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Clinical trial uses personalized cellular therapy to treat GVHD complication of bone marrow transplant

An innovative clinical trial using the science of "personalized" cellular therapy has begun enrolling children and adults suffering from graft-versus-host-disease (GVHD), a life-threatening complication of bone marrow transplantation in which donor immune lymphocytes attack the organs of the bone marrow transplant recipient.

3 Apr 2015

Peripheral inflammatory cells play role in Parkinson's disease

A small area in the midbrain known as the substantia nigra is the control center for all bodily movement. Increasing loss of dopamine-generating neurons in this part of the brain therefore leads to the main symptoms of Parkinson's disease - slowness of movement, rigidity and shaking.

3 Apr 2015

Mouse model may help understand the physiology behind complex brain disorders

Complex brain disorders, such as autism or schizophrenia, still puzzle scientists because their causes lie hidden in early events of brain development, which are still poorly understood.

3 Apr 2015

Leukemia drug could prevent and control growth of colorectal tumours

Scientists from Nanyang Technological University (NTU Singapore) and Sweden's Karolinska Institutet, one of Europe's largest and most prestigious medical universities, have discovered that an existing chemotherapy drug used to treat leukaemia could prevent and control the growth of colorectal tumours.

3 Apr 2015

Research may point to new paradigms in diagnosis, treatment of aggressive cancers

All living things--from dandelions to reindeer--evolve over time. Cancer cells are no exception, and are subject to the two overarching mechanisms described by Charles Darwin: chance mutation and natural selection.

3 Apr 2015

Thomas Jefferson University, Exosome Sciences team up to evaluate new liquid biopsy platform

Today, Thomas Jefferson University announces a partnership with Exosome Sciences Inc. to evaluate a novel liquid biopsy platform that might offer clinicians new and actionable information about a patient's cancer as the disease progresses and changes, via a simple blood test.

3 Apr 2015

MRSA bacteria exposed to cigarette smoke become more resistant to antimicrobial peptides

Methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic-resistant superbug, can cause life-threatening skin, bloodstream and surgical site infections or pneumonia. Researchers at the University of California, San Diego School of Medicine now report that cigarette smoke may make matters worse.

3 Apr 2015

Pseudogenes may play role in cancer development, shows study

Pseudogenes, a sub-class of long non-coding RNA (lncRNA) that developed from the genome's 20,000 protein-coding genes but lost the ability to produce proteins, have long been considered nothing more than genomic "junk." Yet the retention of these 20,000 mysterious remnants during evolution has suggested that they may in fact possess biological functions and contribute to the development of disease.

3 Apr 2015

Researchers test effects of light therapy on brain function

Following up on promising results from pilot work, researchers at the VA Boston Healthcare System are testing the effects of light therapy on brain function in veterans with Gulf War Illness.

3 Apr 2015

SGI-DNA introduces BioXp system to give researchers priority access to personal DNA work station

SGI-DNA Inc. today announced the launch of the BioXp 3200 System Early Access Program giving researchers priority access to this one of a kind, personal DNA work station which delivers high quality synthetic DNA fragments.

2 Apr 2015

Study: 'Open' stem cell chromosomes hold great promise for treating liver, pancreas diseases

Stem cells hold great promise for treating a number of diseases, in part because they have the unique ability to differentiate, specializing into any one of the hundreds of cell types that comprise the human body.

2 Apr 2015

Olympus unveils CX23® microscope for education, training and laboratory use

Olympus has unveiled the CX23® microscope, designed to provide high-quality optical performance and stress-free, dependable operation in laboratory, classroom and training facilities worldwide.

From Evident Corporation - Life Sciences 2 Apr 2015

Researchers pinpoint molecular mechanisms that inhibit Hippo pathway in pediatric bone cancers

A particular molecular pathway permits stem cells in pediatric bone cancers to grow rapidly and aggressively, according to researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center.

