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Pabetalone (RVX-208) to be tested in proof-of-concept pilot study in complement mediated diseases

Resverlogix Corp. announced today the commencement of an Orphan Disease Program specific for Complement Mediated Diseases. New data generated by Resverlogix has demonstrated that BET inhibition by apabetalone (RVX-208) has effects on multiple biological pathways that underlie disease pathology.

24 Sep 2015

Study demonstrates potential of FCPCs as new source for cartilage regeneration

The self-repair of injured cartilage is difficult for several reasons, foremost of which is the lack of blood supply to the tissue. Therapeutic efforts aimed at cartilage repair are often not optimal. Surgical repair techniques often lead to the formation of fibrocartilage, which is weaker and less durable. Although cell transplantation aimed at cartilage repair has been carried out using mesenchymal stem cells (MSCs), varying outcomes have resulted, despite the propensity of MSCs to proliferate and differentiate.

23 Sep 2015

AmpliPhi's novel bacteriophage therapy demonstrates comparable efficacy to vancomycin in S. aureus lung infection model

AmpliPhi Biosciences Corporation, a global leader in the development of bacteriophage-based antibacterial therapies to treat drug-resistant infections, today announced experimental results highlighting that its prototype bacteriophage cocktail demonstrated comparable efficacy to vancomycin in reduction of Staphylococcus aureus in a murine lung infection model.

22 Sep 2015

$Common Alzheimer's disease drug increases bone density, reduces fracture risks$

Common Alzheimer's disease drug increases bone density, reduces fracture risks

The most common drug used to treat Alzheimer's disease increases bone mass in mice, according to one of the first research articles published in the new open access journal Heliyon. The authors of the study, from Saitama Medical University in Japan, say this means the drug could also be used to treat bone loss diseases like osteoporosis and periodontitis, following further clinical research.

21 Sep 2015

Combination of TXA709 and cefdinir demonstrates synergistic antibacterial activity against MRSA

TAXIS Pharmaceuticals, a drug-discovery company focused on developing a new class of antibiotic agents to treat life-threatening, multidrug-resistant bacterial infections, announced the presentation of results demonstrating the synergistic antibacterial activity of its lead clinical candidate, TXA709, when combined with cefdinir, a third-generation cephalosporin antibiotic.

19 Sep 2015

Benitec Biopharma initiates new site for ongoing Phase 1/2a TT-034 trial for hepatitis C

Benitec Biopharma Limited, a clinical-stage biotechnology company developing innovative therapeutics based on its gene-silencing technology, DNA-directed RNA interference (ddRNAi), is pleased to announce it has initiated a new site for its ongoing Phase 1/2a TT-034 trial at the Methodist Health System Clinical Research Institute in Dallas, Texas.

16 Sep 2015

Precise mouse brain map may provide new insights into brain circuits and origins of mental illnesses

Scientists at Duke University have released a highly detailed model of connections in the mouse brain that could provide generations of neuroscientists new insights into brain circuits and origins of mental illness, such as depression and schizophrenia.

16 Sep 2015

NUS researchers develop new technique to observe nano-bio interactions

Researchers at the National University of Singapore have developed a technique to observe, in real time, how individual blood components interact and modify advanced nanoparticle therapeutics.

16 Sep 2015

New strategy improves bone repair by boosting survival rate of transplanted stem cells

Stem cell therapies are often limited by low survival of transplanted stem cells and the lack of precise control over their differentiation into the terminal cell types needed to repair or replace injured tissues. Now, a team led by Wyss Institute Core Faculty member David Mooney, Ph.D., has developed a new strategy - embedding stem cells into porous, transplantable hydrogels - that has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation.

15 Sep 2015

Researchers identify new epigenetic markers for colorectal cancer

Researchers at Nanjing University, China, found new epigenetic markers for colorectal cancer which may offer a new approach for treatment.

14 Sep 2015

Luteolin may reduce risk of breast cancer in some women, find MU researchers

More than 100 women die from breast cancer every day in the United States. The odds increase in postmenopausal women who have taken a combined estrogen and progestin hormone replacement therapy; these women also have an increased risk of developing progestin-accelerated breast tumors.

11 Sep 2015

Research provides new approach for studying neural circuits that control behavior

Researchers at the University of Massachusetts Medical School are the first to show that it's possible to reverse the behavior of an animal by flipping a switch in neuronal communication.

