Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in PTPN2.

17 Jan 2025

Oil-based solution enables room temperature storage of protein therapeutics

A new storage technique can keep protein-based drugs and vaccines stable without keeping them cold. The discovery, led by researchers at Penn State, could eliminate the need for refrigeration for hundreds of life-saving medicines like insulin, monoclonal antibodies and viral vaccines.

17 Jan 2025

Bidirectional movement drives DNA loop formation

Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make loops into DNA could move in one direction only. The discovery, which is published in Cell, is key to understanding how these motors shape our genome and regulate our genes.

17 Jan 2025

Non-toxic bacterial therapy shows promise for targeting tumors

A University of Massachusetts Amherst-Ernest Pharmaceuticals team of scientists has made "exciting," patient-friendly advances in developing a non-toxic bacterial therapy, BacID, to deliver cancer-fighting drugs directly into tumors.

16 Jan 2025

Scientists discover new mechanism behind Huntington’s disease brain cell death

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.

16 Jan 2025

Protein CD74 could predict immunotherapy response in bowel cancer

Researchers at the Francis Crick Institute and Barts Cancer Institute, Queen Mary University of London, have shown that the amount of a protein called CD74 can indicate which people with bowel cancer may respond best to immunotherapy.

16 Jan 2025

AstraZeneca's Pioneering Research in Heart Failure and ATTR-CM

Mina Makar highlights AstraZeneca's commitment to advancing heart failure research and innovative therapies, addressing critical needs in cardiovascular health.

16 Jan 2025

New research uncovers mechanisms behind osteoarthritis risk in postmenopausal women

Osteoarthritis (OA) is a condition that disproportionally affects postmenopausal women, and the millions affected can attest to the pain, reduced mobility and diminished quality of life that comes from this disease.

16 Jan 2025

Study uncovers why lupus patients have weaker response to COVID-19 vaccines

A recent study by Emory University researchers provides new insights into why the mRNA vaccines developed to fight COVID-19 in 2021 are less effective in patients with autoimmune diseases.

16 Jan 2025

Drug in breast cancer trials shows potential for treating blood cancers

Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.

16 Jan 2025

Study unveils role of TLE6 in male sperm development

Infertility is a major global challenge associated with physiological and psychological impact. Genetic mutations that affect early embryonic development, oocyte (egg cell) maturation, and fertilization have recently been studied as causes of infertility.

16 Jan 2025

Could mulberry extract be the key to fighting obesity-induced reproductive dysfunction?

Research indicates mulberry extract's efficacy in addressing obesity-related male infertility, enhancing reproductive outcomes through bioactive compounds.

16 Jan 2025

Targeting tertiary lymphoid structures for cancer treatment

A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell clusters called tertiary lymphoid structures (TLSs) in response to foreign threats such as cancer.

16 Jan 2025

Mouse protein disrupts cancer-causing epigenetic changes in human colorectal cancer

A little-known mouse protein disrupts cancer-causing chemical changes to genes associated with human colorectal cancer cells and potentially could be used to treat solid tumors, according to a new study from researchers at the Johns Hopkins Kimmel Cancer Center and the Chinese Academy of Sciences.

16 Jan 2025

T-DM1 reduces long-term risk of death in HER2-positive breast cancer patients

In patients with high-risk HER2-positive breast cancer, post-surgery, or adjuvant, treatment with trastuzumab emtansine (T-DM1) reduced the long-term risk of death or invasive disease by 46% and improved survival compared to trastuzumab alone, according to the final results of the phase 3 KATHERINE clinical trial led by researchers from the University of Pittsburgh and UPMC Hillman Cancer Center.

16 Jan 2025

Xenon gas offers potential neuroprotective effects for Alzheimer's patients

Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research from Mass General Brigham and Washington University School of Medicine in St. Louis points to a novel-and noble-approach: using Xenon gas.

16 Jan 2025

Pheno Therapeutics receives clinical trial authorization for novel multiple sclerosis therapeutic

Pheno Therapeutics Limited., a biotechnology company focused on the discovery and development of small molecule therapeutics for the treatment of neurological diseases, announced today it has received clinical trial authorization (CTA) from the UK’s MHRA (Medicines and Healthcare products Regulatory Agency) for its lead candidate, PTD802.

15 Jan 2025