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Researchers say genetics and life experience independently protect against cognitive decline in MS

U.S. and Italian researchers have determined that brain reserve, as well as cognitive reserve, independently protects against cognitive decline in multiple sclerosis (MS). Their article, "Brain reserve and cognitive reserve in multiple sclerosis: What you've got and how you use it", was published in Neurology on June 11, 2013.

26 Jun 2013

Karo Bio extends research collaboration with Pfizer on RORgamma modulators

Karo Bio AB announced today the extension of its existing research collaboration with Pfizer Inc. on RORgamma modulators to the end of 2014. Pfizer will continue to provide full funding for the research costs.

26 Jun 2013

Study shows absence of gene leads to early onset of more serious disease in MS animal model

Scientists led by a UCSF neurology researcher are reporting that they have identified the likely genetic mechanism that causes some patients with multiple sclerosis (MS) to quickly progress to a debilitating stage of the disease while other patients progress much more slowly.

25 Jun 2013

Research findings could lead to new potential treatment for multiple sclerosis

Myelin, the fatty coating that protects neurons in the brain and spinal cord, is destroyed in diseases such as multiple sclerosis. Researchers have been striving to determine whether oligodendrocytes, the cells that produce myelin, can be stimulated to make new myelin. Using live imaging in zebrafish to track oligodendrocytes in real time, researchers reporting in the June 24 issue of the Cell Press journal Developmental Cell discovered that individual oligodendrocytes coat neurons with myelin for only five hours after they are born. If the findings hold true in humans, they could lead to new treatment strategies for multiple sclerosis.

25 Jun 2013

Research: Stroke patients may be more likely to develop problems with memory and thinking

People who experience any stroke symptoms—but do not have a stroke—may also be more likely to develop problems with memory and thinking, according to new research published in the June 19, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.

20 Jun 2013

Penn researchers find ALS disease progresses in a stepwise, sequential pattern

The motor neuron disease Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, progresses in a stepwise, sequential pattern which can be classified into four distinct stages, report pathologists with the Perelman School of Medicine at the University of Pennsylvania in the Annals of Neurology.

20 Jun 2013

Research shows interaction of tau and amyloid-beta in brain may increase progression of AD

For years, Alzheimer's researchers have focused on two proteins that accumulate in the brains of people with Alzheimer's and may contribute to the disease: plaques made up of the protein amyloid-beta, and tangles of another protein, called tau.

20 Jun 2013

OHSU analysis finds previous studies have overstated effectiveness of bone growth product used in spinal surgeries

An analysis by the Evidence-based Practice Center at Oregon Health & Science University has found that previously published clinical trial studies about a controversial bone growth product used in spinal surgeries overstated the product's effectiveness.

19 Jun 2013

Blocking B1R receptor activity in brains of Alzheimer's mice recovers memory and cerebrovascular function

A new study shows that memory pathology in older mice with Alzheimer's disease can be reversed with treatment. The study by researchers from the Montreal Neurological Institute and Hospital - The Neuro, at McGill University and at Universit- de Montr-al found that blocking the activity of a specific receptor in the brain of mice with advanced Alzheimer's disease (AD) recovers memory and cerebrovascular function.

18 Jun 2013

Patients with central nervous system infections may suffer from the effects of CyCV-VN virus: Study

Patients in Vietnam and other locations with central nervous system infections may well be suffering from the effects of a newly discovered virus, according to a study to be published in mBio-, the online open-access journal of the American Society for Microbiology.

18 Jun 2013

New research finding raises questions about common mutant forms of JC polyomavirus

The JC polyomavirus is clearly opportunistic. It infects half the population but lethally destroys brain tissue only in immunocompromised patients - and it may be outright sneaky, too. Even as a new research paper allays fears that common mutant forms of the virus are the ones directly responsible for the disease's main attack, that same finding raises new questions about what the mutants are doing instead.

14 Jun 2013

Acrolein offers potential tool to reduce symptoms of spinal cord injuries and multiple sclerosis

A medical test previously developed to measure a toxin found in tobacco smokers has been adapted to measure the same toxin in people suffering from spinal cord injuries and multiple sclerosis, offering a potential tool to reduce symptoms.

