Preclinical News and Research

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Researchers use MRI to watch how electrical stimulation could cure gastrointestinal disorders

More than 60 million people in the U.S. suffer from disorders in the gastrointestinal tract that could be cured by electrical stimulation, but scientists don't fully understand the therapy's effects on a critical organ: the stomach.

25 Oct 2018

Bioengineering scientists propose new paradigm for research into cardiovascular diseases

Thrombosis-on-a-chip, vasculature-on-a-chip and engineered models of human cardiac fibrosis are just a few of the new technologies revolutionizing research into human cardiovascular disease--a condition responsible for 17 million deaths per annum globally.

25 Oct 2018

Scientists engineer antiviral peptide that exploits Achilles' heel of Zika virus

Scientists at Nanyang Technological University, Singapore have engineered an antiviral peptide that exploits the Zika virus at its Achilles' heel - the viral membrane - hence stopping the virus from causing severe infections.

24 Oct 2018

Scientists identify new target for battling deadly form of leukemia

UT Southwestern scientists, working with colleagues at a sister institution in Houston, have identified a new target for battling a deadly form of leukemia.

24 Oct 2018

Emergex completes toxicology testing on gold nanoparticle carrier system for vaccine platform

Emergex Vaccines Holding Limited, a biotechnology company pioneering a new approach to synthetic vaccine development in the field of infectious diseases, today announces the successful completion of preclinical toxicology testing on the gold nanoparticle carrier system that forms the fundamental basis for Emergex's entire infectious disease vaccine platform.

24 Oct 2018

Scientists develop nanodevice to deliver immunotherapy without side effects

Houston Methodist scientists have developed a nanodevice to deliver immunotherapy without side effects to treat triple-negative breast cancer.

24 Oct 2018

Hippocampal avoidance during whole-brain radiotherapy reduces risk of cognitive decline

Whole-brain radiotherapy can be delivered more safely to patients with brain metastases by avoiding the hippocampus according to a randomized phase III NRG Oncology trial presented at the American Society for Radiation Oncology Annual Meeting.

23 Oct 2018

New partnership aims to tackle cancer health disparities

Although cancer affects all populations in the United States, certain ethnic populations bear a disproportionate burden of cancer compared with other groups, according to the National Cancer Institute.

23 Oct 2018

Polyganics begins first-in-human clinical trial of LIQOSEAL for reducing CSF leakage

Polyganics today announced that it has initiated enrollment of patients into a first-in-human clinical trial of LIQOSEAL, its dura sealant patch.

23 Oct 2018

Forbius initiates Phase 2a trial evaluating efficacy, safety of AVID100 in patients with squamous NSCLC

Forbius, a clinical stage company developing biotherapeutics targeting EGFR and TGF-β pathways, today announced that the first patient has been dosed in a Phase 2a trial evaluating the efficacy and safety of AVID100 in patients with squamous non-small cell lung cancer whose tumors overexpress epidermal growth factor receptor.

23 Oct 2018

New 17-item questionnaire may help detect GI disorders in children with autism

Anger, aggression, and other troubling behavior problems in kids with autism are often treated as psychological issues, but in many cases the problems can be traced to gastrointestinal distress.

23 Oct 2018

New topical gel can prevent pesticide-induced toxicity and lethality

Farmers are exposed to toxic pesticides, through skin contact and inhalation, during the spraying of pesticides. This is a severe health hazard. In the last year, from the Vidharbha region in Maharashtra alone, spraying is thought to have led to over 40 deaths, 25 cases of lost vision, and over 1000 hospitalizations.

22 Oct 2018

Researchers develop promising targeted strategy to treat chemo-resistant blood cancer

Researchers from The Ottawa Hospital and the University of Ottawa have developed a promising targeted strategy to treat chemotherapy-resistant acute myeloid leukemia and a diagnostic test to determine which AML patients would most likely benefit from this treatment.

