Clinical Trial News and Research

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New study points to a strategy for inhibiting hyper-progression of melanoma

Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma cells instead of unleashing the immune system to fight them.

23 Nov 2022

High-risk stage III-IV melanoma patients treated with pembrolizumab report better quality of life

Patients with high-risk stage III-IV melanoma who received pembrolizumab after their surgery reported a better quality of life than patients who received the previous standard-of-care treatment with either ipilimumab or high-dose interferon.

23 Nov 2022

Vitamin D appears to have no substantial impact on statin-related muscle pain

Patients who take statins to lower high cholesterol levels often complain of muscle pains, which can lead them to stop taking the highly effective medication and put them at greater risk of heart attack or stroke.

23 Nov 2022

Single drug compound may offer a promising new strategy for treating prostate cancer patients

A single drug compound simultaneously attacks hard-to-treat prostate cancer on several fronts, according to a new study in mice and human cells.

23 Nov 2022

MiRNAs can be used as a biomarker to predict disease recurrence and mortality in breast cancer patients

Researchers at University of Galway have determined that biomarkers known as microRNAs can help predict which patients with breast cancer are likely to face a recurrence of the disease and death.

23 Nov 2022

Creating New Targeted Antibacterial Products to Help Tackle Antimicrobial Resistance

We speak to Matthew Dunne, Director for Drug Discovery at Micreos Pharmaceuticals, about the importance of creating new targeted antibacterial products.

22 Nov 2022

Approved and developing passive and active immunizations against respiratory syncytial virus in childhood and pregnancy

Researchers explored active and passive vaccination among children against respiratory syncytial virus (RSV).

22 Nov 2022

Johns Hopkins experts receive PCORI funding to optimize antibiotic therapy for gram-negative bloodstream infections

To study how best to treat potentially dangerous infections commonly seen in people with underlying chronic medical conditions, two infectious disease experts at Johns Hopkins Medicine have been awarded $10 million in research funding over five years by the Patient-Centered Outcomes Research Institute.

21 Nov 2022

Tumor matrix profiles determine the risk and prognosis of a common type of lung cancer

Scientists at the Garvan Institute of Medical Research have identified molecular profiles of the surrounding matrix of a common type of lung cancer that might indicate which patients are likely to develop aggressive tumors.

21 Nov 2022

Exercise may make radiotherapy more tolerable for breast cancer patients

Breast cancer is the most common form of the disease among women; in Australia, one in eight women will be diagnosed with breast cancer by the age of 85.

21 Nov 2022

Does influenza vaccination reduce death and vascular events in patients with heart failure?

Researchers conducted a placebo-controlled, double-blind clinical trial to assess whether influenza vaccination effectively reduced vascular events and mortality among patients with heart failure.

21 Nov 2022

Kessler and BrainQ partner on a national trial of breakthrough device to improve recovery after stroke

Researchers from Kessler Foundation and Kessler Institute for Rehabilitation (collectively "Kessler") are enrolling participants in a national trial of a breakthrough device for improving recovery after stroke. Kessler locations in West Orange and Saddle Brook, NJ, are among the 20 sites across the U.S. participating in the EMAGINE Stroke Recovery Trial, which pairs therapeutic exercise with stimulation of the brain through an investigational wearable device.

20 Nov 2022

Researchers develop new device to non-invasively measure cervical nerve activity

A team of engineers and physicians at University of California San Diego has developed a device to non-invasively measure cervical nerve activity in humans, a new tool that they say could potentially inform and improve treatments for patients with sepsis, a life-threatening response to infection, and mental health conditions, such as post-traumatic stress disorder (PTSD).

20 Nov 2022

New approach for delivering medication across the blood-brain barrier to treat brain tumors

Researchers have demonstrated in mice a new approach for delivering medication across the blood-brain barrier to treat tumors that cause aggressive, lethal brain cancer.

20 Nov 2022

As STDS proliferate, companies rush to market at-home test kits. But are they reliable?

Among the more remarkable legacies of the covid-19 pandemic is how quickly federal regulators, the health care industry, and consumers moved to make at-home testing a reliable tool for managing a public health crisis.

20 Nov 2022

Machine learning algorithm predicts a tumor’s response to immune checkpoint blockade

Predicting which patients will respond well to treatment is a quandary that has plagued the field of cancer immunotherapy for more than four decades.

16 Nov 2022

Can a multicultural healthy diet reduce cognitive decline and Alzheimer's disease risk?

Scientists conducted a pilot randomized controlled clinical trial to investigate whether a multicultural healthy diet can reduce cognitive decline and Alzheimer’s disease risk in adults aged 40 – 65.

16 Nov 2022

Whole-genome sequencing reveals five new subgroups of chronic lymphocytic leukemia

A collaborative study led by the University of Oxford as part of the UK's 100,000 Genomes Project, published in Nature Genetics today, has defined five new subgroups of the most common type of blood cancer, chronic lymphocytic leukemia (CLL) and associated these with clinical outcomes.

16 Nov 2022

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Researchers at the University of Michigan Rogel Cancer Center have identified a novel treatment approach to an aggressive type of pediatric brain cancer, using therapies already approved to treat cancer.

16 Nov 2022

Black, Hispanic MSM disproportionately affected by monkeypox

A recent study published in the Morbidity and Mortality Weekly Report described the epidemiologic characteristics of the monkeypox (MPX) outbreak in the United States (US).

15 Nov 2022

Clinical Trial News and Research

New study points to a strategy for inhibiting hyper-progression of melanoma

High-risk stage III-IV melanoma patients treated with pembrolizumab report better quality of life

Vitamin D appears to have no substantial impact on statin-related muscle pain

Single drug compound may offer a promising new strategy for treating prostate cancer patients

MiRNAs can be used as a biomarker to predict disease recurrence and mortality in breast cancer patients

Creating New Targeted Antibacterial Products to Help Tackle Antimicrobial Resistance

Approved and developing passive and active immunizations against respiratory syncytial virus in childhood and pregnancy

Johns Hopkins experts receive PCORI funding to optimize antibiotic therapy for gram-negative bloodstream infections

Tumor matrix profiles determine the risk and prognosis of a common type of lung cancer

Exercise may make radiotherapy more tolerable for breast cancer patients

Does influenza vaccination reduce death and vascular events in patients with heart failure?

Kessler and BrainQ partner on a national trial of breakthrough device to improve recovery after stroke

Researchers develop new device to non-invasively measure cervical nerve activity

New approach for delivering medication across the blood-brain barrier to treat brain tumors

As STDS proliferate, companies rush to market at-home test kits. But are they reliable?

Machine learning algorithm predicts a tumor’s response to immune checkpoint blockade

Can a multicultural healthy diet reduce cognitive decline and Alzheimer's disease risk?

Whole-genome sequencing reveals five new subgroups of chronic lymphocytic leukemia

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Black, Hispanic MSM disproportionately affected by monkeypox

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