Mouse Model News and Research

RSS

Metformin could serve as radiosensitizer to treat patients with stage III non-small cell lung cancer

Treating aggressive lung cancer with the diabetes drug metformin along with radiation and chemotherapy may slow tumor growth and recurrence, suggests new preliminary findings from researchers at the Perelman School of Medicine at the University of Pennsylvania being presented during an oral abstract session October 28 at the 15th World Conference on Lung Cancer.

24 Oct 2013

Researchers discover link between NOX4 enzyme and osteoporosis

Genkyotex, the leading developer of NOX enzyme inhibitors, announced today that a group of collaborators have discovered a link between the enzyme NOX4 and development of osteoporosis.

21 Oct 2013

Genetic mutation found to restore translational balance in mice

In a biological quirk that promises to provide researchers with a new approach for studying and potentially treating Fragile X syndrome, scientists at the University of Massachusetts Medical School (UMMS) have shown that knocking out a gene important for messenger RNA (mRNA) translation in neurons restores memory deficits and reduces behavioral symptoms in a mouse model of a prevalent human neurological disease.

21 Oct 2013

Researchers identify novel gene mutation that causes common variable immunodeficiency

A 30-year-old woman with a history of upper respiratory infections had no idea she carried an immunodeficiency disorder - until her 6-year-old son was diagnosed with the same illness.

18 Oct 2013

New discovery may lead to effective treatments for chronic itching

Anyone who has suffered through sleepless nights due to uncontrollable itching knows that not all itching is the same. New research at Washington University School of Medicine in St. Louis explains why.

16 Oct 2013

Cdk5 protein may play crucial role in deadly form of thyroid cancer

A specific protein once thought to exist only in the brain may play a crucial role in a deadly form of thyroid cancer, as well as other cancers, and provide a fresh target for researchers seeking ways to stop its progression, UT Southwestern Medical Center researchers report today in Cancer Cell.

15 Oct 2013

Researchers discover how Fra-1 protein protects the liver from drug-induced liver damage

Drug abuse and alcohol are some of the most frequent causes of liver damage, particularly in developed countries. Such kind of liver damage can cause irreversible liver failure and even cancer. Researchers from the Spanish National Cancer Research Centre have discovered an important new protective role of the Fra-1 protein, which neutralizes the damage caused by agents, such as the analgesic drug acetaminophen (Paracetamol).

12 Oct 2013

Noninvasive tool created to detect pancreatic cancer through risk assessment test using saliva

Pancreatic cancer is one of the deadliest forms of cancer. Most of those with the disease will die within the first year of diagnosis, and just 6 percent will survive five years.

10 Oct 2013

Scientists create model in battle against adenomyosis

For the first time, researchers have created a model that could help unlock what causes adenomyosis, a common gynecological disease that is a major contributor to women having to undergo hysterectomies.

10 Oct 2013

TSRI scientists identify set of compounds to treat multiple sclerosis in new way

Scientists at The Scripps Research Institute (TSRI) have identified a set of compounds that may be used to treat multiple sclerosis (MS) in a new way. Unlike existing MS therapies that suppress the immune system, the compounds boost a population of progenitor cells that can in turn repair MS-damaged nerve fibers.

10 Oct 2013

Neuroscientist receives CAREER grant to research on auditory processing and sound localization

Twenty years ago Khaleel A. Razak was an electronics engineering student focused on creating a telephone for hearing-impaired children in Chennai, India. Today he is a neuroscientist at the University of California, Riverside whose research on how the brain processes everyday sounds may lead to therapies for age-related hearing problems and Fragile X Syndrome.

10 Oct 2013

Key findings may have broad implications for future scleroderma therapy

The Scleroderma Research Foundation today said that researchers at The Johns Hopkins University working in a novel mouse model of Stiff Skin Syndrome have made key discoveries that may have broad implications for future scleroderma therapy.

10 Oct 2013

High levels of HDL have been linked to increased breast cancer risks, enhance cancer aggressiveness

High levels of high density lipoprotein (HDL), also known as the "good cholesterol," are thought to protect against heart disease. However, what's good for one disease may not be good for another.

10 Oct 2013

Thwarting Greatwall May Trigger Mitotic Collapse And Suppress Tumor Development

...

9 Oct 2013

CNIO researcher identifies new molecular mechanism that regulates genome stability, cell proliferation

Cell division is an essential process for the development of an organism. This process, however, can cause tumour growth when it stops working properly. Tumour cells accumulate alterations in their genetic material, and this makes them divide in an uncontrolled fashion, thus encouraging growth of the tumour.

9 Oct 2013

GABA inverse agonist restores learning, memory performances in cognitively-impaired DS mice

A selective GABA inverse agonist has restored cognitive function in a mouse model of Down's syndrome (DS) and has the potential to benefit humans, French researchers have revealed.

8 Oct 2013

Epigenetic regulation linked with pathogenesis of Alzheimer's disease

New evidence presented at the 26th ECNP Congress linking epigenetic regulation with Alzheimer's disease may one day lead to new early diagnostic tests and even novel treatment options for the most common form of dementia.

7 Oct 2013

Whitehead Institute researchers redefine gene mutation that cause Rett syndrome

Whitehead Institute researchers have redefined the function of a gene whose mutation causes Rett syndrome, a neurodevelopmental autism spectrum disorder. This new research offers an improved understanding of the defects found in the neurons of Rett syndrome patients and could lead to novel therapies for the disease.

4 Oct 2013

Diet high in certain type of fat may actually increase metabolism

A diet high in a certain type of fat may actually increase metabolism, according to recent research by Texas Tech University nutrition scientists.

3 Oct 2013

Study shows direct causative link between obesity and risk of pancreatic cancer in mice

Researchers at UCLA's Jonsson Comprehensive Cancer Center (JCCC) have found that mice made obese by being given high-calorie, high-fat diets (HFCD) developed abnormally high numbers of lesions known as pancreatic intraepithelial neoplasias (PanINs), which are known to be precursors to pancreas cancer.

1 Oct 2013

Mouse Model News and Research

Metformin could serve as radiosensitizer to treat patients with stage III non-small cell lung cancer

Researchers discover link between NOX4 enzyme and osteoporosis

Genetic mutation found to restore translational balance in mice

Researchers identify novel gene mutation that causes common variable immunodeficiency

New discovery may lead to effective treatments for chronic itching

Cdk5 protein may play crucial role in deadly form of thyroid cancer

Researchers discover how Fra-1 protein protects the liver from drug-induced liver damage

Noninvasive tool created to detect pancreatic cancer through risk assessment test using saliva

Scientists create model in battle against adenomyosis

TSRI scientists identify set of compounds to treat multiple sclerosis in new way

Neuroscientist receives CAREER grant to research on auditory processing and sound localization

Key findings may have broad implications for future scleroderma therapy

High levels of HDL have been linked to increased breast cancer risks, enhance cancer aggressiveness

Thwarting Greatwall May Trigger Mitotic Collapse And Suppress Tumor Development

CNIO researcher identifies new molecular mechanism that regulates genome stability, cell proliferation

GABA inverse agonist restores learning, memory performances in cognitively-impaired DS mice

Epigenetic regulation linked with pathogenesis of Alzheimer's disease

Whitehead Institute researchers redefine gene mutation that cause Rett syndrome

Diet high in certain type of fat may actually increase metabolism

Study shows direct causative link between obesity and risk of pancreatic cancer in mice

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News