22 Oct 2018

Deciphera presents Phase 1 clinical results of DCC-2618 in patients with gastrointestinal stromal tumors

Deciphera Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, announced the presentation today of updated preliminary results from its ongoing Phase 1 clinical study of DCC-2618, the company's broad-spectrum KIT and PDGFRα inhibitor, in patients with gastrointestinal stromal tumors as a proffered paper presentation at the European Society of Medical Oncology 2018 Congress in Munich, Germany.

22 Oct 2018

Incyte announces Phase 2 FIGHT-202 trial data in patients with cholangiocarcinoma

Incyte Corporation announces updated data from its ongoing Phase 2 FIGHT-202 trial evaluating pemigatinib (INCB54828), its selective fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced/metastatic or surgically unresectable cholangiocarcinoma (bile duct cancer) who failed at least one previous treatment.

22 Oct 2018

ImmunoGen announces study results of platinum-resistant ovarian cancer therapy at ESMO 2018 Congress

ImmunoGen, Inc., a leader in the expanding field of antibody-drug conjugates for the treatment of cancer, today announced initial safety and preliminary anti-tumor activity from the FORWARD II expansion cohort assessing mirvetuximab soravtansine in combination with Merck's anti-PD-1 therapy, KEYTRUDA (pembrolizumab).

22 Oct 2018

Newly developed synthetic DNA molecule may one day be used as 'vaccine' for prostate cancer

Researchers from City of Hope, a world-renowned comprehensive cancer center and independent biomedical research institution, have developed a synthetic DNA molecule that is programmed to jump-start the immune system to eradicate genetically distinct types of prostate cancer.

19 Oct 2018

Scripps researchers successfully test potential new smoking-cessation treatment in rodents

Scientists at Scripps Research have successfully tested a potential new smoking-cessation treatment in rodents.

19 Oct 2018

Mice study shows antibiotics are not always necessary to cure sepsis

Biochemists, microbiologists, drug discovery experts and infectious disease doctors have teamed up in a new study that shows antibiotics are not always necessary to cure sepsis in mice.

17 Oct 2018

Researchers awarded grant to advance testing of experimental heroin vaccine

Researchers at the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research and SUNY Upstate Medical University in Syracuse, N.Y., have been awarded a grant to advance an experimental heroin vaccine through Phase I/IIa clinical trials to assess both its safety and its efficacy against a morphine challenge.

17 Oct 2018

Preclinical News and Research

Researchers use MRI to watch how electrical stimulation could cure gastrointestinal disorders

Bioengineering scientists propose new paradigm for research into cardiovascular diseases

Scientists engineer antiviral peptide that exploits Achilles' heel of Zika virus

Scientists identify new target for battling deadly form of leukemia

Emergex completes toxicology testing on gold nanoparticle carrier system for vaccine platform

Scientists develop nanodevice to deliver immunotherapy without side effects

Hippocampal avoidance during whole-brain radiotherapy reduces risk of cognitive decline

New partnership aims to tackle cancer health disparities

Polyganics begins first-in-human clinical trial of LIQOSEAL for reducing CSF leakage

Forbius initiates Phase 2a trial evaluating efficacy, safety of AVID100 in patients with squamous NSCLC

New 17-item questionnaire may help detect GI disorders in children with autism

New topical gel can prevent pesticide-induced toxicity and lethality

Researchers develop promising targeted strategy to treat chemo-resistant blood cancer

Deciphera presents Phase 1 clinical results of DCC-2618 in patients with gastrointestinal stromal tumors

Incyte announces Phase 2 FIGHT-202 trial data in patients with cholangiocarcinoma

ImmunoGen announces study results of platinum-resistant ovarian cancer therapy at ESMO 2018 Congress

Newly developed synthetic DNA molecule may one day be used as 'vaccine' for prostate cancer

Scripps researchers successfully test potential new smoking-cessation treatment in rodents

Mice study shows antibiotics are not always necessary to cure sepsis

Researchers awarded grant to advance testing of experimental heroin vaccine

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