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Scientists develop in vitro stem cell-based bioassay for detecting biological activity of BoNTs

Scientists at the Institute for Infectious Diseases, University of Bern have developed an in vitro stem cell-based bioassay grown on multi-electrode arrays capable of detecting the biological activity of Clostridium botulinum neurotoxins.

28 Feb 2017

Researchers develop new assay for measuring underlying autoimmunity in rheumatoid arthritis patients

Current treatments for rheumatoid arthritis relieve the inflammation that leads to joint destruction, but the immunologic defect that triggers the inflammation persists to cause relapses, according to research conducted at NYU Langone Medical Center and the University of Pittsburgh.

24 Feb 2017

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

Investigators at the Medical University of South Carolina report pre-clinical research showing that a genetic variant encoded in neutrophil cystolic factor 1 (NCF1) is associated with increased risk for autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and Sjögren's syndrome, in the January 2017 issue of Nature Genetics.

8 Feb 2017

UCI researchers create unique VMT platform with potential for anti-cancer drug screening

Led by UCI professor of molecular biology & biochemistry Christopher C.W. Hughes, the research team successfully established multiple vascularized micro-organs on an industry-standard 96-well plate.

8 Feb 2017

Bacterial infection detector by Philips awarded prize for better use of antibiotics

Philips and Diagnostics Development win European Union ‘Horizon Prize – Better Use of Antibiotics’ for the rapid detection of bacterial infection on Philips’ Minicare I-20 platform.

8 Feb 2017

Next-generation sequencing assay shows accuracy, sensitivity in detecting genetic mutations in tumors

One of the most promising areas of cancer research is personalized therapy using precision medicine. The National Cancer Institute's NCI-MATCH is a large, ongoing clinical trial that matches tumors to therapies based on the tumor's genetic characteristics.

7 Feb 2017

Scientists evaluate rapid test that detects colistin resistance gene in bacterial isolates

Colistin is used as the "last-resort antibiotic" for dreaded multidrug-resistant pathogens, especially in hospitals. However, gut bacteria that have become insensitive to colistin now exist -- owing to the mobile resistance gene mcr-1. In early 2016, bacteria carrying this resistance gene were detected in Germany for the first time.

6 Feb 2017

Single Molecule Detection of Proteins in Single Cells

We developed this technology almost 10 years ago. It was developed after a key experiment was carried out by David Rissin, who was a PhD candidate in my laboratory at the time.

From Pittcon 3 Feb 2017

Nanion Technologies introduces new instrument for screening of membrane transporters and pumps

Nanion Technologies is pleased to announce the launch of the new SURFE2R 96SE Instrument for high throughput measurements of electrogenic membrane transporters and pumps.

From Nanion Technologies 3 Feb 2017

Illumina debuts new software to optimize data analysis for noninvasive prenatal testing

Illumina, Inc. today announced that it has declared conformity with the requirements of the IVD Directive and has applied the CE mark to an expanded VeriSeq NIPT Analysis Software for clinical laboratories in the European Union (EU).

From Illumina, Inc. 3 Feb 2017

Research unravels molecular mechanisms of antisense oligonucleotides

Stanley T. Crooke, MD, PhD, CEO of Ionis Pharmaceuticals and recipient of the 2016 Lifetime Achievement Award from the Oligonucleotide Therapeutic Society presents a detailed look at the mechanisms that underlie antisense drug activity in the article entitled "Molecular Mechanisms of Antisense Oligonucleotides," published in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers.

2 Feb 2017

Blood test that spots tumor DNA predicts survival of advanced breast cancer patients

Results of a multicenter study of 129 women with advanced breast cancer show that a blood test that spots cancer-linked DNA correctly predicted that most of those patients with higher levels of the tumor markers died significantly earlier than those with lower levels.

2 Feb 2017

Scientists synthesize and evaluate mono/di-halogenated coumarins for anticancer activity

Throughout the world, many medicinal compounds are being discovered. Scientists have learnt to modify the chemical structures of active compounds so that they can improved therapeutic activity and reduced the toxicity.

30 Jan 2017

Chromatrap® kit shown to excel in DNA purification

Chromatrap® reports on the excellent results achieved by customers using their 96 well high throughput plates for ultra-pure DNA purification.

From Chromatrap® - Porvair Sciences Ltd 26 Jan 2017

UAB researchers discover novel underlying mechanism involved in anxiety disorders, PTSD

University of Alabama at Birmingham neurobiologist Lynn Dobrunz, Ph.D., has discovered a novel mechanism for how stress-induced anxiety — the type of experience that can produce post-traumatic stress disorder, or PTSD — affects circuit function in the hippocampus, the area of the brain where aversive memories are formed.

24 Jan 2017

Siemens Healthineers introduces new CE-marked immunoassay for detecting Zika virus

Siemens Healthineers announced today its CE-marked immunoassay—the NovagnostZika Virus IgM µ-capture Assay—is now commercially available to laboratories outside of the U.S.

24 Jan 2017

Characterizing the Brain - Cell by Cell

My group develops approaches to study cell-to-cell signaling in the brain – how the cells of the brain talk to each other. The brain is heterogeneous, probably more so than any other organ in our body, and many of its functions depend on the unique characteristics of these cells.

From Pittcon 23 Jan 2017

BMG LABTECH announces integration of entire product range with Genedata Screener

BMG LABTECH collaborates with Genedatato provide a functionally rich integration between BMG LABTCH’s entire product range of dedicated and multi-mode microplate readers and Genedata Screener, a data analysis and management platform for in-vitro screening technologies.

From BMG LABTECH GmbH 20 Jan 2017

UCF researcher combines new and old science to create method for speedy medical tests

A UCF researcher has combined cutting-edge nanoscience with a magnetic phenomenon discovered more than 170 years ago to create a method for speedy medical tests.

20 Jan 2017

Service to screen for DNA damaging compounds released by Merck

Merck, a leading science and technology company, has introduced CAN MultiFlow™ screening services to more accurately predict genotoxic and mode of action* properties of substances, ingredients and drug compounds. Offered through its BioReliance® testing facilities, Merck will be the first company to provide this service in the United States.

20 Jan 2017

Assay News and Research

Scientists develop in vitro stem cell-based bioassay for detecting biological activity of BoNTs

Researchers develop new assay for measuring underlying autoimmunity in rheumatoid arthritis patients

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

UCI researchers create unique VMT platform with potential for anti-cancer drug screening

Bacterial infection detector by Philips awarded prize for better use of antibiotics

Next-generation sequencing assay shows accuracy, sensitivity in detecting genetic mutations in tumors

Scientists evaluate rapid test that detects colistin resistance gene in bacterial isolates

Single Molecule Detection of Proteins in Single Cells

Nanion Technologies introduces new instrument for screening of membrane transporters and pumps

Illumina debuts new software to optimize data analysis for noninvasive prenatal testing

Research unravels molecular mechanisms of antisense oligonucleotides

Blood test that spots tumor DNA predicts survival of advanced breast cancer patients

Scientists synthesize and evaluate mono/di-halogenated coumarins for anticancer activity

Chromatrap® kit shown to excel in DNA purification

UAB researchers discover novel underlying mechanism involved in anxiety disorders, PTSD

Siemens Healthineers introduces new CE-marked immunoassay for detecting Zika virus

Characterizing the Brain - Cell by Cell

BMG LABTECH announces integration of entire product range with Genedata Screener

UCF researcher combines new and old science to create method for speedy medical tests

Service to screen for DNA damaging compounds released by Merck

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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