provider of biopharmaceutical products in China, announced today its unaudited third quarter financial results for the period ended September 30, 2011.

14 Nov 2011

First Edition: November 14, 2011

In today's headlines, reports about the Supreme Court's expected health law announcement; about where things stand with the super committee and its fast-approaching deadline; and other health policy news.

14 Nov 2011

TPI first quarter revenue decreases 20.5% to $17.5 million

Tianyin Pharmaceutical Inc., a pharmaceutical company that specializes in the patented biopharmaceutical, modernized traditional Chinese medicine (TCM), branded generics and active pharmaceutical ingredients (API) announced financial results for the first quarter of Fiscal Year 2012.

14 Nov 2011

Luminescent upconversion nanocrystals can detect cancer cells

Upconversion emission materials are ideal for bioimaging due to its effectiveness as contrast agents for the detection of cancer cells, more so when the background emission of non-cancerous tissues can be minimised. These materials could be used as biomarkers for luminescent labeling of cancerous cells. Opaque tissues can be turned into glassy, transparent substances by using these biomarkers which rely on near-infrared excitation.

14 Nov 2011

Scientists discover molecular basis for tamoxifen resistance and potential way to defeat it

In the last three decades, thousands of women with breast cancer have taken the drug tamoxifen, only to discover that the therapy doesn't work, either because their tumors do not respond to the treatment at all, or because they develop resistance to it over time. Now researchers at the University of California, San Francisco (UCSF) have discovered the molecular basis for tamoxifen resistance and found a potential way to defeat it.

14 Nov 2011

Scientists create new phenotypic cancer drug screening platform

Researchers have created a new phenotypic screening platform that better predicts success of drugs developed to prevent blood vessel tumor growth when moving out of the lab and onto actual tumors.

14 Nov 2011

Next-generation drugs may prevent skin lesions in BRAF mutation-positive melanoma

Findings from preclinical studies in a skin cancer model showed that next-generation BRAF inhibitors used alone, or first-generation BRAF inhibitors used in combination with an epidermal growth factor receptor inhibitor, may have the potential to prevent drug-induced skin lesions in BRAF mutation-positive patients treated for melanoma.

14 Nov 2011