Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Targeted therapy appears to be more effective in preventing lung cancer recurrence

The targeted therapy gefitinib appears more effective in preventing recurrence after lung cancer surgery than the standard of care, chemotherapy.

18 May 2017

Sperm epigenetics and fertility

Epigenetics is a system of information that lies atop DNA to control which genes are accessible, active and inactive. Each cell in your body essentially has identical DNA, but they have different patterns of expression.

18 May 2017

Biomarkers in the teeth of orangutans provide new understanding of human breast-feeding evolution

Biomarkers in the teeth of wild orangutans indicate nursing patterns related to food fluctuations in their habitats, which can help guide understanding of breast-feeding evolution in humans, according to a study published today in Science Advances.

17 May 2017

TUM scientists develop new pH sensor that provides insights into tumor metabolism

Tumors, inflammation and circulatory disorders locally disturb the body's acid-base balance. These changes in pH value could be used for example to verify the success of cancer treatments.

12 May 2017

Researchers identify microRNA biomarker linked to incidence of atrial fibrillation

Researchers have identified a microRNA biomarker that demonstrates a strong association with the incidence of atrial fibrillation, the most common abnormal heart rhythm that affects more than 2.7 million Americans.

11 May 2017

Elevated levels of specific protein linked to increased risk of ischemic stroke among women

Women with elevated levels of a protein in their blood may be at a higher risk of ischemic stroke, according to a study published in the May 10, 2017, online issue of Neurology, the medical journal of the American Academy of Neurology.

11 May 2017

Yogurt intake may increase hip bone density, reduce risk of osteoporosis in older adults

The largest observational study to date of dairy intakes and bone and frailty measurements in older adults has found that increased yogurt consumption was associated with a higher hip bone density and a significantly reduced risk of osteoporosis in older women and men on the island of Ireland, after taking into account traditional risk factors.

10 May 2017

New study identifies sugar replacement sweetener as biomarker for weight gain

A new study has identified the sugar alcohol erythritol as a biomarker for increasing fat mass. In contrast to previous assumptions and research, erythritol can be metabolized by, and even produced in, the human body.

10 May 2017

Studies pave way for genome-targeted treatments in pancreatic cancer

University of Pittsburgh and UPMC researchers are paving the way for genome-targeted treatments in pancreatic cancer, an especially deadly form of cancer with few existing therapeutic options, according to a pair of recent studies.

9 May 2017

Study reveals role of good-guy protein in initiating and maintaining cancer

Under normal conditions, the CHD4 protein is one of the good guys: it stops cells from transcribing faulty DNA, thereby eliminating potential mutation. But in colon cancer and perhaps other kinds of cancer as well, it appears that this protein becomes a kind of double agent, working for the enemy.

9 May 2017

Retirement period may widen socio-economic inequalities in stress and health, study suggests

A new paper published in the Journal of Gerontology suggests that the period around retirement may widen socio-economic inequalities in stress and health.

5 May 2017

Experts find benefits of antipsychotic medications to be much greater than side effects

An international group of experts has concluded that, for patients with schizophrenia and related psychotic disorders, antipsychotic medications do not have negative long-term effects on patients' outcomes or the brain.

5 May 2017

Recurrence of HPV-negative HNSCC after radiation therapy linked to high tumor levels of PD-L1 protein

Recurrence of head and neck squamous cell carcinoma (HNSCC) negative for human papillomavirus (HPV) following radiation therapy was associated with high tumor levels of the protein PD-L1.

5 May 2017

Researchers identify biomarker that could predict disease severity in glaucoma patients

Glaucoma, a leading cause of blindness worldwide, most often is diagnosed during a routine eye exam. Over time, elevated pressure inside the eye damages the optic nerve, leading to vision loss. Unfortunately, there's no way to accurately predict which patients might lose vision most rapidly.

4 May 2017

New imaging techniques at Mayo Clinic reveal tumor firmness, adhesion before brain cancer surgery

It's not often that a fall saves someone's life. Helen Powell, 74, says that was the case for her. A computerized tomography scan that followed her fall revealed a cancerous brain tumor that led her to Mayo Clinic and surgery using first-in-the-world technology.

4 May 2017

Walking intervention may reestablish protective neuronal connections in older adults with MCI

Could the initiation of a simple walking exercise program help older adults to reverse declines in key brain regions? A new study led by University of Maryland School of Public Health researchers adds more information about how physical activity impacts brain physiology and offers hope that it may be possible to reestablish some protective neuronal connections.

3 May 2017

Specific genetic changes in the placenta of women may serve as biomarker to predict newborn health

UCLA scientists have discovered specific genetic changes in the placentas of women who gave birth to growth-restricted infants. These changes appear to sabotage the ability of the placenta to grow blood vessels and adequately nourish the fetus, interfering with the infant's growth in the womb.

3 May 2017

Invivoscribe receives FDA approval for the LeukoStrat CDx FLT3 mutation assay companion diagnostic test for the selection of patients for Rydapt

Invivoscribe® Technologies Inc., a global company with more than 20 years of experience providing clonality and biomarker test solutions for the fields of oncology, personalized molecular diagnostics® and personalized molecular medicine®, today announces the premarket approval of LeukoStrat® CDx FLT3 Mutation Assay.

3 May 2017

Noninvasive PET imaging may predict cancer patients’ immunotherapy response early

A noninvasive PET imaging method that measures granzyme B, a protein released by immune cells to kill cancer cells, was able to distinguish mouse and human tumors that responded to immune checkpoint inhibitors from those that did not respond early in the course of treatment.

1 May 2017

Glycated CD59 identified as novel biomarker for screening and diagnosis of gestational diabetes

Mellitus, LLC today reported the publication of results from a prospective, investigator-initiated study conducted at Brigham and Women's Hospital demonstrating the potential clinical utility of glycated CD59 (GCD59) as a novel biomarker for the screening and diagnosis of gestational diabetes mellitus.

28 Apr 2017

Biomarker News and Research

Further Reading

Targeted therapy appears to be more effective in preventing lung cancer recurrence

Sperm epigenetics and fertility

Biomarkers in the teeth of orangutans provide new understanding of human breast-feeding evolution

TUM scientists develop new pH sensor that provides insights into tumor metabolism

Researchers identify microRNA biomarker linked to incidence of atrial fibrillation

Elevated levels of specific protein linked to increased risk of ischemic stroke among women

Yogurt intake may increase hip bone density, reduce risk of osteoporosis in older adults

New study identifies sugar replacement sweetener as biomarker for weight gain

Studies pave way for genome-targeted treatments in pancreatic cancer

Study reveals role of good-guy protein in initiating and maintaining cancer

Retirement period may widen socio-economic inequalities in stress and health, study suggests

Experts find benefits of antipsychotic medications to be much greater than side effects

Recurrence of HPV-negative HNSCC after radiation therapy linked to high tumor levels of PD-L1 protein

Researchers identify biomarker that could predict disease severity in glaucoma patients

New imaging techniques at Mayo Clinic reveal tumor firmness, adhesion before brain cancer surgery

Walking intervention may reestablish protective neuronal connections in older adults with MCI

Specific genetic changes in the placenta of women may serve as biomarker to predict newborn health

Invivoscribe receives FDA approval for the LeukoStrat CDx FLT3 mutation assay companion diagnostic test for the selection of patients for Rydapt

Noninvasive PET imaging may predict cancer patients’ immunotherapy response early

Glycated CD59 identified as novel biomarker for screening and diagnosis of gestational diabetes

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