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Environmental toxicants contribute to obesity and metabolic disease

In a recent study published in the Current Opinion in Pharmacology journal, researchers assessed the impact of environmental toxicants and brown adipose tissue (BAT) on obesity and metabolic disorders.

4 Nov 2022

Fermented dairy products can improve gut mucosal immunity

In a recent study published in the journal Immunology Letters, researchers assessed the role of fermented dairy products and dairy starters in modulating gut mucosal immunity.

3 Nov 2022

Circadian disruption induces weight gain through changes in gut microbiota

In a recent study published in the journal Molecular Metabolism, researchers investigated the impact of environmental and genetic disruptions of the circadian rhythms on the peripheral circadian clock synchronization and microbiome oscillations in the gastrointestinal tract.

3 Nov 2022

Weekly weight loss drug reduces BMI in teens

Researchers report that a weekly dose of semaglutide led to a significant BMI reduction in adolescents.

3 Nov 2022

Novel monoclonal antibodies NA8 and NE12 can neutralize most SARS-CoV-2 variants and Omicron subvariants

Researchers generated and characterized two monoclonal antibodies (NA8 and NE12) that target the receptor binding domain of the SARS-CoV-2 spike protein, and exhibit neutralizing activity against major SARS-CoV-2 variants of concern.

3 Nov 2022

Investigating the role of the gut-to-brain axis in defensive responses

In a new study, researchers investigated the function of the gut-to-brain axis in defensive responses induced by toxins.

3 Nov 2022

Gut colonization by proteobacteria modulates mice’s neurobehavioral response to cocaine

A new study revealed that gut colonization by proteobacteria modulates cocaine neurobehavioral response in mice.

3 Nov 2022

Scientists identify a cryptic SARS-CoV-2 lineage in wastewater

In a recent study posted to the medRxiv* preprint server, researchers in the United States investigated the source of an enigmatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC)-like spike (S) protein strain detected in wastewater but not in clinical samples.

2 Nov 2022

Vimentin is an important co-receptor for SARS-CoV-2 infection

Vimentin functions as a co-receptor for the entry of SARS-CoV-2 into host cells to facilitate infection.

2 Nov 2022

Bivalent mRNA booster broadens humoral immunity against SARS-CoV-2 Omicron subvariants

Researchers at Emory University, Stanford University, and the National Institute of Allergy and Infectious Diseases evaluated whether bivalent coronavirus disease 2019 (COVID-19) boosters conferred protection against new Omicron subvariants.

2 Nov 2022

Scientists identify a broadly neutralizing antibody against all dominant SARS-CoV-2 variants

Researchers in the United States identified a broadly neutralizing antibody (S728-1157 bnAb) that targets the receptor-binding site (RBS) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Nov 2022

Dietary inulin fiber can promote allergy-related type of inflammation in the gut and lungs

A type of dietary fiber called inulin, commonly used in health supplements and known to have certain anti-inflammatory properties, can also promote an allergy-related type of inflammation in the lung and gut, and other parts of the body, according to a preclinical study from researchers in the Friedman Center for Nutrition and Inflammation and Jill Roberts Institute for Inflammatory Bowel Disease at Weill Cornell Medicine and in the Boyce Thompson Institute on Cornell's Ithaca campus.

2 Nov 2022

Researchers identify new therapeutic approach against treatment-resistant prostate cancer

Investigators from Cedars-Sinai Cancer have identified an investigational therapeutic approach that could be effective against treatment-resistant prostate cancer. Results of their Phase II clinical trial, published in the peer-reviewed journal Molecular Therapy, have led to a larger, multicenter trial that will soon be underway.

2 Nov 2022

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

A new study aimed to analyze the molecular interactions between the hCypA protein and the SARS-CoV-2 variants to determine the impact of variants on the blocking and binding potential of the hCypA–S protein complex with the ACE2 receptor.

2 Nov 2022

How does imprinted SARS-CoV-2 humoral immunity drive convergent Omicron evolution?

Researchers examined how imprinted SARS-CoV-2 humoral immunity drives convergent evolution in continuously emerging Omicron subvariants.

2 Nov 2022

UT Southwestern study uncovers a causative signaling pathway in breast cancer

UT Southwestern researchers have identified a causative signaling pathway in breast cancer, providing potential new targets for treatment of the most common type of cancer in women.

1 Nov 2022

Study provides insight into how sleep and wakefulness regulate inhibitory synapses

Using a mouse model, researchers have discovered a new daily rhythm in a type of synapse that dampens brain activity.

1 Nov 2022

EULAR points-to-consider can guide diagnostic evaluation, treatment and monitoring of SAIDs

SAIDs are a group of multi-system disorders caused by dysfunction in the innate immune system. A number of these SAIDs are mediated by a cytokine called interleukin-1 (IL-1), including the cryopyrin-associated periodic syndromes (CAPS), tumor necrosis factor receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD), and deficiency of the IL-1 receptor antagonist (DIRA).

1 Nov 2022

Progress and challenges in the development of mRNA vaccines against respiratory syncytial virus

New research discussed the structure and life cycle of respiratory syncytial virus (RSV), the current research on the treatment and prevention of RSV infections, and the advancements in RSV mRNA vaccine technology after the surge in vaccine research during the COVID-19 pandemic.

1 Nov 2022

Protein kinase CK2 controls CD8+ T cell effector and memory functions during Listeria infection

The protein kinase CK2 is involved in a wide range of biological processes and cellular functions, including inflammatory responses and pathologies associated with inflammation.

1 Nov 2022

Receptor News and Research

Environmental toxicants contribute to obesity and metabolic disease

Fermented dairy products can improve gut mucosal immunity

Circadian disruption induces weight gain through changes in gut microbiota

Weekly weight loss drug reduces BMI in teens

Novel monoclonal antibodies NA8 and NE12 can neutralize most SARS-CoV-2 variants and Omicron subvariants

Investigating the role of the gut-to-brain axis in defensive responses

Gut colonization by proteobacteria modulates mice’s neurobehavioral response to cocaine

Scientists identify a cryptic SARS-CoV-2 lineage in wastewater

Vimentin is an important co-receptor for SARS-CoV-2 infection

Bivalent mRNA booster broadens humoral immunity against SARS-CoV-2 Omicron subvariants

Scientists identify a broadly neutralizing antibody against all dominant SARS-CoV-2 variants

Dietary inulin fiber can promote allergy-related type of inflammation in the gut and lungs

Researchers identify new therapeutic approach against treatment-resistant prostate cancer

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

How does imprinted SARS-CoV-2 humoral immunity drive convergent Omicron evolution?

UT Southwestern study uncovers a causative signaling pathway in breast cancer

Study provides insight into how sleep and wakefulness regulate inhibitory synapses

EULAR points-to-consider can guide diagnostic evaluation, treatment and monitoring of SAIDs

Progress and challenges in the development of mRNA vaccines against respiratory syncytial virus

Protein kinase CK2 controls CD8+ T cell effector and memory functions during Listeria infection

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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