Preclinical News and Research

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Iridium attached to albumin can attack cancer cells when blasted with light

A new compound based on Iridium, a rare metal which landed in the Gulf of Mexico 66 M years ago, hooked onto albumin, a protein in blood, can attack the nucleus of cancerous cells when switched on by light, University of Warwick researchers have found.

4 Feb 2019

A new approach towards future treatment of diabetes

It is said that the eyes are the window to the soul, but they may also open the door for discovering new ways to achieve immune tolerance to transplanted islets in type 1 diabetes, according to research from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine.

3 Feb 2019

SCYNEXIS announces positive results from first interim efficacy analysis of FURI study

SCYNEXIS, Inc., a biotechnology company delivering innovative therapies for difficult-to-treat and often life-threatening infections, today announced positive results from the first interim efficacy analysis of the ongoing FURI study.

1 Feb 2019

Researchers identify regulatory mechanism underlying obesity

Obesity − as research in the past decade has shown − is first and foremost a brain disease. Researchers at Helmholtz Zentrum München, partners in the German Center for Diabetes Research, have now discovered a molecular switch that controls the function of satiety neurons and therefore body weight. The findings were published in the journal 'Nature Metabolism'.

31 Jan 2019

Researchers identify new therapeutic targets for kidney fibrosis

Chronic kidney disease is a global health concern, affecting about 10 percent of the world's population--and increasing in prevalence. A final, common pathway in chronic kidney disease is fibrosis.

29 Jan 2019

New drug compounds show promise in treating acute myeloid leukemia

Researchers have been struggling for years to find a treatment for patients who have a recurrence of acute myeloid leukemia (AML), an aggressive blood cancer that is one of the most lethal cancers. About 19,520 news cases are diagnosed a year, and about 10,670 people a year die from it, according to the American Cancer Society.

29 Jan 2019

Researchers discover immune regulator that appears to dictate glioblastoma

Researchers at The University of Texas MD Anderson Cancer Center have discovered an immune regulator that appears to dictate glioblastoma progression by shutting down immune surveillance, indicating a potential new area of therapeutic investigation.

28 Jan 2019

Targeting Sirt-1 enzyme shows promise in controlling graft-vs-host disease

Bone marrow transplant offers patients with leukemia and lymphoma a potentially curative treatment. Bone marrow from the donor contains healthy immune cells, whose mission is to protect the body from invaders.

28 Jan 2019

Scientists pinpoint mechanism that leads to steroid diabetes

Patients undergoing long-term treatment with steroids may suffer from metabolic side effects. Researchers at the Helmholtz Zentrum München and the Ludwig Maximilians University of Munich, partners in the German Center for Diabetes Research, have now pinpointed a mechanism that leads to so-called steroid diabetes

25 Jan 2019

Gero to present latest results of aging studies at Longevity Therapeutics Conference

Gero is a data-driven longevity company developing innovative therapies that will strongly extend the healthy period of life also known as healthspan. Latest results of Gero aging studies will be presented at Longevity Therapeutics Conference in San Francisco, January 29-31, 2019.

25 Jan 2019

Columbia researchers develop 'Cascade of Care' model to reduce opioid overdose and death

Drug overdose is now the leading cause of death for individuals under the age of 50, as the opioid epidemic continues unabated. One reason is that the majority of the estimated 2.4 million Americans with opioid use disorder aren't getting evidence-based treatment, including medications to treat opioid addiction.

24 Jan 2019

Researchers demonstrate strong evidence connecting bacterial pathogen and Alzheimer's pathogenesisis

New science uncovers how an unlikely culprit, Porphyromonas gingivalis (Pg) - the bacterium commonly associated with chronic gum disease - appears to drive Alzheimer's disease (AD) pathology.

24 Jan 2019

Nicotinamide riboside supplementation confers significant physiological benefits to mothers and offspring

ChromaDex Corp. today reported that results of a first-of-a-kind preclinical study on lactation have shown that supplementation with the unique B3 vitamin nicotinamide riboside confers significant and enduring physiological benefits to mothers and offspring.

23 Jan 2019

Lab-Scale Clarification of Mammalian Cell Cultures Expressing Recombinant Antibodies

Tina Stoschek and Marcus Gerlach discuss maximizing mAb generation using lab-scale clarification of cell cultures expressing recombinant antibodies.

From Sartorius 23 Jan 2019

Ludwig researchers find ways to make resistant melanomas susceptible to immunotherapy

A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies.

23 Jan 2019

Aspirin may reduce stroke risk in preeclamptic women

Middle-aged women with a history of preeclampsia have a greater risk of stroke, and aspirin may be able to reduce the risk, according to a new study led by researchers at Columbia University Vagelos College of Physicians & Surgeons.

23 Jan 2019

Skin samples hold early signs of prion disease, research suggests

Prions can infect both humans and animals, causing Creutzfeldt-Jakob disease in humans, mad cow disease in cattle, and chronic wasting disease in elk and deer. The infectious, misfolded protein particles often go undetected as they destroy brain tissue, causing memory loss, mobility issues, and ultimately death.

23 Jan 2019

TPU scientists develop new implants that double the rate of bone lengthening in kids

The implants developed by TPU scientists passed preclinical trials In the Ilizarov Orthopedic Center. These implants form part of the Ilizarov system variation applied for lengthening and correcting the deformations of long tubular bones in children.

22 Jan 2019

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Using a new epigenetics-based approach, scientists have managed to reduce memory loss and improve cognitive function in a mouse model of Alzheimer’s disease.

22 Jan 2019

Experimental drug can positively modify key characteristic behavior in FXS patients

Researchers at MIND Institute at UC Davis and Rush University Medical Center have found that mavoglurant, an experimental drug known as a mGluR5 negative modulator, can positively modify a key characteristic behavior in individuals with fragile X syndrome.

22 Jan 2019

Preclinical News and Research

Iridium attached to albumin can attack cancer cells when blasted with light

A new approach towards future treatment of diabetes

SCYNEXIS announces positive results from first interim efficacy analysis of FURI study

Researchers identify regulatory mechanism underlying obesity

Researchers identify new therapeutic targets for kidney fibrosis

New drug compounds show promise in treating acute myeloid leukemia

Researchers discover immune regulator that appears to dictate glioblastoma

Targeting Sirt-1 enzyme shows promise in controlling graft-vs-host disease

Scientists pinpoint mechanism that leads to steroid diabetes

Gero to present latest results of aging studies at Longevity Therapeutics Conference

Columbia researchers develop 'Cascade of Care' model to reduce opioid overdose and death

Researchers demonstrate strong evidence connecting bacterial pathogen and Alzheimer's pathogenesisis

Nicotinamide riboside supplementation confers significant physiological benefits to mothers and offspring

Lab-Scale Clarification of Mammalian Cell Cultures Expressing Recombinant Antibodies

Ludwig researchers find ways to make resistant melanomas susceptible to immunotherapy

Aspirin may reduce stroke risk in preeclamptic women

Skin samples hold early signs of prion disease, research suggests

TPU scientists develop new implants that double the rate of bone lengthening in kids

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Experimental drug can positively modify key characteristic behavior in FXS patients

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