2 Apr 2015

Treating common gum disease in CKD patients could reduce heart disease risk

Treating a common gum condition in chronic kidney disease (CKD) patients could significantly reduce their risk of potentially fatal heart disease, Aston University researchers say.

2 Apr 2015

Scientists develop new type of carrier that combines photosensitivity and magnetism to fight cancer

By combining, in a liposome, magnetic nanoparticles and photosensitizers that are simultaneously and remotely activated by external physical stimuli (a magnetic field and light), scientists at the Laboratoire Matière et Systèmes Complexes (CNRS/Université Paris Diderot) and the Laboratoire Physicochimie des Electrolytes et Nanosystèmes Interfaciaux (CNRS/UPMC), obtained total tumor regression in mice.

2 Apr 2015

Penn Med's BLINKER Team named one of 16 finalists in NIH 'Follow that Cell Challenge'

James Eberwine, PhD, the Elmer Holmes Bobst Professor of Systems Pharmacology and Experimental Therapeutics, at the Perelman School of Medicine at the University of Pennsylvania, was named one of 16 finalists in the first phase of the Follow that Cell Challenge funded by the National Institutes of Health. The competition was run by crowdsourcing company Innocentive and 687 designated "solvers" entered initially.

2 Apr 2015

Scientists develop computer model to predict how liver stores fat

As part of an effort to understand how an experimental drug for atherosclerosis causes the build-up of fat in the liver, scientists have developed a computer model that can predict how the rate at which liver stores fat in response to various situations. Being able to model liver fat storage gives researchers a way to predict the side effects of drugs and environmental factors at much earlier stages in the research and drug development process, possibly reducing the number of experiments involving animal models.

2 Apr 2015

Purdue researchers identify new class of chemical insecticides to control mosquitoes

Purdue researchers have identified a new class of chemical insecticides that could provide a safer, more selective means of controlling mosquitoes that transmit key infectious diseases such as dengue, yellow fever and elephantiasis.

2 Apr 2015

Novel molecule inhibits cancer-causing transcription factors

A novel molecule designed by scientists at the University of Massachusetts Medical School and the University of Virginia inhibits progression of a hard-to-treat form of recurring acute myeloid leukemia (AML) in patient tissue.

2 Apr 2015

Scientists uncover the genetic root of prostate cancer

Scientists have revealed the root of prostate cancers in individual men, discovering that despite huge genetic variety between tumours they also share common gene faults - insight that could offer new treatment hopes, according to research published in Nature today (Wednesday).

2 Apr 2015

B Cell News and Research

Clinical trial uses personalized cellular therapy to treat GVHD complication of bone marrow transplant

Peripheral inflammatory cells play role in Parkinson's disease

Mouse model may help understand the physiology behind complex brain disorders

Leukemia drug could prevent and control growth of colorectal tumours

Research may point to new paradigms in diagnosis, treatment of aggressive cancers

Thomas Jefferson University, Exosome Sciences team up to evaluate new liquid biopsy platform

MRSA bacteria exposed to cigarette smoke become more resistant to antimicrobial peptides

Pseudogenes may play role in cancer development, shows study

Researchers test effects of light therapy on brain function

SGI-DNA introduces BioXp system to give researchers priority access to personal DNA work station

Study: 'Open' stem cell chromosomes hold great promise for treating liver, pancreas diseases

Olympus unveils CX23® microscope for education, training and laboratory use

Researchers pinpoint molecular mechanisms that inhibit Hippo pathway in pediatric bone cancers

Treating common gum disease in CKD patients could reduce heart disease risk

Scientists develop new type of carrier that combines photosensitivity and magnetism to fight cancer

Penn Med's BLINKER Team named one of 16 finalists in NIH 'Follow that Cell Challenge'

Scientists develop computer model to predict how liver stores fat

Purdue researchers identify new class of chemical insecticides to control mosquitoes

Novel molecule inhibits cancer-causing transcription factors

Scientists uncover the genetic root of prostate cancer

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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