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Researchers develop new way to design glycoclusters for targeted drug delivery

A team led by researchers at the RIKEN Biofunctional Synthetic Chemistry Laboratory in Japan has developed a way to engineer glycan complexes--clusters of sugar chains attached to proteins or lipids--in a way that allows the molecules to be transported preferentially to specific organs of the body, depending on the sugar chains contained in the cluster.

29 Nov 2016

Research provides insight into molecular mechanisms involved in immune response to HBV

The innate immune system in mammals defends against infection from viruses and other microbial infections.

28 Nov 2016

Study using Cubresa SPECT scanner finds potential non-invasive diagnosis for Alzheimer’s

Cubresa’s SPECT scanner was used to determine if a novel molecular label, TRV6001, in development for in vivo imaging of the BChE enzyme present in the brains of Alzheimer’s Disease patients follows the known distribution of the enzyme in animal models of the disease.

From Cubresa Inc. 28 Nov 2016

New cell reprogramming mechanism could pave way for potential therapies to boost tissue repair

Researchers have identified a mechanism by which cells undergo reprogramming in live mice, a phenomenon that had previously been poorly understood.

24 Nov 2016

Research reveals key role of fibroblasts in development of rheumatoid arthritis

A study led by researchers at the University of Birmingham reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis (RA), opening up a new avenue for research into treatment of the disease.

23 Nov 2016

TMDU researchers identify novel type of cell death in Huntington's disease

In Huntington's disease (HD), the huntingtin gene is mutated, causing progressive neuronal death.

22 Nov 2016

New hydrogel-based vascular embolization may offer great advantage for treating clotting disorders

Small blood clots called emboli are mostly known for traveling through the vasculature before they lodge and obstruct vessels, impeding blood and oxygen supply to organs like the lung.

16 Nov 2016

Research shows CRAC channel inhibitors decrease lesion size, brain hemorrhage, and neurological deficits in TBI model

Researchers from the San Francisco Veterans Affairs Medical Center and UCSF, and CalciMedica, Inc., are presenting a poster at the 46th annual Society for Neuroscience meeting in San Diego describing the use of calcium release-activated calcium (CRAC) channel inhibitors in traumatic brain injury (TBI).

16 Nov 2016

Genetically engineered bacteria designed with thermostat controls may help treat diseases

A new helper in the fight against cancer and other diseases of the gut may be genetically altered bacteria that release medicines to tumors or the gut.

15 Nov 2016

TSRI study suggests new approach to limit tumor growth by targeting immune system cells

A new study led by scientists at The Scripps Research Institute suggests there may be a way to limit tumor growth by targeting immune system cells called macrophages.

11 Nov 2016

Compugen program shows potential for development of new immunotherapy treatments for solid tumors

Compugen Ltd., a leading predictive drug discovery company, today presented new data for its preclinical CGEN-15029 program demonstrating the potential for the development of new cancer immunotherapy treatments for solid tumors, including the potential for drug combination with current immune checkpoint blockers.

11 Nov 2016

New research shows how synthetic DNA vaccine approach protects against Zika virus infection

As the global spread of the Zika virus continues, efforts are underway to halt the disease's transmission.

10 Nov 2016

Researchers lay foundation for improved TB treatment by targeting new enzyme

Researchers at Johns Hopkins report they have laid the foundation to develop novel antibiotics that work against incurable, antibiotic-resistant bacteria like tuberculosis by targeting an enzyme essential to the production and integrity of bacterial cell walls.

10 Nov 2016

NCATS funds collaboration initiative aimed at repurposing antimalarial to combat Ebola virus

The National Center for Advancing Translational Sciences recently awarded $596,533.00 to Collaborations Pharmaceuticals, Inc. to initiate a partnership with Texas Biomedical Research Institute aimed at repurposing an antimalarial for use against the Ebola virus.

10 Nov 2016

Research reveals mechanism behind progression of neurodegenerative diseases in the brain

Synapses, the place where brain cells contact one another, play a pivotal role in the transmission of toxic proteins. This allows neurodegenerative diseases such as Alzheimer's to spread through the brain.

9 Nov 2016

SCAPE microscopy forms real-time 3D images of living organisms

Mannheim/Wetzlar, Germany. Leica Microsystems CMS GmbH has entered into an exclusive, worldwide licensing agreement with Columbia University in New York to commercialize SCAPE microscopy for Life Science applications. SCAPE (swept confocally aligned planar excitation) microscopy forms 3D images of living samples by scanning them with a sheet of laser light.

From Leica Microsystems GmbH 8 Nov 2016

New treatment with therapeutic short interfering RNA could help thwart cancer

In the fight against cancer, doctors dish out combination-blows of surgery, chemotherapy and other drugs to beat back a merciless foe. Now, scientists have taken early steps toward adding a stinging punch to clinicians' repertoire.

7 Nov 2016

Polysorbate slows toxic effects of E. coli poisoning

Polysorbate, a safe additive found in everything from ice cream to cosmetics, has been proven to slow the toxic effects of E. coli poisoning.

4 Nov 2016

Llama antibodies can detect cerebral lesions that characterize Alzheimer's disease

The major challenge facing physicians treating Alzheimer's is the ability to detect markers of the disease as early as possible. These markers, located in the brain, are difficult to access, hampering diagnosis.

4 Nov 2016

Alcohol-free berry wine could potentially reduce effects of Type 2 diabetes

Blueberries, and berries in general, are among foods labeled as "diabetes superfoods" by the American Association of Diabetes. Food science researchers at the University of Illinois have found that fermenting berries may improve their antidiabetic potential even more.

1 Nov 2016

in vivo News and Research

Researchers develop new way to design glycoclusters for targeted drug delivery

Research provides insight into molecular mechanisms involved in immune response to HBV

Study using Cubresa SPECT scanner finds potential non-invasive diagnosis for Alzheimer’s

New cell reprogramming mechanism could pave way for potential therapies to boost tissue repair

Research reveals key role of fibroblasts in development of rheumatoid arthritis

TMDU researchers identify novel type of cell death in Huntington's disease

New hydrogel-based vascular embolization may offer great advantage for treating clotting disorders

Research shows CRAC channel inhibitors decrease lesion size, brain hemorrhage, and neurological deficits in TBI model

Genetically engineered bacteria designed with thermostat controls may help treat diseases

TSRI study suggests new approach to limit tumor growth by targeting immune system cells

Compugen program shows potential for development of new immunotherapy treatments for solid tumors

New research shows how synthetic DNA vaccine approach protects against Zika virus infection

Researchers lay foundation for improved TB treatment by targeting new enzyme

NCATS funds collaboration initiative aimed at repurposing antimalarial to combat Ebola virus

Research reveals mechanism behind progression of neurodegenerative diseases in the brain

SCAPE microscopy forms real-time 3D images of living organisms

New treatment with therapeutic short interfering RNA could help thwart cancer

Polysorbate slows toxic effects of E. coli poisoning

Llama antibodies can detect cerebral lesions that characterize Alzheimer's disease

Alcohol-free berry wine could potentially reduce effects of Type 2 diabetes

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

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The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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