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Investigational drug for treatment of sickle cell disease shows early promise in clinical trials

An investigational drug for the treatment of sickle cell disease is showing early promise in clinical trials for impacting biomarkers of the disease in patients, reported UConn School of Medicine researchers at the European Hematology Association Congress in Amsterdam this week.

20 Jun 2019

Research findings lead to new clinical trial for people with myelofibrosis

Researchers at Huntsman Cancer Institute at the University of Utah (U of U) discovered in laboratory studies that an experimental drug called selinexor may block a crucial survival pathway exploited by myelofibrosis cells.

20 Jun 2019

Henry Ford Cancer Institute treats its first patient with CAR T-cell therapy

Henry Ford Cancer Institute has treated its first patient with CAR T-cell therapy, an approach that uses engineered cells from a patient's immune system to destroy cancer.

18 Jun 2019

Groundbreaking drug boosts growth rates in children with achondroplasia

A groundbreaking drug that helps regulate bone development has boosted growth rates in children with achondroplasia - the most common type of dwarfism - in a global trial led by Melbourne's Murdoch Children's Research Institute.

18 Jun 2019

$VITALE study: High-dose vitamin D effective in lowering fracture rates after kidney transplantation$

VITALE study: High-dose vitamin D effective in lowering fracture rates after kidney transplantation

Lead VITALE investigator Dr Marie Courbebaisse (Paris, France), commented, Our study shows that currently recommended doses of vitamin D are not sufficient to protect patients from the risk of fracture after kidney transplantation.

17 Jun 2019

Indigestion remedy improves survival in people with late-stage CKD

Defined as serum bicarbonate less than 22 mmol/L, metabolic acidosis is common in people with CKD stages 4-5 (eGFR < 30 ml/min/1.73 m2) and is directly related to worsening kidney function.

17 Jun 2019

Online shopping interventions could help customers make healthier choices

Altering the default order in which foods are shown on the screen, or offering substitutes lower in saturated fat could help customers make healthier choices when shopping for food online, according to a study published in the open access International Journal of Behavioral Nutrition and Physical Activity.

16 Jun 2019

Roswell Park physician leads effort to compile new multiple myeloma imaging guidelines

Just as newer drugs have significantly improved outcomes for patients with multiple myeloma in the past decade, newer imaging techniques are upgrading detection of the disease, leading to earlier treatment.

14 Jun 2019

Antibodies could cause arthritic pain

Antibodies that exist in the joints before the onset of rheumatoid arthritis can cause pain even in the absence of arthritis, researchers from Karolinska Institutet in Sweden report.

13 Jun 2019

Over a quarter of adults aged 50+ have vitamin D deficiency, study finds

Over a quarter of adults aged 50+ are deficient in vitamin D according to researchers from Trinity College Dublin who announced their findings today (Thursday, June 13th).

13 Jun 2019

More screening and new treatments needed for sickle cell disease

The promise of new treatments for sickle cell disease, a group of inherited red blood cell disorders, has never been so great, but it will only be realized if there is constant investment in health policies such as programs for screening newborns, especially in sub-Saharan Africa, where most cases occur.

13 Jun 2019

Transgenerational BPA exposure may contribute to autism, study finds

Transgenerational bisphenol A exposure may contribute to autism, according to a mouse study published in the Endocrine Society's journal Endocrinology.

12 Jun 2019

Vitamin D and estrogen can prevent heart disease, stroke, and diabetes in women

Vitamin D and estrogen have already shown well-documented results in improving bone health in women.

12 Jun 2019

Disparities in race, ethnicity, and status affect progress in cancer survival rates in youth

A new study in JNCI Cancer Spectrum finds that dramatic increases in cancer survival in adolescents and young adults are undermined by continuing disparities by race, ethnicity, and socioeconomic status.

12 Jun 2019

Researchers identify new sarcoma familial risk gene

A team of WA researchers has uncovered new genes that could play an important role in the development of sarcoma, a group of rare bone, muscle and connective tissue cancers.

12 Jun 2019

Biomarker correlates with prostate cancer aggressiveness and predicts metastasis to bone

Mortality due to prostate cancer is usually related to its likelihood to metastasize, especially to bone. Prognostic biomarkers are urgently needed to predict disease aggression so that appropriate treatment can be selected.

12 Jun 2019

Fibrinogen a key player in health and disease, says new study

A new study from the University of Alberta demonstrated that the blood clotting protein called fibrinogen also regulates MMP-2, an enzyme involved in immunity and in clot formation inside blood vessels. Prolonged MMP-2 inhibition could potentially produce a deficiency state with severe consequences.

12 Jun 2019

Electric scooters are leading to rising numbers of facial and head injuries

A Rutgers study has found that riding electric scooters have led to three times higher facial and head injuries over the last decade.

12 Jun 2019

Study finds potential treatment for patients with Complex Regional Pain Syndrome

A study, published today in PNAS, has found a potential treatment for patients with Complex Regional Pain Syndrome.

11 Jun 2019

Why your perception of ‘old’ changes as you age

My perception of old age is inextricably linked to my grandmother. When I was a kid, I thought this 65-year-old, white-haired woman whose entire body wobbled when she walked was very old. Now that I'm 66, my personal perception — or perhaps, misperception — of old age has changed. I suspect I've got lots of company.

11 Jun 2019