Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Researchers report discovery of new gene linked to Tau accumulation in AD

Tau pathology is one of the defining features of Alzheimer disease (AD), which is the most common form of dementia in older age.

25 Mar 2017

Immunotherapy drug becomes first FDA-approved treatment for metastatic MCC

The U.S. Food and Drug Administration yesterday granted accelerated approval to the checkpoint inhibitor Bavencio (avelumab) for the treatment of patients with metastatic Merkel cell carcinoma (MCC), including those who have not received prior chemotherapy.

25 Mar 2017

New gene linked to Tau pathology

Investigators at Rush University Medical Center and the Brigham and Women's Hospital in Boston reported the discovery of a new gene that is associated with susceptibility to a common form of brain pathology called Tau that accumulates in several different conditions, including Alzheimer's disease, certain forms of dementia and Parkinsonian syndromes as well as chronic traumatic encephalopathy that occurs with repeated head injuries.

24 Mar 2017

PRECISION Panc project aims to develop personalised treatments for pancreatic cancer patients

The development of new treatments for pancreatic cancer is set to be transformed by a network of clinical trials, aiming to find the right trial for the right patient, after a £10 million investment from Cancer Research UK.

23 Mar 2017

New genetic biomarker for colon cancer may lead to development of personalized treatment

Researchers at Baylor Scott & White Research Institute identified a new genetic biomarker for colon cancer that may lead to development of more targeted treatment of the disease.

22 Mar 2017

Study identifies urinary biomarker that may help monitor progression of ALS

A study in Neurology suggests that analyzing levels of the protein p75ECD in urine samples from people with amyotrophic lateral sclerosis (ALS) may help monitor disease progression as well as determine the effectiveness of therapies.

22 Mar 2017

UC researchers advocate ‘precision medicine’ approach to studying and treating Parkinson's disease

Two landmark publications with one or more co-authors from the University of Cincinnati Gardner Neuroscience Institute outline a transformative approach to defining, studying and treating Parkinson's disease.

22 Mar 2017

Penn scientists discover method that appears to provide early warning of transplant rejection

Approximately 30,000 organ transplants occur in the United States each year. However, between 20 and 50 percent—depending on the organ type—of the transplanted organs fail within five years, most often because the recipient's immune system attacks, or "rejects," the donated organ.

21 Mar 2017

Researchers highlight how biomarkers after ACL reconstruction may signal severity of PTOA later in life

A majority of Anterior Cruciate Ligament (ACL) reconstruction patients develop a condition known as posttraumatic osteoarthritis (PTOA) within 15 years of surgery, which can be debilitating and limit activity. Researchers presenting their work at the American Orthopaedic Society for Sports Medicine's Specialty Day in San Diego are highlighting how a set of biomarkers on the day of surgery may explain why some individuals have worse PTOA than others after two years.

20 Mar 2017

NeoGenomics, Definiens expand alliance to develop novel biomarker assays for clinical trials and testing

NeoGenomics, Inc., a leading provider of cancer-focused genetic testing services, and Definiens, the leader in Tissue Phenomics solutions from biomarker discovery to meaningful diagnostics, today announced that they have expanded their alliance to develop and automate the analysis of new biomarker assays for clinical trials and routine clinical testing.

20 Mar 2017

Biomarker blood test detects recurrences of lung cancer before conventional imaging methods

Results from a prospective clinical trial showed that a blood test looking at specific biomarkers was able to detect recurrences of lung cancer an average of six months before conventional imaging methods found evidence of recurrence.

17 Mar 2017

First physiological test opens door to early diagnosis of autism

An algorithm based on levels of metabolites found in a blood sample can accurately predict whether a child is on the Autism spectrum of disorder (ASD), based upon a recent study.

16 Mar 2017

New biomarker may predict trajectory of TBI recovery in children

A new biomarker may help predict which children will take longer to recover from a traumatic brain injury (TBI), according to a preliminary study published in the March 15, 2017, online issue of Neurology, the medical journal of the American Academy of Neurology.

16 Mar 2017

CUMC researchers discover common genetic variant that impacts brain aging

Columbia University Medical Center researchers have discovered a common genetic variant that greatly impacts normal brain aging, starting at around age 65, and may modify the risk for neurodegenerative diseases.

15 Mar 2017

Changes in the brain regions that process speech may be potential predictor of early dementia

Early dementia is typically associated with memory and thinking problems; but older adults should also be vigilant about hearing and communication problems, suggest recent findings in a joint Baycrest-University of Memphis study.

15 Mar 2017

Low levels of allopregnanolone hormone may predict risk of postpartum depression

In a small-scale study of women with previously diagnosed mood disorders, Johns Hopkins researchers report that lower levels of the hormone allopregnanolone in the second trimester of pregnancy were associated with an increased chance of developing postpartum depression in women already known to be at risk for the disorder.

14 Mar 2017

New biomarkers may help in diagnosis and management of Crohn's disease

The diagnosis, understanding and management of Crohn's disease may have just received a helping hand from a joint ASU Biodesign Institute and Mayo Clinic study aimed at developing a better blood test for the disease.

9 Mar 2017

Researchers develop innovative nanobiodevice that enables rapid detection of cancer biomarker

Like DNA, ribonucleic acid (RNA) is a type of polymeric biomolecule essential for life, playing important roles in gene processing.

8 Mar 2017

Research findings provide new conceptual framework for understanding brain inflammation after injury

Researchers have identified a new mechanism by which inflammation can spread throughout the brain after injury. This mechanism may explain the widespread and long-lasting inflammation that occurs after traumatic brain injury, and may play a role in other neurodegenerative diseases.

8 Mar 2017

New biomarker 'Bim' could help predict optimal treatment for metastatic melanoma patients

Over the past few years, checkpoint blockade immunotherapies have revolutionized cancer treatment and helped many patients who were previously considered untreatable.

8 Mar 2017

Biomarker News and Research

Further Reading

Researchers report discovery of new gene linked to Tau accumulation in AD

Immunotherapy drug becomes first FDA-approved treatment for metastatic MCC

New gene linked to Tau pathology

PRECISION Panc project aims to develop personalised treatments for pancreatic cancer patients

New genetic biomarker for colon cancer may lead to development of personalized treatment

Study identifies urinary biomarker that may help monitor progression of ALS

UC researchers advocate ‘precision medicine’ approach to studying and treating Parkinson's disease

Penn scientists discover method that appears to provide early warning of transplant rejection

Researchers highlight how biomarkers after ACL reconstruction may signal severity of PTOA later in life

NeoGenomics, Definiens expand alliance to develop novel biomarker assays for clinical trials and testing

Biomarker blood test detects recurrences of lung cancer before conventional imaging methods

First physiological test opens door to early diagnosis of autism

New biomarker may predict trajectory of TBI recovery in children

CUMC researchers discover common genetic variant that impacts brain aging

Changes in the brain regions that process speech may be potential predictor of early dementia

Low levels of allopregnanolone hormone may predict risk of postpartum depression

New biomarkers may help in diagnosis and management of Crohn's disease

Researchers develop innovative nanobiodevice that enables rapid detection of cancer biomarker

Research findings provide new conceptual framework for understanding brain inflammation after injury

New biomarker 'Bim' could help predict optimal treatment for metastatic melanoma patients

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