Genetic Engineering News and Research

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Carnegie Mellon researchers to develop new stem cell-based drug delivery therapy

Carnegie Mellon University's Stefan F. Zappe is using adult neural stem cells to develop a new stem cell-based drug delivery therapy that may ultimately help treat a variety of inherited genetic disorders like Hunter syndrome.

5 Nov 2007

Immune cell age plays role in retinal damage in age-related macular degeneration

Studying a mouse model of age-related macular degeneration, the leading cause of blindness in older Americans, scientists at Washington University School of Medicine in St. Louis have found age is key in determining whether damaging blood vessels will form beneath the retina and contribute to vision loss.

2 Nov 2007

Case Western Reserve researchers breed a "Lance Armstrong" mouse

Case Western Reserve University researchers have bred a line of "mighty mice" (PEPCK-Cmus mice) that have the capability of running five to six kilometers at a speed of 20 meters per minute on a treadmill for up to six hours before stopping.

2 Nov 2007

Neural stem cells may help to restore memory after brain damage

In the study, mice with brain injuries experienced enhanced memory -- similar to the level found in healthy mice -- up to three months after receiving a stem cell treatment. Scientists believe the stem cells secreted proteins called neurotrophins that protected vulnerable cells from death and rescued memory.

31 Oct 2007

Scientists unveil structure of molecular target of many drugs

More than 40 years after beta blockers were first used clinically, scientists can finally get a detailed, three-dimensional look at the drugs' molecular target - the beta2-adrenergic receptor.

29 Oct 2007

Step towards vaccine to prevent Chlamydia

Genetically engineered mice may hold the key to helping scientists from Queensland University of Technology and Harvard hasten the development of a vaccine to protect adolescent girls against the most common sexually transmitted disease, Chlamydia.

29 Oct 2007

Whole parasite malaria vaccine to be manufactured for clinical trials

Sanaria Inc. and the PATH Malaria Vaccine Initiative has officially opened a one-of-a-kind clinical manufacturing facility to produce a vaccine that uses a weakened form of the malaria parasite to fight a disease that annually kills more than one million people, most of them African children.

29 Oct 2007

Hypertension drugs may prevent Alzheimer's Disease

New research is suggesting that some of the drugs commonly used to treat hypertension (high blood pressure) may offer another benefit.

28 Oct 2007

Emerging cancer therapies and novel targets

What are the cancer drugs of tomorrow and how will they be developed? At the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, researchers will present some answers to these and other pressing questions regarding emerging cancer therapeutics.

25 Oct 2007

Researchers discover important tool in understanding differentiation in human embryonic stem cells

Researchers at the University of Minnesota's Stem Cell Institute have described how an existing genetic tool can be used to study how human embryonic stem cells differentiate.

24 Oct 2007

Johns Hopkins details scientific breakthroughs in malaria prevention and treatment

"Breaking the Cycle" chronicles five years of scientific discovery conducted by researchers at the Johns Hopkins Malaria Research Institute (JHMRI).

24 Oct 2007

Australian researchers stelp closer to discovering the cause of epileptic seizures

Scientists still do not know what causes epileptic seizures, but researchers from Melbourne's Howard Florey Institute are one step closer to solving this puzzle with the help of their newly developed genetically modified epileptic mouse.

22 Oct 2007

New role discovered for cilia

Johns Hopkins researchers and colleagues have found a previously unrecognized role for tiny hair-like cell structures known as cilia: They help form our sense of touch.

22 Oct 2007

Implicit wins $16.3 million U.S. government contract to develop its clinical stage drug oglufanide disodium

Implicit Bioscience has announced that it has been awarded a US$16.34 million (AU$18.2million) contract payable over 37 months from the United States Defense Threat Reduction Agency (DTRA) to develop its clinical stage drug oglufanide disodium as a broad spectrum therapeutic for the treatment of a number of intracellularbacterial diseases.

22 Oct 2007

Bacteria use plant defence for genetic modification

Bacteria that cause tumours in plants modify plant genomes by skilfully exploiting the plants' first line of defence.

22 Oct 2007

Childhood epilepsy research offers new hope for seizure control

18 Oct 2007

Defects in Jhdm2a gene could be the cause for some cases of male infertility

Scientists at the University of North Carolina at Chapel Hill have identified a gene crucial to the final step of the formation of a functional sperm cell.

18 Oct 2007

How does the opioid system work?

The opioid system controls pain, reward and addictive behaviors. Opioids exert their pharmacological actions through three opioid receptors, mu, delta and kappa whose genes have been cloned (Oprm, Oprd1 and Oprk1, respectively).

15 Oct 2007

Bacteria reveal targets of immune responses quick and direct identification of antigens

The Epstein-Barr virus (EBV) is a widespread herpes virus that infects more than 90 per cent of the worldwide human population.

10 Oct 2007

Antibody repairs myelin in lab study of multiple sclerosis and related disorders

Mayo Clinic researchers have found that a human antibody administered in a single low dose in laboratory mouse models can repair myelin, the insulating covering of nerves that when damaged can lead to multiple sclerosis and other disorders of the central nervous system.

10 Oct 2007

Genetic Engineering News and Research

Carnegie Mellon researchers to develop new stem cell-based drug delivery therapy

Immune cell age plays role in retinal damage in age-related macular degeneration

Case Western Reserve researchers breed a "Lance Armstrong" mouse

Neural stem cells may help to restore memory after brain damage

Scientists unveil structure of molecular target of many drugs

Step towards vaccine to prevent Chlamydia

Whole parasite malaria vaccine to be manufactured for clinical trials

Hypertension drugs may prevent Alzheimer's Disease

Emerging cancer therapies and novel targets

Researchers discover important tool in understanding differentiation in human embryonic stem cells

Johns Hopkins details scientific breakthroughs in malaria prevention and treatment

Australian researchers stelp closer to discovering the cause of epileptic seizures

New role discovered for cilia

Implicit wins $16.3 million U.S. government contract to develop its clinical stage drug oglufanide disodium

Bacteria use plant defence for genetic modification

Childhood epilepsy research offers new hope for seizure control

Defects in Jhdm2a gene could be the cause for some cases of male infertility

How does the opioid system work?

Bacteria reveal targets of immune responses quick and direct identification of antigens

Antibody repairs myelin in lab study of multiple sclerosis and related disorders

eBook: Using iPSCs models for human disease research and drug discovery eBook

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