Oncogene News and Research

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An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell.

Researchers devise strategies to target glioma stem cells that could improve patient survival

Glioblastoma multiforme is the most common and aggressive primary brain tumor and has one of the worst survival rates of all cancers.

5 Feb 2018

Researchers use innovative method to screen kinases for cancer drug's effectiveness

In recent years, a powerful suite of drugs known as kinase inhibitors have been developed to treat cancer and other diseases. Primary targets of such drugs include a family of receptor tyrosine kinases (RTKs) which protrude from cell surfaces like antennae and can activate cancer-related pathways in virtually all types of cancer when signaling molecules bind with them.

5 Feb 2018

New study sheds light on important protein involved in memory formation

A team of researchers have made important discoveries about a protein called AKT that is key to the formation of new memories.

29 Jan 2018

Study sheds light on key protein involved in memory formation and brain growth

Ask a nonscientist what memories are made of and you'll likely conjure images of childhood birthday parties or wedding days. Charles Hoeffer thinks about proteins.

27 Jan 2018

Study finds specific protein that plays role in breast cancer metastasis

Researchers from the University of Liverpool have found an explanation for how breast cancer spreads to the lungs, which could potentially hold the key to preventing the progression of the disease.

25 Jan 2018

Metabolic shift can result in congestive heart failure

The heart derives its energy primarily from fatty acids. However, if a metabolic shift to other energy sources takes place, this can result in congestive heart failure, scientists from the German Cancer Research Center and Heidelberg University Hospital have now discovered.

23 Jan 2018

Novel nanomedicine prolongs survival of pancreatic tumor-bearing mice

A new Tel Aviv University study pinpoints the inverse correlation between a known oncogene -- a gene that promotes the development of cancer -- and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival.

2 Jan 2018

Research provides new understanding of how cancer cells move during metastasis

A University of Hawai'i Cancer Center researcher has identified how some cancer cells are made to move during metastasis. The research provides a better understanding of how cancer spreads and may create new opportunities for cancer drug development.

28 Dec 2017

Stem cells remain healthy following low-dose X-ray exposure, say biophysicists

Biophysicists have shown that following low-dose exposure to X-rays (at 80 milligrays), stem cells remain healthy, proliferate, and do not accumulate DNA damage to be passed on to their progeny. The paper was published in the journal Aging.

20 Dec 2017

Study provides insights into molecular mechanisms regulating cellular fate of SCCs

Researchers at Kanazawa University report in EMBO Reports, 7 December 2017, new molecular mechanisms regulating cellular fate of squamous cell carcinomas.

15 Dec 2017

St. Jude gene therapy offers hope for infants with 'bubble boy' disease

Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency disorder.

11 Dec 2017

Groundbreaking study identifies protein as potential factor in cancer metastasis

U of G scientists have made a discovery that could reduce the spread of cancer by hindering a protein that binds cancer cells together and allows them to invade tissues.

17 Nov 2017

Researchers develop computer program to find new indications for old drugs

Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs.

16 Nov 2017

Changes in multiple different genes drive world's most deadly forms of lung cancer

A new UC San Francisco–led study challenges the dogma in oncology that most cancers are caused by one dominant "driver" mutation that can be treated in isolation with a single targeted drug. Instead, the new research finds one of the world's most deadly forms of lung cancer is driven by changes in multiple different genes, which appear to work together to drive cancer progression and to allow tumors to evade targeted therapy.

15 Nov 2017

CHOP researchers discover key differences among gene fusions in childhood brain tumors

Researchers investigating pediatric low-grade gliomas, the most common type of brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer.

17 Oct 2017

Scientists discover new non-genetic cause of resistance to anti-cancer therapies

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States.

16 Oct 2017

Researchers discover mutation that amplifies capabilities of tumor-suppressor protein

Cancer researchers have long hailed p53, a tumor-suppressor protein, for its ability to keep unruly cells from forming tumors. But for such a highly studied protein, p53 has hidden its tactics well.

9 Oct 2017

Study provides insights into non-oncogenic addictions of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding stromal tissue.

9 Oct 2017

Researchers identify new cancer-causing pathway behind most aggressive type of leukemia

A team led by Massachusetts General Hospital (MGH) investigators has identified a new cancer-causing pathway behind most cases of an aggressive type of leukemia, findings that could lead to new targeted treatment approaches.

3 Oct 2017

Research findings can lead to new treatment for patients with fatal glandular cancer

A new combination of existing drugs has been shown to block the cancer gene behind a fatal form of glandular cancer, adenoid cystic carcinoma. The findings from the Sahlgrenska Academy can lead to new treatment for patients with this disease relatively soon.

28 Sep 2017