Genetic Engineering News and Research

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Researchers uncover delicate protein balance behind the immune system response

A team of researchers from the University of Pennsylvania School of Veterinary Medicine has identified the protein interactions involved in the immune system process that fights infection yet, in certain inflammatory diseases, runs amok and attacks friendly tissue.

10 Dec 2007

Chikungunya virus spreads to new vectors

Researchers at the University of Texas Medical Branch have discovered how a key protein switch allows Chikungunya Virus (CHIKV) to spread to new vectors.

10 Dec 2007

Implanting embryonic cardiac cells prevents arrhythmias

When researchers at Cornell, the University of Bonn and the University of Pittsburgh transplanted living embryonic heart cells into cardiac tissue of mice that had suffered heart attacks, the mice became resistant to cardiac arrhythmias, thereby avoiding one of the most dangerous and fatal consequences of heart attacks.

5 Dec 2007

MicroRNA switches off tumor protection

The microRNA miR-21 suppresses the production of tumor suppressor Pdcd4, which protects cells from cancer development.

29 Nov 2007

Research suggests new direction for ALS treatment

A research team from Wake Forest University School of Medicine is the first to show that injections of a protein normally found in human cells can increase lifespan and delay the onset of symptoms in mice with ALS (amyotrophic lateral sclerosis), or Lou Gehrig's disease.

27 Nov 2007

Discovery of key acute myeloid leukemia gene

A gene called N-Myc leads a double life in certain white blood cells, helping to trigger a cancer called acute myeloid leukemia (AML) under some conditions while triggering apoptosis, or cell suicide, under other conditions, according to results of a mouse study done by investigators at St. Jude Children's Research Hospital.

27 Nov 2007

Research shows how embryonic cells may regulate levels of retinoic acid

Human embryos that get too much or too little retinoic acid, a derivative of Vitamin A, can develop into babies with birth defects.

21 Nov 2007

Regulation of the retinoic acid gradient in zebrafish embryos

Human embryos that get too much or too little retinoic acid, a derivative of Vitamin A, can develop into babies with birth defects.

21 Nov 2007

Gene-based therapy successful in Parkinson's disease

Brain scans have revealed that the first gene-based therapy for Parkinson's disease was effective.

20 Nov 2007

Protein in mice known as RGS13 suppresses allergic reactions

A protein in mice known as RGS13 suppresses allergic reactions, including the severe, life-threatening allergic reaction known as anaphylaxis, according to scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

20 Nov 2007

New insight into how cystatin C may lower the risk for Alzheimer's disease

For unknown reasons a protein called amyloid beta aggregates into toxic plaques in the brain, killing neurons.

19 Nov 2007

Potential new targeted treatments for Lupus

New research provides clues about the causes of lupus symptoms and suggests specific new targeted treatment strategies, according to Nilamadham Mishra, M.D., from Wake Forest University Baptist Medical Center, in presentations this week at the American College of Rheumatology in Boston.

13 Nov 2007

Overexpression of neuroglobin reduces severity of Alzheimer's disease in mice

Mice genetically engineered to both overproduce the protein neuroglobin and to develop Alzheimer's disease (AD) had a much milder form of the disease when compared to mice engineered to have AD alone, researchers at the Buck Institute for Age Research have reported.

13 Nov 2007

Tiny fluorescent probes illuminate protein interactions in living cells

While fluorescence has long been used to tag biological molecules, a new technology developed at Yale allows researchers to use tiny fluorescent probes to rapidly detect and identify protein interactions within living cells while avoiding the biological disruption of existing methods, according to a report in Nature Chemical Biology.

13 Nov 2007

Could a new vaccine be the key to stopping Alzheimer's disease?

A new study from the Oklahoma Medical Research Foundation (OMRF) shows that immunization could offer a way to blunt or even prevent the deadly, memory-robbing disease.

13 Nov 2007

Carnegie Mellon researchers to develop new stem cell-based drug delivery therapy

Carnegie Mellon University's Stefan F. Zappe is using adult neural stem cells to develop a new stem cell-based drug delivery therapy that may ultimately help treat a variety of inherited genetic disorders like Hunter syndrome.

5 Nov 2007

Immune cell age plays role in retinal damage in age-related macular degeneration

Studying a mouse model of age-related macular degeneration, the leading cause of blindness in older Americans, scientists at Washington University School of Medicine in St. Louis have found age is key in determining whether damaging blood vessels will form beneath the retina and contribute to vision loss.

2 Nov 2007

Case Western Reserve researchers breed a "Lance Armstrong" mouse

Case Western Reserve University researchers have bred a line of "mighty mice" (PEPCK-Cmus mice) that have the capability of running five to six kilometers at a speed of 20 meters per minute on a treadmill for up to six hours before stopping.

2 Nov 2007

Neural stem cells may help to restore memory after brain damage

In the study, mice with brain injuries experienced enhanced memory -- similar to the level found in healthy mice -- up to three months after receiving a stem cell treatment. Scientists believe the stem cells secreted proteins called neurotrophins that protected vulnerable cells from death and rescued memory.

31 Oct 2007

Scientists unveil structure of molecular target of many drugs

More than 40 years after beta blockers were first used clinically, scientists can finally get a detailed, three-dimensional look at the drugs' molecular target - the beta2-adrenergic receptor.

29 Oct 2007