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Biologists reveal unusual structure of coronavirus protein linked to immune evasion

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Researchers identify a simple way to eliminate sequencing errors produced by portable DNA sequencer

Researchers have found a simple way to eliminate almost all sequencing errors produced by a widely used portable DNA sequencer, potentially enabling scientists working outside the lab to study and track microorganisms like the SARS-CoV-2 virus more efficiently.

13 Jan 2021

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

A new preprint that appeared on the bioRxiv server reports that intranasal vaccination with the D614G variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus monkeys reduces viral shedding. This is an experiment in non-human primates (NHP), and its extrapolation to humans is unclear as yet.

12 Jan 2021

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization.

12 Jan 2021

Clinicians at leading cardiac center report burnout and high levels of distress

More than half the clinicians surveyed at the Peter Munk Cardiac Centre reported burnout and high levels of distress according to a series of studies published today in the Canadian Medical Association Journal Open.

12 Jan 2021

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

12 Jan 2021

Master Regulator proteins control cancer transcriptional identity

Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer's origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer's transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.

11 Jan 2021

Researchers identify biomarkers in sperm for paternal offspring autism susceptibility

Biomarkers in human sperm have been identified that can indicate a propensity to father children with autism spectrum disorder.

11 Jan 2021

Large-scale genome sequencing shows how SARS-CoV-2 mutated

A new study published on the preprint server bioRxiv* describes the results of genomic sequencing of the virus, which may help trace the routes of transmission of the virus from person to person, and from country to country.

10 Jan 2021

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences

In a recent bioRxiv preprint study, researchers from the University of Hawaii showed that the S gene of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating according to the sequence and phylogenetic analysis.

10 Jan 2021

Modeling study sheds light on SARS-CoV-2 genome packaging

Researchers at the University of North Carolina at Chapel Hill have conducted a study exploring how the spatial patterning of certain genomic RNA regions in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes compaction, packaging, and cyclization of the viral genome.

10 Jan 2021

Using genomic analysis to map the introduction of SARS-CoV-2 virus in the UK

The SARS-CoV-2 virus was introduced to the United Kingdom well over 1,000 times in early 2020, according to researchers who analyzed more than 50,000 viral sequences from the first wave of the COVID-19 pandemic in the UK.

8 Jan 2021

International consortium awarded SNSF Sinergia grant to improve treatment for pediatric brain tumors

SNSF Sinergia grant awarded to research groups in Switzerland and Norway to identify novel treatment strategies for children with aggressive brain tumors.

7 Jan 2021

RNA sequencing data reveals three major molecular subtypes of Alzheimer's disease

Researchers at the Icahn School of Medicine at Mount Sinai have identified three major molecular subtypes of Alzheimer's disease (AD) using data from RNA sequencing.

7 Jan 2021

Researchers provide comprehensive molecular characterization of head and neck cancers

In what is believed to be the most comprehensive molecular characterization to date of the most common type of head and neck cancer, researchers from the Johns Hopkins departments of pathology and oncology, the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine, and 18 other centers around the U.S. and Poland have clarified the contribution of key cancer-associated genes, proteins and signaling pathways in these cancers, while proposing possible new treatment avenues.

7 Jan 2021

Which strain should SARS-CoV-2 vaccine candidates target?

A researcher at Clemson University, USA, has recently explored how governments might effectively combat the pandemic through strategic vaccination as new variants and strains of the virus emerge. The study suggests that vaccine candidates should target the fast-spreading variant, even when the initial prevalence is much lower.

7 Jan 2021

Covid-19 project receives government funding to expand globally

Supercomputing facilities set up to track the spread and evolution of the COVID-19 pandemic have received £1.2M in government funding to expand globally.

7 Jan 2021

More stringent measures may be needed to control new SARS-CoV-2 B.1.1.7 variant in England

Researchers in the UK have conducted a comprehensive epidemiologic analysis of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant in an effort to learn more about the expanded range and frequency of coronavirus disease 2019 (COVID-19) cases in England.

6 Jan 2021

Mount Sinai and Rumi Scientific join hands to initiate autism drug discovery pipeline

The Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai and Rumi Scientific announced today that they will team up to initiate a drug discovery pipeline for rare genetic disorders that carry a high risk of autism.

6 Jan 2021

Statins may protect the heart from damaging side-effects of early breast cancer treatment

New research from UHN's Peter Munk Cardiac Centre (PMCC) shows statins, commonly prescribed to lower cholesterol and reduce the risk of heart disease and stroke, may also protect the heart from damaging side-effects of early breast cancer treatment.

6 Jan 2021

Genomic News and Research

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

Researchers identify a simple way to eliminate sequencing errors produced by portable DNA sequencer

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

Clinicians at leading cardiac center report burnout and high levels of distress

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

Master Regulator proteins control cancer transcriptional identity

Researchers identify biomarkers in sperm for paternal offspring autism susceptibility

Large-scale genome sequencing shows how SARS-CoV-2 mutated

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences

Modeling study sheds light on SARS-CoV-2 genome packaging

Using genomic analysis to map the introduction of SARS-CoV-2 virus in the UK

International consortium awarded SNSF Sinergia grant to improve treatment for pediatric brain tumors

RNA sequencing data reveals three major molecular subtypes of Alzheimer's disease

Researchers provide comprehensive molecular characterization of head and neck cancers

Which strain should SARS-CoV-2 vaccine candidates target?

Covid-19 project receives government funding to expand globally

More stringent measures may be needed to control new SARS-CoV-2 B.1.1.7 variant in England

Mount Sinai and Rumi Scientific join hands to initiate autism drug discovery pipeline

Statins may protect the heart from damaging side-effects of early breast cancer treatment

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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