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EGFR biomarkers predict NSCLC response to vandetanib

Biomarker analyses of tumour samples from the ZODIAC study indicate that epidermal growth factor receptor gene copy number and mutation status may help identify the non-small-cell lung cancer patients most likely to benefit from treatment with vandetanib plus docetaxel.

20 Aug 2014

Choroidal consequences differ between anti-VEGF therapies

Aflibercept’s possession of a fragment crystallisable region may make it more likely to induce unwanted effects in retinal and choroidal vessels than other anti-vascular endothelial growth factor therapies, say researchers.

20 Aug 2014

Early intervention hope for childhood achromatopsia

Researchers have found that children with achromatopsia have milder foveal pathology than their older counterparts, highlighting a potential opportunity for early intervention with gene therapy.

20 Aug 2014

CD157 important in malignant pleural mesothelioma

CD157 plays a pivotal role in the progression of malignant pleural mesothelioma and may be useful in the stratification of patients into different prognostic groups, Italian research suggests.

20 Aug 2014

Trovagene announces results from clinical studies on urine-based diagnostic test for detection of HPV

Trovagene, Inc., a developer of cell-free molecular diagnostics, announced today that results from two clinical studies will be presented at the 29th International Papillomavirus conference for the Company's urine-based diagnostic test for the detection of high risk strains of Human Papillomavirus.

20 Aug 2014

Glenmark announces discovery and initiation of IND enabling studies of innovative bispecific antibody

Glenmark Pharmaceuticals S.A. (GPSA), a wholly owned subsidiary of Glenmark Pharmaceuticals Limited India (GPL), announces the discovery and initiation of IND enabling studies of a novel clinical development candidate, GBR 1302, a HER2xCD3 bispecific antibody.

20 Aug 2014

Scientists suggest that type-1 and type-2 diabetes are result of same mechanism

Work by scientists at the Universities of Manchester and Auckland suggest that both major forms of diabetes are the result of the same mechanism.

From The University of Manchester 20 Aug 2014

Longitude and NovaQuest acquire California Cryobank

California Cryobank, a global leader in reproductive tissue donor services and storage and stem cell banking, announced today that it has been acquired by equity investors Longitude Venture Partners II, L.P. and NovaQuest Pharma Opportunities Fund III, L.P..

20 Aug 2014

Analysis of Candida glabrata fungus mutations reveals new genes that confer anti-fungal tolerance

A group of researchers at the Max F. Perutz Laboratories has created one of the three world's largest gene libraries for the Candida glabrata yeast, which is harmful to humans.

20 Aug 2014

Newborn screening indicates that incidence of SCID is higher than previously believed

Newborn screening performed in numerous states indicates that the incidence of the potentially life-threatening disorder, severe combined immunodeficiency, is higher than previously believed, at 1 in 58,000 births, although there is a high rate of survival, according to a study in the August 20 issue of JAMA.

20 Aug 2014

Researchers made important step towards creating medical nanorobots

Researchers from the Institute of General Physics of the Russian Academy of Sciences, the Institute of Bioorganic Chemistry of the Russian Academy of Sciences and MIPT have made an important step towards creating medical nanorobots.

20 Aug 2014

Study helps explain why sleep becomes more fragmented with age

As people grow older, they often have difficulty falling asleep and staying asleep, and tend to awaken too early in the morning.

20 Aug 2014

Houston Methodist researchers receive $1.6M from NIH to study pathological antibodies

Transplant immunologists at the Houston Methodist Research Institute will receive about $1.6 million over four years from the National Institute of Allergy and Infectious Diseases to study pathological antibodies produced from activated memory B cells during the chronic rejection of organ transplants.

20 Aug 2014

Regulation of stem cells in zebrafish embryos results in surprising insights into Alzheimer's Disease

New fundamental knowledge about the regulation of stem cells in the nerve tissue of zebrafish embryos results in surprising insights into neurodegenerative disease processes in the human brain.

20 Aug 2014

Researchers use optical tweezers to measure how strongly parasites adhere to red blood cells

Malaria is a life-threatening disease caused by a parasite that invades one red blood cell after another. Little is known about this infection process because it happens so quickly, potentially explaining why there is currently no approved malaria vaccine.

20 Aug 2014

Dasatinib: Leukemia drug shows promise for treating skin, breast and other cancers

A leukemia drug called dasatinib shows promise for treating skin, breast and several other cancers, according to researchers at Loyola University Chicago Stritch School of Medicine.

20 Aug 2014

Research validates Myc inhibition as effective therapeutic strategy for glioma

Research led by the Vall d'Hebron Institute of Oncology (VHIO) evidence the most conclusive preclinical results to-date validating Myc inhibition as a therapeutic strategy in glioma - a highly agressive tumor type that notoriously outsmarts current anti-cancer therapies.

19 Aug 2014

Research shows long non-coding RNAs regulate circadian clocks

Researchers at UT Southwestern Medical Center have found a new way that internal body clocks are regulated by a type of molecule known as long non-coding RNA.

19 Aug 2014

New study shows how immune system developed in the course of evolution

Scientists at the Max Planck Institute of Immunobiology and Epigenetics (MPI-IE) in Freiburg re-activated expression of an ancient gene, which is not normally expressed in the mammalian immune system, and found that the animals developed a fish-like thymus.

19 Aug 2014

Thermo sensitive collagen hydrogel in dynamic culture enhances tissue-engineered peripheral nerve

Tissue engineering technologies offer new treatment strategies for the repair of peripheral nerve injury, but cell loss between seeding and adhesion to the scaffold remains inevitable.

19 Aug 2014

B Cell News and Research

EGFR biomarkers predict NSCLC response to vandetanib

Choroidal consequences differ between anti-VEGF therapies

Early intervention hope for childhood achromatopsia

CD157 important in malignant pleural mesothelioma

Trovagene announces results from clinical studies on urine-based diagnostic test for detection of HPV

Glenmark announces discovery and initiation of IND enabling studies of innovative bispecific antibody

Scientists suggest that type-1 and type-2 diabetes are result of same mechanism

Longitude and NovaQuest acquire California Cryobank

Analysis of Candida glabrata fungus mutations reveals new genes that confer anti-fungal tolerance

Newborn screening indicates that incidence of SCID is higher than previously believed

Researchers made important step towards creating medical nanorobots

Study helps explain why sleep becomes more fragmented with age

Houston Methodist researchers receive $1.6M from NIH to study pathological antibodies

Regulation of stem cells in zebrafish embryos results in surprising insights into Alzheimer's Disease

Researchers use optical tweezers to measure how strongly parasites adhere to red blood cells

Dasatinib: Leukemia drug shows promise for treating skin, breast and other cancers

Research validates Myc inhibition as effective therapeutic strategy for glioma

Research shows long non-coding RNAs regulate circadian clocks

New study shows how immune system developed in the course of evolution

Thermo sensitive collagen hydrogel in dynamic culture enhances tissue-engineered peripheral nerve

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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