Compound News and Research

RSS

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but proguanil, which is widely used for the prevention of malaria, does not.

12 Aug 2016

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments.

11 Aug 2016

Antioxidant compound could be effective to combat immune rejection after islet transplantation

A team of researchers has found that doses of bilirubin help provide suppression of the immune response following islet transplantation in mouse models.

11 Aug 2016

Gut microbiome can influence common dietary compound linked to heart disease

In the last five years, some scientists have cautioned against eating eggs and meat because these foods generate a common dietary compound, trimethylamine N-oxide (TMAO), that research has suggested plays a role in heart disease.

11 Aug 2016

Gene mutation linked to impulsive drunken behaviour shields bearers from obesity, insulin resistance

University of Helsinki researchers have previously demonstrated that a point mutation in a gene of serotonin 2B receptor can render the carrier prone to impulsive behaviour, particularly when drunk.

10 Aug 2016

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Maintaining proper levels of an essential helper molecule is crucial for optimal muscle function, according to a study led by Joseph Baur, PhD, an assistant professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2016

CTCA at Western begins clinical trial for novel antibody to treat patients with advanced tumors

Cancer Treatment Centers of America at Western Regional Medical Center has dosed its first three patients as part of the launch of a Phase I clinical trial using a novel antibody to treat patients with advanced solid tumors.

8 Aug 2016

New compound could kill parasites of three neglected diseases

Scientists have identified a compound that can kill the parasites responsible for three neglected diseases: Chagas disease, leishmaniasis and sleeping sickness.

8 Aug 2016

Novel compound holds potential for next-generation prostate cancer treatment

In the search for new ways to attack recurrent prostate cancer, researchers at Duke Health report that a novel compound appears to have a unique way of blocking testosterone from fueling the tumors in mice.

8 Aug 2016

Some WADA-banned substances may have potential medical applications

As the world awaits the start of the 2016 Summer Olympics, doping in athletes remains a hot topic.

4 Aug 2016

Lower weight late in life linked to greater risk for Alzheimer's disease

Researchers at Brigham and Women's Hospital and Massachusetts General Hospital have found an association between lower weight and more extensive deposits of the Alzheimer's-associated protein beta-amyloid in the brains of cognitively normal older individuals.

2 Aug 2016

Imprimis announces availability of new MaxRx Prescriber Portal

Imprimis Pharmaceuticals, Inc., a pharmaceutical company dedicated to making drugs affordable again through its Branded Compounding business model, today announced the availability of its new MaxRx Prescriber Portal, a software application that provides physicians with new order entry and management tools that have traditionally not been available for compounded prescriptions.

30 Jul 2016

W. Nuhsbaum to provide Leica microscopy and digital imaging solutions in Tennessee

Leica Microsystems, a technology leader with a 160-year history of providing best-in-class precision microscopy and digital micro-imaging solutions, announces a strategic expansion in its market representation in Tennessee.

30 Jul 2016

Wearable sensor system could help detect lactate levels in perspiration

It may be clammy and inconvenient, but human sweat has at least one positive characteristic - it can give insight to what's happening inside your body.

28 Jul 2016

Resveratrol may be clinically beneficial to people with Alzheimer's disease

Resveratrol, given to Alzheimer's patients, appears to restore the integrity of the blood-brain barrier, reducing the ability of harmful immune molecules secreted by immune cells to infiltrate from the body into brain tissues, say researchers at Georgetown University Medical Center.

28 Jul 2016

TSRI scientists develop new dual-targeting drug candidate for treating diabetes and bone disease

In addition to its more obvious ills, type 2 diabetes is a condition closely associated with bone fractures, increasing the risk of fractures twofold. To make matters worse, certain anti-diabetic drugs further increase this risk, particularly in postmenopausal women, severely limiting their treatment options.

28 Jul 2016

Compound News and Research

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

Antioxidant compound could be effective to combat immune rejection after islet transplantation

Gut microbiome can influence common dietary compound linked to heart disease

Gene mutation linked to impulsive drunken behaviour shields bearers from obesity, insulin resistance

Penn study sheds light on role of essential compound in maintaining optimal muscle function

CTCA at Western begins clinical trial for novel antibody to treat patients with advanced tumors

New compound could kill parasites of three neglected diseases

Novel compound holds potential for next-generation prostate cancer treatment

Some WADA-banned substances may have potential medical applications

Lower weight late in life linked to greater risk for Alzheimer's disease

Imprimis announces availability of new MaxRx Prescriber Portal

W. Nuhsbaum to provide Leica microscopy and digital imaging solutions in Tennessee

Wearable sensor system could help detect lactate levels in perspiration

Resveratrol may be clinically beneficial to people with Alzheimer's disease

TSRI scientists develop new dual-targeting drug candidate for treating diabetes and bone disease

Researchers identify new mechanisms capable of suppressing propagation of HCV

Study finds link between eczema and S. aureus bacteria

Promising new therapeutic target could lead to better prognosis of spinal muscular atrophy

Combination of two plant compounds holds promise in treating colon cancer

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Latest News