14 Jun 2013

Kessler Foundation receives grants from NJ Commission to study deficits in TBI patients

The New Jersey Commission on Brain Injury Research awarded two grants to scientists at Kessler Foundation to study emotional processing deficits in people with traumatic brain injury (TBI) and the effects of aerobic exercise on memory impairments after TBI. The grants exceeded $500,000.

11 Jun 2013

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

A drug used to control Type II diabetes can help repair the spinal cords of mice suffering from the inherited disease adrenoleukodystrophy which, untreated, leads eventually to a paralysis, a vegetative state and death.

10 Jun 2013

New minimally invasive surgery for epilepsy offers quicker recuperation time for patients

A new minimally invasive laser-based tool for epilepsy surgery offers a quicker recuperation time for patients than major surgery, Mayo Clinic researchers report. The research is ongoing, but preliminary results were recently presented at the American Academy of Neurology.

6 Jun 2013

New approach in treating multiple sclerosis

In his article, "Pathoetiology of multiple sclerosis: are we barking up the wrong tree?", Peter K. Stys of the Hotchkiss Brain Institute, University of Calgary, argues that while the majority of the medical research community currently approaches MS as an autoimmune disease (much like Lupus and Rheumatoid Arthritis), for which the trigger is the immune system attacking a particular part of the nervous system, the features of the disease are equally well explained by approaching MS as a neurodegenerative disease (such as Parkinson's and Alzheimer's), which is followed by an immune reaction to damage.

5 Jun 2013

New technique selectively represses unwanted immune reactions without disabling immune system

The human immune system is remarkably efficient, but sometimes its attack is misdirected, leading to allergies, autoimmune diseases and rejection of transplant organs and therapeutic drugs. Current immune suppressants have major drawbacks, but a team from The Scripps Research Institute (TSRI) has demonstrated a new technique that may lead to a better way to selectively repress unwanted immune reactions without disabling the immune system as a whole.

4 Jun 2013

Study examines link between IL-17F and treatment response to interferon beta-1b in multiple sclerosis patients

A study by Hans-Peter Hartung, M.D., of Heinrich-Heine-Universität, Düsseldoft, Germany, and colleagues examines the association between IL-17F and treatment response to interferon beta-1b among patients with relapsing-remitting multiple sclerosis.

4 Jun 2013

Researchers now one step closer to unlocking the nature of ALS

As the result of a major breakthrough by researchers at Northwestern University's School of Medicine, researchers studying amyotrophic lateral sclerosis, commonly known as Lou Gehrig's Disease, are now one step closer to unlocking the nature of ALS.

4 Jun 2013

BACH2 gene may play a central role in the development of allergic and autoimmune diseases

Scientists at the National Institutes of Health, and their colleagues, have discovered that a gene called BACH2 may play a central role in the development of diverse allergic and autoimmune diseases, such as multiple sclerosis, asthma, Crohn's disease, celiac disease, and type-1 diabetes.

4 Jun 2013

Sclerosis News and Research

Researchers say genetics and life experience independently protect against cognitive decline in MS

Karo Bio extends research collaboration with Pfizer on RORgamma modulators

Study shows absence of gene leads to early onset of more serious disease in MS animal model

Research findings could lead to new potential treatment for multiple sclerosis

Research: Stroke patients may be more likely to develop problems with memory and thinking

Penn researchers find ALS disease progresses in a stepwise, sequential pattern

Research shows interaction of tau and amyloid-beta in brain may increase progression of AD

OHSU analysis finds previous studies have overstated effectiveness of bone growth product used in spinal surgeries

Blocking B1R receptor activity in brains of Alzheimer's mice recovers memory and cerebrovascular function

Patients with central nervous system infections may suffer from the effects of CyCV-VN virus: Study

New research finding raises questions about common mutant forms of JC polyomavirus

Acrolein offers potential tool to reduce symptoms of spinal cord injuries and multiple sclerosis

Kessler Foundation receives grants from NJ Commission to study deficits in TBI patients

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

New minimally invasive surgery for epilepsy offers quicker recuperation time for patients

New approach in treating multiple sclerosis

New technique selectively represses unwanted immune reactions without disabling immune system

Study examines link between IL-17F and treatment response to interferon beta-1b in multiple sclerosis patients

Researchers now one step closer to unlocking the nature of ALS

BACH2 gene may play a central role in the development of allergic and autoimmune diseases

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