Preclinical News and Research

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Heart failure drug could be effective in treating leukemia

Canadian researchers followed their intuition that a drug initially intended for heart failure could be effective in treating cancer. Those efforts have borne fruit, as demonstrated by their work published in the Journal of Experimental and Clinical Cancer Research.

13 Jun 2019

Apolipoproten E appears to be new potential druggable target for Alzheimer's

Apolipoproten E is a major genetic risk factor for the development of Alzheimer's disease, yet the protein tends to be understudied as a potential druggable target for the mind-robbing neurodegenerative disease.

13 Jun 2019

UAMS-developed noninvasive device detects melanoma in earliest stages

A University of Arkansas for Medical Sciences research team led by Vladimir Zharov, Ph.D., D.Sc., has demonstrated the ability to detect and kill circulating tumor cells in the blood using a noninvasive device called Cytophone that integrates a laser, ultrasound and phone technologies.

13 Jun 2019

Drink containing multinutrient combination can benefit patients with mild cognitive impairment

Study supports the hypothesis that a food for special medical purposes containing Fortasyn Connect® can benefit patients with mild cognitive impairment who are at high risk of progression to the dementia stage of Alzheimer's disease, according to research published in the Journal of Alzheimer's Disease Reports

13 Jun 2019

Amsterdam University Medical Center wins MR Solutions’ Image of the Year 2019 award

The Amsterdam University Medical Center has won MR Solutions’ Image of the Year 2019 award for the best molecular research image

From MR Solutions 12 Jun 2019

Women have better memories of events than men

Memories of events, episodic memory, is better amongst women compared to men, researchers from Karolinska Institutet in Sweden have found in a new overview published in the scientific journal Psychological Bulletin.

12 Jun 2019

Early life adversity and high levels of FKBP5 protein amplify anxiety-like behavior

Researchers continue to dig for molecular clues to better understand how gene-environment interactions influence neuropsychiatric disease risk and resilience.

11 Jun 2019

A 'one-two punch' approach to destroy cancerous ovarian cells

Researchers from the University of Montreal Hospital Research Centre have developed a two-step combination therapy to destroy cancer cells.

11 Jun 2019

Novel agent shown to have dual mechanism of action to eliminate cancer

Results from a study spearhead by researchers at the Vall d´Hebron Institute of Oncology (VHIO), show that the blockade of the multi-functional cytokine LIF induces tumor-infiltrating T Cells to hone in on and eliminate cancer.

11 Jun 2019

Bioventus and MTF Biologics collaborate to develop placental tissue product for knee osteoarthritis

Bioventus, a global leader in orthobiologic solutions, has entered into a development collaboration agreement with MTF Biologics, the world’s largest tissue bank, to co-develop a next generation placental tissue product for the treatment of painful musculoskeletal conditions, with an initial focus on knee osteoarthritis.

10 Jun 2019

Researchers investigate how antibiotic produced by the microbiome kills bacteria

A research team from the Universities of Tübingen and Göttingen as well as from the German Center for Infection Research has investigated the mode of action of a new class of antibiotics that is highly effective against multidrug-resistant pathogens.

4 Jun 2019

Researchers develop novel imaging test to predict immunotherapy response in kidney cancer

A novel imaging test shows promise for identifying kidney cancer patients most likely to benefit from immunotherapy.

4 Jun 2019

Lithium improves muscle size and strength in mice with limb girdle muscular dystrophy

Standing up from a chair, climbing stairs, brushing one's hair - all can be a struggle for people with a rare form of muscular dystrophy that causes progressive weakness in the shoulders and hips. Over time, many such people lose the ability to walk or to lift their arms above their heads.

3 Jun 2019

Combination immunotherapy shows promise in pre-surgical setting for early-stage lung cancers

Neoadjuvant, or pre-surgical, treatment with nivolumab plus ipilimumab resulted in an overall major pathologic response rate of 33 percent of treated patients with early-stage, resectable non-small cell lung cancers, meaning these patients had less than or equal to 10 percent viable tumor remaining at surgery.

3 Jun 2019

Microorganisms on explanted pedicle screws could be potential cause for spinal implant failure

Pedicle screws are often used to secure surgically implanted hardware to the spine in patients with spinal disease or spinal trauma. In some cases, these screws loosen over time, leading to spinal instability and consequent pain.

28 May 2019

Study demonstrates the concept of systemic gene therapy treatment for gamma-sarcoglycanopathy

Gamma-sarcoglycanopathy is one of the most common limb-girdle myopathies.

25 May 2019

Infants at high risk for autism are less attuned to differences in speech patterns

A new study by Columbia University researchers found that infants at high risk for autism were less attuned to differences in speech patterns than low-risk infants.

25 May 2019

WFIRM researchers engineer vascularized functional renal tissues for kidney regeneration

Wake Forest Institute for Regenerative Medicine researchers have shown the feasibility of bioengineering vascularized functional renal tissues for kidney regeneration, developing a partial augmentation strategy that may be a more feasible and practical approach than creating whole organs.

24 May 2019

Children's Tumor Foundation establishes significant research initiative to combat NF2

On the occasion of World NF2 Awareness Day, the Children's Tumor Foundation has announced the establishment of a significant research initiative dedicated to finding effective treatments for NF2, along with a substantial investment of $2.3 million in this bold new effort.

23 May 2019

Cannabidiol reduces cue-induced craving and anxiety in individuals with history of heroin abuse

Cannabidiol reduced cue-induced craving and anxiety in individuals with a history of heroin abuse, suggesting a potential role for it in helping to break the cycle of addiction, according to research conducted at the Icahn School of Medicine at Mount Sinai and published May 21 in the American Journal of Psychiatry.

21 May 2019

Preclinical News and Research

Heart failure drug could be effective in treating leukemia

Apolipoproten E appears to be new potential druggable target for Alzheimer's

UAMS-developed noninvasive device detects melanoma in earliest stages

Drink containing multinutrient combination can benefit patients with mild cognitive impairment

Amsterdam University Medical Center wins MR Solutions’ Image of the Year 2019 award

Women have better memories of events than men

Early life adversity and high levels of FKBP5 protein amplify anxiety-like behavior

A 'one-two punch' approach to destroy cancerous ovarian cells

Novel agent shown to have dual mechanism of action to eliminate cancer

Bioventus and MTF Biologics collaborate to develop placental tissue product for knee osteoarthritis

Researchers investigate how antibiotic produced by the microbiome kills bacteria

Researchers develop novel imaging test to predict immunotherapy response in kidney cancer

Lithium improves muscle size and strength in mice with limb girdle muscular dystrophy

Combination immunotherapy shows promise in pre-surgical setting for early-stage lung cancers

Microorganisms on explanted pedicle screws could be potential cause for spinal implant failure

Study demonstrates the concept of systemic gene therapy treatment for gamma-sarcoglycanopathy

Infants at high risk for autism are less attuned to differences in speech patterns

WFIRM researchers engineer vascularized functional renal tissues for kidney regeneration

Children's Tumor Foundation establishes significant research initiative to combat NF2

Cannabidiol reduces cue-induced craving and anxiety in individuals with history of heroin abuse

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