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Chemical cues turn embryonic stem cells into cerebellar neurons

Embryonic stem cells have shown a great deal of promise for alleviating heart disease and regenerating organs. But for some of the conditions for which people hold out the most hope - Alzheimer's and Parkinson's, for example - there's been little evidence to date that stem cells can work.

14 Mar 2007

Cannibalistic signals help mammalian embryos develop normally

A cannibalistic process called autophagy spurs dying embryonic stem cells to send "eat me" and "come get me" signals to have their corpses purged, a last gasp that paves the way for normal mammalian development, UT Southwestern Medical Center researchers have found.

8 Mar 2007

Genetically caused deafness may be reversible by compensating for a missing protein

Emory University researchers have found that in mice, increasing the amount of the protein connexin26 in the ear's cochlea compensates for an absence of another protein, connexin30.

26 Feb 2007

First embryonic stem cell research grants approved under California Proposition 71

The California Institute for Regenerative Medicine's Independent Citizens' Oversight Committee on Friday announced the approval of the first human embryonic stem cell research grants provided under Proposition 71, the San Francisco Chronicle reports.

22 Feb 2007

Newborns with respiratory distress should be evaluated for primary ciliary dyskinesia

Reviewing published reports, Ferkol and Margaret Leigh, M.D., professor of pediatrics at the University of North Carolina at Chapel Hill (UNC), found that neonatal respiratory distress was a common clinical symptom of PCD, a chronic airway disease that affects about 1 in 15,000 children.

20 Feb 2007

Regulator of cholesterol production identified

By first probing the way primitive yeast make cholesterol, a team of scientists has discovered a long-sought protein whose human counterpart controls cholesterol production and potentially drug metabolism.

20 Feb 2007

Epigenetics to shape stem cell future

Everyone hopes that one day stem cell-based regenerative medicine will help repair diseased tissue. Before then, it may be necessary to decipher the epigenetic signals that give stem cells their unique ability to self-renew and transform them into different cell types.

19 Feb 2007

Researchers discover how to fight iron disorders with a drug against hypertension

We all know that iron deficiencies are dangerous, but also too much iron is bad for our health. Our body stores excess iron in various tissues, where it can lead to organ failure and even death if not treated before irreversible damage has occurred.

12 Feb 2007

Changes in breast cancer management

Aggressive research currently underway brings hope of dramatic advances in breast cancer management, according to a new review.

12 Feb 2007

Single transcription factor GABP a major player in cell growth

When cells go about the business of dividing, they can get sidelined. Maybe there aren't enough nutrients. Maybe there aren't the right signals to resume multiplying. Either way, cells go quiet.

7 Feb 2007

Bright quantum dots help basic cancer biology studies

Though there is little doubt that nanoscale devices are going to play a critical role in improving cancer detection and treatment over the next five to ten years, nanoparticles are already having a major impact on the way that cancer biologists study the processes that go awry within malignant and metastatic cells.

5 Feb 2007

Gene produces springy protein keeping nerve cells flexible

If you bend a knee or an elbow, the nerves in your limbs stretch but do not break. A University of Utah study suggests why: A gene produces a springy protein that keeps nerve cells flexible. When the gene was disabled in tiny nematode worms, their nerve cells literally broke.

29 Jan 2007

Potential protection against failed back surgery syndrome

Texas researchers believe that they have discovered how to prevent many cases of the most common problem encountered by patients undergoing spine surgery: failed back surgery syndrome (FBSS).

29 Jan 2007

Single protein plays a major role in prion diseases

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

23 Jan 2007

Variations in SORL1 gene may factor in development of Alzheimer's disease

Variations in a gene known as SORL1 may be a factor in the development of late onset Alzheimer's disease, an international team of researchers has discovered. The genetic clue, which could lead to a better understanding of one cause of Alzheimer's, is reported in Nature Genetics online, and was supported in part by the National Institutes of Health (NIH).

14 Jan 2007

Uric acid holds potential for central nervous system damage

Uric acid is commonly associated with the excruciatingly painful joint disease known as gout, but it can also play a crucial role in the treatment of spinal cord injury and other central nervous system disorders, such as stroke, multiple sclerosis and Parkinson's disease, according to Rutgers' Bonnie Firestein.

3 Jan 2007

Mifepristone offers hope for breast cancer victims

A team of scientists have discovered some unexpected benefits with the abortion pill RU486 (Mifepristone).

4 Dec 2006

Scientists explain how transport proteins can move in cells without bumping into or sticking to anything

Scientists from the Max Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG) in Dresden, along with a colleague from the University of Florida in the United States, have been carrying out research into how transport proteins can move in cells without bumping into or sticking to anything.

24 Oct 2006

Scientists discover how brain turns on system designed to protect nerve cells from toxic "free radicals"

Scientists at Dana-Farber Cancer Institute report they have found how the brain turns on a system designed to protect its nerve cells from toxic "free radicals," a waste product of cell metabolism that has been implicated in some degenerative brain diseases, heart attacks, strokes, cancer, and aging.

20 Oct 2006

Blood clotting protein appears to also play a role in fertility

A protein known to play a role in blood clotting and other cell functions is also critical for proper sperm formation in mice, according to researchers from the University of North Carolina at Chapel Hill School of Medicine.

20 Oct 2006