Clinical Trial News and Research

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Gut microbiome likely to contribute to HIV infection

New UCLA-led research suggests certain gut bacteria -- including one that is essential for a healthy gut microbiome – differ between people who go on to acquire HIV infection compared to those who have not become infected.

30 Sep 2022

Alzheimer’s researchers highlight the need for inclusive clinical trials

Enrolling representative populations in clinical trials for Alzheimer's disease is critical for finding treatments that will be safe and effective for all patients. African Americans and Latinos are disproportionately affected by this disease yet are substantially underrepresented in trials of promising therapies. For example, an analysis of data from more than 100 clinical trials testing new treatments for Alzheimer's disease found that only 12% of participants were of any non-White race or Hispanic ethnicity.

30 Sep 2022

KHN’s ‘What the Health?’: On government spending, Congress decides not to decide

Congress is supposed to complete its annual appropriations bills before the start of the fiscal year on Oct. 1.

29 Sep 2022

Mouse model reveals link between GABA receptors and sleepiness in people with myotonic dystrophy

People with the inherited disorder myotonic dystrophy (DM) often experience excessive daytime sleepiness and fatigue, as well as altered responses to anesthetics that can put them at risk for complications when hospitalized.

29 Sep 2022

CAR T-cell therapy produces impressive results in first clinical trial in patients with multiple myeloma

A therapy made of immune system T cells engineered to target a somewhat enigmatic cell protein called GPRC5D antigen produced impressive results in its first clinical trial in patients with multiple myeloma, researchers at Memorial Sloan Kettering Cancer Center (MSK), Dana-Farber Cancer Institute and Roswell Park Comprehensive Cancer Center report in a new study published today by the New England Journal of Medicine.

29 Sep 2022

Bionic pancreas more effective at maintaining blood glucose levels in people with type 1 diabetes

A device known as a bionic pancreas, which uses next-generation technology to automatically deliver insulin, was more effective at maintaining blood glucose (sugar) levels within normal range than standard-of-care management among people with type 1 diabetes, a new multicenter clinical trial has found.

28 Sep 2022

Vitamin supplements can benefit cystic fibrosis patients, study suggests

Cystic fibrosis patients who supplement their diet with vitamin C can also derive greater benefit from another antioxidant, vitamin E, resulting in a reduction in damaging inflammation, a study led by Oregon State University suggests.

28 Sep 2022

Study finds dimethyl fumarate was not associated with an improvement in clinical outcomes in adults hospitalized with COVID-19

Researchers evaluated the efficacy of the anti-inflammatory drug dimethyl fumarate in treating COVID-19 as part of an early phase, randomized, controlled assessment trial in the UK.

28 Sep 2022

One-time test predicts which hospitalized COVID-19 patients are likely to worsen, study finds

A one-time test could predict which people hospitalized with COVID-19 are likely to worsen significantly during their stay, even if they were admitted with relatively mild symptoms, according to a study of more than 2,500 people headed by researchers at Stanford Medicine.

27 Sep 2022

Giving immunotherapy before targeted therapy improves survival in patients with advanced melanoma

A clinical trial led by clinicians at Georgetown Lombardi Comprehensive Cancer Center showed a remarkable 20 percent advantage in the two-year overall survival rate for people with advanced melanoma who first received immunotherapy (72 percent survival rate) versus those who initially got targeted therapies (52 percent survival rate).

27 Sep 2022

Cycles of fasting-mimicking diet appear to reduce signs of Alzheimer’s in mice

Cycles of a diet that mimics fasting appear to reduce signs of Alzheimer's in mice genetically engineered to develop the illness, according to a new USC Leonard Davis School of Gerontology-led study.

27 Sep 2022

What is the impact of SARS-CoV-2 infection on semen parameters and sex hormones?

A new study aimed to systematically review studies investigating sex hormones and semen parameters in COVID-19 patients to provide a better understanding and treatment approach.

27 Sep 2022

New approach provides better understanding of atherosclerosis in the leg arteries

Cardiovascular experts at UVA Health have found a new way to track peripheral artery disease (PAD), a serious medical condition involving atherosclerosis in the leg arteries that affects more than 200 million people worldwide.

26 Sep 2022

Study shows the importance of night-time blood pressure assessment for diagnosing hypertension

Around 15% of people aged 40-75 may have a form of undiagnosed high blood pressure (hypertension) that occurs only at night-time.

26 Sep 2022

Clinical suite to help unlock the mysteries of neurological disorders

A clinical suite at a University of Queensland health research facility is ready to help unlock the mysteries of neurological conditions experienced by one billion people worldwide.

26 Sep 2022

Blueberries, a tasty intervention against age-related cognitive decline

In a recent study published in the Nutritional Neuroscience journal, researchers assessed the impact of consumption of wild blueberries on the speed of processing in mild cognitive decline.

25 Sep 2022

Investigating a potential new treatment for glioblastomas

A research question posed in Pankaj Desai's lab has led to a decade of research, a clinical trial and major national funding to further investigate a potential new treatment for the most deadly form of brain tumors.

23 Sep 2022

Cleveland Clinic’s ROBIN center may pave way for more effective radiation, immunotherapy treatments

Cleveland Clinic received a $7.9 million five-year grant from the National Cancer Institute at the National Institutes of Health to form one of three national centers as part of the newly established Radiation Oncology-Biology Integration Network (ROBIN).

22 Sep 2022

Anti-fibrotics found to be safe, effective for interstitial lung disease in patients with rheumatoid arthritis

For the first time, researchers have shown that a class of anti-fibrotic drugs slows the progression of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA).

22 Sep 2022

Can a commercial breath analysis test detect SARS-CoV-2?

Researchers demonstrated the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by a commercial breath analysis test (BAT).

22 Sep 2022

Clinical Trial News and Research

Gut microbiome likely to contribute to HIV infection

Alzheimer’s researchers highlight the need for inclusive clinical trials

KHN’s ‘What the Health?’: On government spending, Congress decides not to decide

Mouse model reveals link between GABA receptors and sleepiness in people with myotonic dystrophy

CAR T-cell therapy produces impressive results in first clinical trial in patients with multiple myeloma

Bionic pancreas more effective at maintaining blood glucose levels in people with type 1 diabetes

Vitamin supplements can benefit cystic fibrosis patients, study suggests

Study finds dimethyl fumarate was not associated with an improvement in clinical outcomes in adults hospitalized with COVID-19

One-time test predicts which hospitalized COVID-19 patients are likely to worsen, study finds

Giving immunotherapy before targeted therapy improves survival in patients with advanced melanoma

Cycles of fasting-mimicking diet appear to reduce signs of Alzheimer’s in mice

What is the impact of SARS-CoV-2 infection on semen parameters and sex hormones?

New approach provides better understanding of atherosclerosis in the leg arteries

Study shows the importance of night-time blood pressure assessment for diagnosing hypertension

Clinical suite to help unlock the mysteries of neurological disorders

Blueberries, a tasty intervention against age-related cognitive decline

Investigating a potential new treatment for glioblastomas

Cleveland Clinic’s ROBIN center may pave way for more effective radiation, immunotherapy treatments

Anti-fibrotics found to be safe, effective for interstitial lung disease in patients with rheumatoid arthritis

Can a commercial breath analysis test detect SARS-CoV-2?

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