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Hydrogel-based drug delivery offers hope for post-traumatic osteoarthritis

Post-traumatic osteoarthritis (PTOA) is a condition that affects joints after an injury. Current treatments focus on relieving symptoms but do not prevent or stop the progression of the condition.

1 Apr 2025

Digital twins and ECGI enhance accuracy in arrhythmia treatment

Millions of people around the world live with cardiac arrhythmias. Only in Spain, it is estimated that more than one million citizens suffer from them.

1 Apr 2025

New approach speeds up personalized cancer treatment for young patients

A pan-Canadian team has developed a new way to quickly find personalized treatments for young cancer patients, by growing their tumors in chicken eggs and analyzing their proteins.

1 Apr 2025

New TIL therapy improves treatment's effectiveness in patients with metastatic gastrointestinal cancers

A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment's effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial led by researchers at the National Institutes of Health (NIH).

1 Apr 2025

WINREVAIR™ (sotatercept-csrk) reduced the risk of a composite of all-cause death, lung transplantation and hospitalization for pulmonary arterial hypertension (PAH) by 76% compared to placebo in the phase 3 ZENITH trial

Merck, known as MSD outside of the United States and Canada, today announced the first presentation of results from the Phase 3 ZENITH trial evaluating WINREVAIR™ (sotatercept-csrk) compared to placebo in adults with pulmonary arterial hypertension (PAH, Group 1 PH) WHO* functional class (FC) III or IV at high risk of mortality who were on maximum tolerated background PAH therapy. At a median follow-up of 10.6 months (range, 0.3-26.1), WINREVAIR reduced the relative risk of major morbidity and mortality events (the composite of all-cause death, lung transplantation and PAH worsening-related hospitalization of ≥24 hours) by 76% (HR=0.24 [95% CI, 0.13-0.43]; p<0.0001 [1-sided]) compared to placebo.

1 Apr 2025

Study finds clues to hypertension hidden in electronic health records

A new study from investigators at Mass General Brigham shows that clues about hypertension may be buried in electronic health records (EHR).

1 Apr 2025

ALL ALS Consortium creates a central information hub to accelerate ALS research

The Access for All in ALS (ALL ALS) Consortium announced the launch of its official website, creating a central hub for information about its initiatives and clinical research studies. ALL-ALS.org is designed to inform and engage researchers, clinicians, and current and prospective study participants.

31 Mar 2025

Research challenges traditional oxygen practices in trauma care

When a critically injured patient is admitted to the hospital, how much supplemental oxygen should they receive? New research published this week in JAMA Network Open led by investigators at the University of Colorado School of Medicine suggests it's often less than the current standard.

31 Mar 2025

Defibrillators and CPR cut marathon cardiac deaths in half, study shows

Researchers found that while the rate of cardiac arrests during U.S. marathons and half-marathons remained stable from 2010 to 2023, the likelihood of death from these events dropped by nearly half—thanks to faster emergency response and widespread use of defibrillators.

31 Mar 2025

New genetic discovery sheds light on PHTS-related vascular malformations

During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner.

31 Mar 2025

AI model achieves high accuracy in detecting odontogenic sinusitis in dental X-rays

The Ateneo Laboratory for Intelligent Visual Environments (ALIVE) and international researchers have developed a deep learning model that aims to revolutionize dentistry, with the capability to identify tooth and sinus structures in dental X-rays with an accuracy of 98.2%.

31 Mar 2025

Blood test offers insight into Alzheimer's stage and severity

A newly developed blood test for Alzheimer's disease not only aids in the diagnosis of the neurodegenerative condition but also indicates how far it has progressed, according to a study by researchers at Washington University School of Medicine in St. Louis and Lund University in Sweden.

31 Mar 2025

Swedish researchers identify genetic variants linked to atherosclerosis

Swedish researchers have identified genetic variants that increase the risk of atherosclerosis. The aim is for these new findings to enable earlier detection of atherosclerosis and improved treatment of cardiovascular diseases such as heart attack and stroke.

31 Mar 2025

Embolic protection device does not reduce stroke rate in TAVR procedure

A device designed to remove embolic material—fragments of tissue that can be released into the bloodstream during transcatheter aortic valve replacement (TAVR)—did not result in a reduction in the rate of stroke, according to a randomized trial presented at the American College of Cardiology's Annual Scientific Session.

31 Mar 2025

‘They won’t help me’: Sickest patients face insurance denials despite policy fixes

Sheldon Ekirch spends a lot of time on hold with her health insurance company. Sometimes, as the minutes tick by and her frustration mounts, Ekirch, 30, opens a meditation app on her phone. It was recommended by her psychologist to help with the depression associated with a stressful and painful medical disorder.

31 Mar 2025

AI-based imaging performs equally well as ultrasound in guiding heart procedures

Patients with narrowing of at least 50% in three major coronary arteries did equally well when treated with a minimally invasive stent placement guided either by ultrasound-based imaging or by a novel, artificial-intelligence-powered (AI), non-invasive imaging technique derived from angiography, researchers reported at the American College of Cardiology's Annual Scientific Session (ACC.25).

31 Mar 2025

Racial disparities persist in survival rates for young athletes with cardiac arrest

The overall survival rate of athletes who suffer sudden cardiac arrest has improved over the past decade, but the likelihood of surviving varies by race, where the cardiac arrest occurred and what athletes were doing when they collapsed, according to featured clinical research presented at the American College of Cardiology's Annual Scientific Session (ACC.25) and simultaneously published in JACC.

31 Mar 2025

Study finds no benefit of early IABP use in cardiogenic shock patients

Compared with standard medical care, early use of a temporary intra-aortic balloon pump (IABP) to support heart function in patients who were critically ill with cardiogenic shock caused by heart failure did not improve 60-day survival or enable more patients to successfully transition to long-term treatment, according to featured clinical research presented at the American College of Cardiology's Annual Scientific Session (ACC.25) and simultaneously published in JACC

31 Mar 2025

Does COVID-19 affect heart rate variability after recovery?

Researchers determine the impact of mild COVID-19 on heart rate variability.

31 Mar 2025

FAME-3 study reveals similar outcomes for CABG and PCI in severe triple-vessel heart disease

In sharp contrast to earlier studies, patients with severe triple-vessel heart disease fared equally well whether they underwent open-heart bypass surgery (CABG) or a less invasive procedure called PCI (percutaneous coronary intervention) at five years of follow-up, according to research presented at the American College of Cardiology's Annual Scientific Session.

31 Mar 2025