Apolipoprotein News and Research

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Researchers test new drug to treat patients with chylomicronemia syndrome

People with familial chylomicronemia syndrome are born with a genetic mutation that means they can't produce an enzyme called lipoprotein lipase.

9 Aug 2019

APOE gene variant may be protective and prolong life, finds study

A new study of 38,537 persons of European ancestry suggests that a rare variation of a gene called APOE may be protective and prolong life, in sharp contrast to a more widely studied APOE variant that increases risk of death.

7 Aug 2019

Glowing cholesterol helps researchers to fight cardiovascular disease

A newly developed technique that shows artery clogging fat-and-protein complexes in live fish gave investigators from Carnegie, Johns Hopkins University, and the Mayo Clinic a glimpse of how to study heart disease in action.

31 Jul 2019

Randox unveils innovative test for risk assessment of cardiovascular disease

Global diagnostics company Randox Laboratories has unveiled an innovative new test for the risk assessment of cardiovascular disease at this year's AACC Clinical Lab Expo in Anaheim, California.

26 Jul 2019

Alzheimer's gene may affect cognitive health before adulthood, study finds

The Apolipoprotein E (APOE) is a major cholesterol carrier that aids in lipid transport and injury repair in the brain. It packages cholesterol and other fats and moves them through the bloodstream. APOE polymorphic alleles are the major genetic factors for the risk of Alzheimer’s disease (AD).

19 Jul 2019

Adults with family history of Alzheimer’s have learning impairments, study finds

Adults with a first-degree relative with Alzheimer's disease perform more poorly on online paired-learning tasks than adults without such a family history, and this impairment appears to be exacerbated by having diabetes or a genetic variation in the apolipoprotein E (APOE) gene linked to the disease.

10 Jul 2019

Study uncovers new way to identify driver genes important for cancer progression

Until now, researchers believed recurrent mutations (hotspot mutations) in cancer tumors were the important mutations (driver mutations) that promoted cancer progression.

29 Jun 2019

Scientists reveal insights into how a common Alzheimer's risk gene disrupts brain cells

Insights into how a gene that increases the risk of Alzheimer's disease disrupts brain cells have been revealed by scientists.

27 Jun 2019

Apolipoproten E appears to be new potential druggable target for Alzheimer's

Apolipoproten E is a major genetic risk factor for the development of Alzheimer's disease, yet the protein tends to be understudied as a potential druggable target for the mind-robbing neurodegenerative disease.

13 Jun 2019

NIH funds clinical trials to assess applicability of genomics for treating chronic diseases

The National Institutes of Health will fund clinical trials to assess the benefits, applicability and efficacy of applying genomic medicine interventions to improve management of diseases such as high blood pressure, depression and chronic pain.

6 Jun 2019

Dietary cholesterol or egg consumption not linked with elevated risk of stroke

A new study from the University of Eastern Finland shows that a moderately high intake of dietary cholesterol or consumption of up to one egg per day is not associated with an elevated risk of stroke.

20 May 2019

Rare gene mutation may prevent heart disease, study reveals

Targeting apolipoprotein B gene has not been tested in clinical trials for cardiovascular outcomes because of risk of fatty liver disease, but naturally-occurring mutation suggests it may be effective.

13 May 2019

Scientists develop new video game that may help in the study of Alzheimer's

How do we find our way around? Why do I always get lost while my friend never does? Why does people's sense of direction vary so widely in general? Is it linked to inherent, genetic characteristics or determined by cultural factors?

25 Apr 2019

APOE gene impacts sleep depending on gender and severity of Alzheimer's

The gene most often associated with risk of Alzheimer's Disease impacts sleep depending on gender and the severity of Alzheimer's in a patient, suggests a study led by researchers at the Keenan Research Centre for Biomedical Science.

15 Apr 2019

Research opens door to development of drug or vaccine for late-onset Alzheimer's

UT Southwestern researchers have succeeded in neutralizing what they believe is a primary factor in late-onset Alzheimer's disease, opening the door to development of a drug that could be administered before age 40, and taken for life, to potentially prevent the disease in 50 to 80 percent of at-risk adults.

17 Dec 2018

Myriad biological, societal factors that impact CKD severity for children of African descent

Myriad biological and societal factors can impact the occurrence and accelerate progression of chronic kidney disease for children of African descent - including preterm birth, exposure to toxins during gestation and lower socioeconomic status - and can complicate these children's access to effective treatments, according to an invited commentary published in the November 2018 edition of American Journal of Kidney Diseases.

21 Nov 2018

New research project to combat obesity, type 2 diabetes receives NIH funding

A research project headed by a faculty member from the Ohio University Heritage College of Osteopathic Medicine, which will explore whether administering a protein that's produced in the body can help prevent obesity and type 2 diabetes, has received $464,145 in funding from the National Institutes of Health.

20 Nov 2018

Neuroene Therapeutics receives $1.5 million NIH grant to develop anti-seizure compound for epilepsy

Neuroene Therapeutics, a start-up company founded by mitochondrial biologist Sherine S. L. Chan, Ph.D. and medicinal chemist C. James Chou, Ph.D. of the Medical University of South Carolina, has received a $1.5 million NIH Phase II Small Business Innovation Research grant to optimize vitamin K analogues that could improve seizure control in patients with drug-resistant epilepsy.

29 Oct 2018

Could we prevent Alzheimer's disease by treating herpes?

An exciting new paper suggests that over half of all cases of Alzheimer’s disease could be traced back to herpes simplex virus 1, which causes cold sores.

19 Oct 2018

Carnegie scientist awarded NIH grant to identify novel medicines for cardiovascular disease

Carnegie's Department of Embryology scientist Steven Farber and team have been awarded a 5-year $3.3-million NIH grant to identify novel pharmaceuticals for combatting a host of diseases associated with altered levels of lipoproteins like LDL ("bad cholesterol").

11 Oct 2018