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Novel nasal vaccine approach induces potent lung immunity and protection against SARS-CoV-2

Researchers from the Centenary Institute and the University of Sydney have developed a new nasal vaccination strategy that induces potent lung immunity and protection against the SARS-CoV-2 coronavirus.

16 Nov 2022

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

A study published in the journal Frontiers in Immunology describes that the third booster dose of coronavirus disease 2019 (COVID-19) effectively induces an immune response against immunologically more fit variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the immunity induced by the booster vaccination is transient and gradually declines over time.

15 Nov 2022

Smoking marijuana damages the lungs more than tobacco

Lungs of marijuana smokers exhibit greater levels of airway inflammatory markers and emphysema as compared to those of tobacco-only smokers.

15 Nov 2022

Vitamin D can reduce severity and spread of COVID-19

In a recent study published in the Scientific Reports journal, researchers in the United States assessed the relationship between supplementation with vitamin D and coronavirus disease 2019 (COVID-19) and related mortality.

15 Nov 2022

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

In a recent study published in the journal npj Vaccines, researchers in China designed, produced, and evaluated the neutralization efficacy of a recombinant coronavirus disease 2019 (COVID-19) vaccine containing four hot-spot substitution mutations based on a prefusion-stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) trimer.

15 Nov 2022

SARS-CoV-2 transmission among asymptomatic cases is lower

In a recent study published in the BMC Medicine journal, researchers at the Norwegian Institute of Public Health explored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission among asymptomatic cases.

15 Nov 2022

Research sheds light on cardiac pathology mechanisms of COVID-19

Researchers compared cardiac autopsy samples from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive cases with age-matched samples from influenza hemagglutinin 1 neuraminidase 1 (H1N1) cases, non-influenza lymphocytic myocarditis cases, and heart tissue with no inflammation to understand the mechanisms underlying the pathology of the cardiac complications during coronavirus disease 2019 (COVID-19).

15 Nov 2022

Unique cellular signature can accurately detect obstructive sleep apnea in children

Researchers from the University of Missouri School of Medicine have discovered how obstructive sleep apnea (OSA) changes the profiles of immune cells in the blood, leading to a unique cellular signature that can accurately detect obstructive sleep apnea in children.

15 Nov 2022

Polyphenols in Mediterranean diet may modulate COVID-19 inflammation

Researchers discuss the beneficial role of polyphenolic plant compounds in the Mediterranean diet in the prevention and treatment of COVID-19.

15 Nov 2022

What are the current challenges and future directions of mRNA nanomedicine?

Researchers presented challenges related to the clinical translation of messenger ribonucleic acid (mRNA) technology, recent innovations and future directions to improve the clinical efficacy of mRNA nanomedicine.

15 Nov 2022

Early mobility contributes to higher survival rates for COVID-19 patients receiving ECMO

A Texas cardiac subspecialty hospital with seven years of experience with extracorporeal membrane oxygenation (ECMO) changed its treatment paradigm during the COVID-19 pandemic, finding that progressive mobility and a more aggressive application of rehabilitation therapies contributed to significantly higher survival rates for its patients with COVID-19 receiving ECMO.

15 Nov 2022

Five important things to know about polio

Public Health authorities have warned health care workers to be on the alert for polio, yet most physicians will not be familiar with presentation of this highly infectious, life-threatening disease.

15 Nov 2022

What is the association between diabetes and SARS-CoV-2 infections?

Researchers explored whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can expedite or trigger the development of diabetes mellitus (DM).

15 Nov 2022

Do SSRIs lower the risk of long COVID?

Researchers conducted a retrospective study to determine whether SSRIs with immunomodulatory and antiplatelet properties can decrease the risk of post-acute sequelae of COVID-19 (PASC).

15 Nov 2022

Short-term outcomes in pregnant patients with COVID-19 who received nirmatrelvir–ritonavir treatment

Researchers investigated the short-term outcomes of treating pregnant patients exhibiting mild to moderate symptoms of COVID-19 with Paxlovid, which is a combination of the antivirals nirmatrelvir and ritonavir.

15 Nov 2022

Hemagglutinin stem immunogens may hold the key for broad protection against influenza A viruses

Researchers proposed that vaccines targeting the immunosubdominant yet conserved hemagglutinin (HA) stem could trigger broadly neutralizing antibodies (bnAbs) against influenza A viruses.

15 Nov 2022

Study points to a pathogenic role for compromised anti-SARS-CoV-2 responses in cerebrospinal fluid

Researchers used a high throughput systems serology method to compare serum and CSF samples from SARS-CoV-2 infected individuals with and without long COVID symptoms to determine changes in the SARS-CoV-2 humoral immune responses.

15 Nov 2022

Prevalence and severity of liver enzyme alterations in COVID-19 and association with patient-centered outcomes

Researchers examined the prevalence of changes in liver enzymes in COVID-19.

15 Nov 2022

The origin of COVID-19: wildlife trade rather than laboratory leak?

A recent opinion piece published in PNAS discussed the sequence of events concerning the COVID-19 pandemic to provide evidence against the alleged leak of SARS-CoV-2 and the Ebola virus from viral research laboratories in Wuhan, China, and West Africa, respectively.

15 Nov 2022

The impact of lung remodeling from prior helminth infection on SARS-CoV-2 disease pathogenesis

A recent study reported that helminth exposure enhances viral clearance and survival of mice challenged with SARS-CoV-2.

15 Nov 2022

Respiratory News and Research

Novel nasal vaccine approach induces potent lung immunity and protection against SARS-CoV-2

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

Smoking marijuana damages the lungs more than tobacco

Vitamin D can reduce severity and spread of COVID-19

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

SARS-CoV-2 transmission among asymptomatic cases is lower

Research sheds light on cardiac pathology mechanisms of COVID-19

Unique cellular signature can accurately detect obstructive sleep apnea in children

Polyphenols in Mediterranean diet may modulate COVID-19 inflammation

What are the current challenges and future directions of mRNA nanomedicine?

Early mobility contributes to higher survival rates for COVID-19 patients receiving ECMO

Five important things to know about polio

What is the association between diabetes and SARS-CoV-2 infections?

Do SSRIs lower the risk of long COVID?

Short-term outcomes in pregnant patients with COVID-19 who received nirmatrelvir–ritonavir treatment

Hemagglutinin stem immunogens may hold the key for broad protection against influenza A viruses

Study points to a pathogenic role for compromised anti-SARS-CoV-2 responses in cerebrospinal fluid

Prevalence and severity of liver enzyme alterations in COVID-19 and association with patient-centered outcomes

The origin of COVID-19: wildlife trade rather than laboratory leak?

The impact of lung remodeling from prior helminth infection on SARS-CoV-2 disease pathogenesis

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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