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Exploring mouse models for studying liver fibrosis regression

Liver fibrosis is a progressive and potentially reversible condition that results from chronic liver damage, which can be caused by a variety of factors, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol abuse, and viral hepatitis.

8 Nov 2024

Key kinase involved in cell division linked to abnormal blood vessel growth in genetic disorder

Inhibition of CDK6 may prevent arteriovenous malformations in hereditary hemorrhagic telangiectasia by regulating endothelial cell cycle progression.

8 Nov 2024

New research unravels mitochondria's role in breast cancer metastasis

Mitochondria have long been known as the tiny organelles that act as the battery packs inside our cells while also serving as internal sensors and communicators.

7 Nov 2024

Seasonal influenza adapted and evolved during the COVID-19 pandemic

Although travel restrictions and social measures during the COVID-19 pandemic led to a dramatic global drop in seasonal influenza cases, certain influenza lineages in specific regions kept the virus circulating and evolving, according to a new study.

7 Nov 2024

Study reveals how COVID-19 affected the spread and evolution of seasonal influenza

Seasonal influenza epidemics impose substantial burdens on healthcare systems and cause >5 million hospitalizations of adults each year.

7 Nov 2024

UAB team develops a combined score to predict cancer treatment success

In 1937, President Franklin Roosevelt signed the National Cancer Act, launching a nationwide effort to combat the disease.

7 Nov 2024

Changes in gut microbiome could signal onset of rheumatoid arthritis

Changes in the make-up of the gut microbiome are linked to the onset of clinically evident rheumatoid arthritis in those at risk of the disease because of genetic, environmental, or immunological factors, suggests research published online in the Annals of the Rheumatic Diseases.

7 Nov 2024

CRISPR technology reveals essential noncoding RNAs in the human genome

Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins.

7 Nov 2024

New NCCN guidelines include expanded genetic risk assessment for various cancers

The National Comprehensive Cancer Network (NCCN) - an alliance of leading cancer centers focusing on maintaining evidence-based expert consensus driven guidelines for care - announces the publication of the expanded NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate.

7 Nov 2024

Researchers find 41 new genetic regions linked to disc herniations

Lumbar disc herniation is one of the most common structural changes in the lower back and the most common cause of radiating pain, or sciatica, in the leg.

7 Nov 2024

Aptamer extends agreement with genetic medicines customer

Aptamer's Optimer technology achieves key milestones in genetic medicine delivery, enhancing targeting specificity and advancing towards preclinical studies.

From Aptamer Group 7 Nov 2024

Anti-inflammatory cytokine linked to capillary obstruction and cognitive decline in diabetes

Elevated IL-10 in diabetes causes capillary obstruction, linked to cognitive deficits. Blocking IL-10 receptors shows promise for improving brain function.

7 Nov 2024

Emerging therapies transform autoimmune hepatitis treatment approaches

Autoimmune hepatitis (AIH) is a chronic, progressive liver disease caused by immune system dysregulation that targets the liver. If untreated, AIH can lead to severe complications, including cirrhosis and liver failure.

6 Nov 2024

Healthy lifestyle choices can offset genetic risk for brain diseases

Christopher D. Anderson, MD, MSc, chief of the Division of Stroke and Cerebrovascular Diseases at Brigham and Women's Hospital and associate neurologist in the Department of Neurology and Center for Genomic Medicine at Massachusetts General Hospital, is the corresponding author and Jonathan Rosand, MD, MSc, co-founder of the McCance Center for Brain Health and neurologist in the Department of Neurology and Center for Genomic Medicine at Massachusetts General Hospital, is an author of a paper published on November 6, 2024, in Neurology, the medical journal of the American Academy of Neurology, "Health-related behaviors and risk of common age-related brain diseases across severities of genetic risk."

6 Nov 2024

Understanding the role of neuroimmune cells in brain health and disease

The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system.

6 Nov 2024

Review: The multifaceted roles of bilirubin in liver health and disease

Bilirubin, the byproduct of hemoprotein breakdown, particularly hemoglobin, is a critical marker in diagnosing, prognosing, and managing liver diseases.

6 Nov 2024

Research sheds light on how fecal transplants improve gut health

In a novel study that identified male chromosome genetic material in the intestines of female patients undergoing fecal transplants, researchers at Johns Hopkins Medicine say they have significantly expanded scientific understanding of how some of these transplants may succeed and work.

6 Nov 2024

Stanford researchers unveil the key role of extrachromosomal DNA in cancer

A trio of research papers from Stanford Medicine researchers and their international collaborators transforms scientists' understanding of how small DNA circles - until recently dismissed as inconsequential - are major drivers of many types of human cancers.

6 Nov 2024

New study reveals how tumor cells evade the immune system

It is comparatively easy to tell a cell's state of health: On their surface, cells present fragments of almost all the proteins they contain inside.

6 Nov 2024

Multitarget stool DNA test shows promise for early colorectal cancer detection

A recent prospective cross-sectional study in Thailand demonstrates that multitarget stool DNA testing is highly sensitive and specific for detecting colorectal cancer (CRC) among Thai individuals.

6 Nov 2024