9 Sep 2015

Why do we sleep? An interview with Professor Wisden

It is true that we still do not know why we need to sleep every night. Sleep is essential for health. We have to do it every day. But nobody yet knows why. This fact amazes me.

8 Sep 2015

Four Next-Generation Preclinical Imaging Systems introduced

Bruker today introduces four important new preclinical imaging systems at the World Molecular Imaging Congress 2015

From Bruker BioSpin Division 3 Sep 2015

Preventing the build up of dangerous biofilms, ESCMID publishes guidelines

The European Society of Clinical Microbiology and Infectious Disease (ESCMID) – an organization that explores the risks and best practices in infectious disease – advocates the need for greater education, guidance and research on the build-up, treatment and prevention of biofilms, which contribute to antimicrobial resistance.

2 Sep 2015

Shire and Sangamo revise agreement to expedite development of ZFP Therapeutics for Huntington's disease, hemophilia A and B

Sangamo BioSciences, Inc., a leader in therapeutic genome editing, announced today that the company and its collaborator, Shire plc, have agreed to revise their January 2012 collaboration and license agreement to expedite the development of ZFP Therapeutics for hemophilia A and B and Huntington's disease.

2 Sep 2015

High speed cellFRAP imaging platform for dynamic in-vivo processes

Olympus introduces a flexible and accurate cellFRAP imaging platform specifically for the acquisition, monitoring and analysis of dynamic in-vivo processes by photomanipulation techniques. The easy-to-use platform delivers excellent optical performance and µs-precise control.

1 Sep 2015

Biocompatible scaffold enables beating heart cells to snap together like Velcro

Engineers at the University of Toronto just made assembling functional heart tissue as easy as fastening your shoes. The team has created a biocompatible scaffold that allows sheets of beating heart cells to snap together just like Velcro™.

29 Aug 2015

Novel chemical virus can cross double lipid layer surrounding cells to release drugs

Viruses are able to redirect the functioning of cells in order to infect them. Inspired by their mode of action, scientists from the CNRS and Université de Strasbourg have designed a "chemical virus" that can cross the double lipid layer that surrounds cells, and then disintegrate in the intracellular medium in order to release active compounds.

29 Aug 2015

Cholinergic neurons in basal forebrain broadcast message throughout the cerebral cortex

When a large combat unit, widely dispersed in dense jungle, goes to battle, no single soldier knows precisely how his actions are affecting the unit's success or failure. But in modern armies, every soldier is connected via an audio link that can instantly receive broadcasts - reporting both positive and negative surprises - based on new intelligence. The real-time broadcasts enable dispersed troops to learn from these reports and can be critical since no solider has an overview of the entire unit's situation.

28 Aug 2015

in vivo News and Research

Pabetalone (RVX-208) to be tested in proof-of-concept pilot study in complement mediated diseases

Study demonstrates potential of FCPCs as new source for cartilage regeneration

AmpliPhi's novel bacteriophage therapy demonstrates comparable efficacy to vancomycin in S. aureus lung infection model

Common Alzheimer's disease drug increases bone density, reduces fracture risks

Combination of TXA709 and cefdinir demonstrates synergistic antibacterial activity against MRSA

Benitec Biopharma initiates new site for ongoing Phase 1/2a TT-034 trial for hepatitis C

Precise mouse brain map may provide new insights into brain circuits and origins of mental illnesses

NUS researchers develop new technique to observe nano-bio interactions

New strategy improves bone repair by boosting survival rate of transplanted stem cells

Researchers identify new epigenetic markers for colorectal cancer

Luteolin may reduce risk of breast cancer in some women, find MU researchers

Research provides new approach for studying neural circuits that control behavior

Why do we sleep? An interview with Professor Wisden

Four Next-Generation Preclinical Imaging Systems introduced

Preventing the build up of dangerous biofilms, ESCMID publishes guidelines

Shire and Sangamo revise agreement to expedite development of ZFP Therapeutics for Huntington's disease, hemophilia A and B

High speed cellFRAP imaging platform for dynamic in-vivo processes

Biocompatible scaffold enables beating heart cells to snap together like Velcro

Novel chemical virus can cross double lipid layer surrounding cells to release drugs

Cholinergic neurons in basal forebrain broadcast message throughout the cerebral cortex

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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