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Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

12 Nov 2025

Researchers identify a protein vital to endothelial wound healing after surgery

Surgeons in the United States perform nearly 600,000 coronary artery stent procedures and bypass surgeries every year.

12 Nov 2025

LRIG1 could serve as important biomarker to distinguish between glioma types and grades

A new research paper was published in Oncotarget (Volume 16) on November 6, 2025, titled "LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas."

12 Nov 2025

What the air you breathe may be doing to your brain

For years, the two patients had come to the Penn Memory Center at the University of Pennsylvania, where doctors and researchers follow people with cognitive impairment as they age, as well as a group with normal cognition.

12 Nov 2025

Plant-based oat protein hybrid doubles iron absorption in women

Research on oat protein nanofibril-iron hybrids highlights their potential to significantly improve iron absorption, tackling global nutritional deficiencies.

12 Nov 2025

Stress-induced neuron loss shown to disrupt blood flow and neural communication

While the exact causes of neurodegenerative brain diseases like Alzheimer's and dementia are still largely unknown, researchers have been able to identify a key characteristic in affected brains: reduced blood flow.

11 Nov 2025

New insights into how endoplasmic reticulum and lysosomes coordinate protein production

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions between organelles are important for regulating cellular processes.

11 Nov 2025

Long non-coding RNA MALAT1 linked to progression and spread of triple-negative breast cancer

When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer's development or spread.

11 Nov 2025

Prior exposure to cold viruses boosts antibody response against SARS-CoV-2

Prior exposure to coronaviruses that cause ordinary colds can boost the immune system's ability to attack a vulnerable site on the COVID-19-causing coronavirus SARS-CoV-2, according to a study led by investigators at Weill Cornell Medicine.

11 Nov 2025

Amyloid-clearing drug fails to change waste clearance function in the brains of Alzheimer's patients

A group from Osaka Metropolitan University in Japan, led by graduate student Tatsushi Oura and Dr. Hiroyuki Tatekawa, found that treatment using the drug lecanemab to remove amyloid plaques in the brain does not change the waste clearance function in the brains of Alzheimer's disease (AD) patients in the short term.

11 Nov 2025

Nanoparticle vaccine eliminates HPV-induced tumors in animal model

A nanoparticle vaccine designed to fight cancers induced by human papillomavirus (HPV) eradicated tumors in an animal model of late-stage metastatic disease, UT Southwestern Medical Center scientists report in a new study published in the Proceedings of the National Academy of Sciences (PNAS).

11 Nov 2025

Mapping London’s food deserts and nutrition gaps

A study reveals London's food deserts, linking access to healthy food with income, culture, and transportation, highlighting urgent public health challenges.

11 Nov 2025

Targeting RNA splicing errors protects against tau-induced neurodegeneration

Alzheimer's Disease (AD), the leading cause of dementia, affects nearly 40 million individuals globally, resulting in a gradual loss of memory and independence. Despite extensive research over the past decades, no treatments have been found that can halt or reverse the progression of this devastating disease.

11 Nov 2025

New data supports earlier use of evolocumab in high-risk diabetes

Adding the PCSK9 inhibitor evolocumab to a high-intensity, cholesterol-lowering regimen reduced the risk of a first major cardiovascular event among adults with atherosclerotic cardiovascular disease (ASCVD) or diabetes , according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

11 Nov 2025

Study uncovers new mechanism for chromosome congression during mitosis

A research team from The University of Osaka, in collaboration with the Massachusetts Institute of Technology, has uncovered a new molecular mechanism underlying chromosome alignment during cell division. The study demonstrates that two motor proteins, KIF18A and CENP-E, act cooperatively to ensure proper chromosome congression. Remarkably, simultaneous inhibition of these proteins selectively kills cancer cells, suggesting a promising therapeutic avenue.

10 Nov 2025

Scientists pinpoint a reason Alzheimer’s patients forget loved ones

One of the most devastating moments for family members of a patient with Alzheimer's is when their loved one forgets who they are. New University of Virginia School of Medicine research may explain why that happens and could lead to a way to prevent it.

10 Nov 2025

Healthy meal deliveries boost quality of life for people with heart failure

Providing healthy, medically tailored meals or boxes of fresh produce along with nutrition counseling with a dietitian led to improved quality of life for people with heart failure compared to people who received dietary counseling without healthy food deliveries, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

10 Nov 2025

New drug combination gains Fast Track Designation for metastatic colorectal cancer

The U.S. Food and Drug Administration has granted Fast Track Designation to a new drug combination for metastatic colorectal cancer, following encouraging results from a clinical trial led in part by the University of Oklahoma Health Stephenson Cancer Center.

10 Nov 2025

Single daily polypill improves heart function and quality of life in heart failure patients

Adults with heart failure with reduced ejection fraction (HFrEF) who took a "polypill" combining medications prescribed for the treatment of heart failure, had improved heart function and symptoms, better quality of life, fewer hospitalizations and greater medication adherence than those taking the medications individually, according to a late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

10 Nov 2025

Blood protein pattern linked to increased risk of hereditary atherosclerosis

A specific pattern of proteins in the blood may reflect an increased risk of hereditary atherosclerosis. This is shown in a new study from Karolinska Institutet, examining close relatives of people who had suffered a heart attack at a young age.

10 Nov 2025