Genome News and Research

RSS

Lower exosome component 2 expression protects against clinical SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that the lower expression of EXOSC2 human protein safeguards from clinical coronavirus disease 2019 (COVID-19). This protective effect was via the reduced EXOSC2 expression-associated suppression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication.

9 Mar 2022

Assessment of oligonucleotides as COVID-19 treatment

A recent study posted to the bioRxiv* pre-print server assessed the ability of oligonucleotides in preventing the development of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions.

8 Mar 2022

Whole-genome sequencing for determination of factors associated with critical COVID-19

In a recent study published in the journal Nature as an early release unedited manuscript, researchers conducted whole genomic sequencing (WGS) to ascertain factors contributing to critical coronavirus disease 2019 (COVID-19).

8 Mar 2022

A new view of SARS-CoV-2 genome structure

Researchers performed DMS mutational profiling with sequencing and DREEM clustering to determine the SARS-CoV-2 RNA secondary structure.

8 Mar 2022

How will mutations change the SARS-CoV-2 spike protein in the future?

A new Cells review discusses the factors that affect the function of the SARS-CoV-2 S protein and provides theoretical limits of this viral protein.

8 Mar 2022

Researchers come one step closer to reversing the destructive aging process in egg cells

Throughout much of the world, increasing numbers of women are delaying having their first child until they are in their late thirties, and even into their forties.

8 Mar 2022

Study explores immune escape mutations caused by prolonged viral shedding in immunocompromised COVID-19 patient

A new study examined a unique case of extended viral shedding in an immunocompromised patient that produced a series of SARS-CoV-2 immune escape mutations over a seven-month period.

8 Mar 2022

Effect of COVID-19 mRNA vaccine on in vitro glial cells of the brain studied by Raman spectroscopy and imaging

Researchers studied how the mRNA-based BNT162b2 COVID-19 vaccine altered the biochemical composition of glial and glioma brain cells in vitro.

8 Mar 2022

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Researchers recently unveiled the structure of programmed -1 ribosomal frameshifting pseudoknot of SARS-CoV-2.

8 Mar 2022

Recurrent mutations across the SARS-CoV-2 genome associated with long-term infections in immunodeficient patients

Researchers identified recurrent mutations in SARS-CoV-2.

8 Mar 2022

SARS-CoV-2 variant identification by RT-qPCR assays targeting mutations

In a recent study posted to the medRxiv* preprint server, researchers investigated the efficacy of diagnostic tests for identifying severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern (VOCs).

8 Mar 2022

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

In a recent study posted to the medRxiv*preprint server, a team of researchers from Israel developed and validated novel reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR) assays. The new assays enable the rapid and high throughput identification and differentiation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 and BA.2 variants.

8 Mar 2022

How have human organoids been used in research to study SARS-CoV-2?

In a recent review published in the journal Organoids, scientists have presented an overview on the use of human stem cell-derived organoids in understanding functionality and cellular tropism of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), a deadly beta-coronavirus responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic.

7 Mar 2022

Researchers investigate a predictive tool for the progression of rheumatoid arthritis

Predicting the future may be beyond our grasp, but what about predicting disease progression? Researchers in Japan have delved into the human genome to investigate a predictive tool for the progression of rheumatoid arthritis (RA), an inflammatory autoimmune disease showing progressive joint damage.

7 Mar 2022

Study offers insight into molecular biology of the brain in bipolar disorder patients

In a comprehensive study involving one of the largest-ever samples of post-mortem brains, scientists at the Lieber Institute for Brain Development, in collaboration with researchers at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, have pinpointed significant differences in gene expression in two specific regions of the brains of hundreds of patients who had bipolar disorder.

7 Mar 2022

World's largest genetic study reveals fresh details about severe Covid-19

The world's largest study of the genetics of critical Covid-19, involving more than 57,000 people, has revealed fresh details about some of the biological mechanisms behind the severe form of the disease.

7 Mar 2022

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Researchers from Columbia Engineering, Fiocruz's Center for Technological Development in Health and the Oswaldo Cruz Institute in Brazil, Memorial Sloan Kettering Cancer Center, and Rockefeller University recently reported that, by combining inhibitors of polymerases and exonucleases--enzymes that allow SARS-CoV-2 to reproduce--they were able to reduce SARS-CoV-2 replication 10 times more than when using just the polymerase inhibitors.

7 Mar 2022

Genome News and Research

Lower exosome component 2 expression protects against clinical SARS-CoV-2 infection

Assessment of oligonucleotides as COVID-19 treatment

Whole-genome sequencing for determination of factors associated with critical COVID-19

A new view of SARS-CoV-2 genome structure

How will mutations change the SARS-CoV-2 spike protein in the future?

Researchers come one step closer to reversing the destructive aging process in egg cells

Study explores immune escape mutations caused by prolonged viral shedding in immunocompromised COVID-19 patient

Effect of COVID-19 mRNA vaccine on in vitro glial cells of the brain studied by Raman spectroscopy and imaging

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Recurrent mutations across the SARS-CoV-2 genome associated with long-term infections in immunodeficient patients

SARS-CoV-2 variant identification by RT-qPCR assays targeting mutations

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

How have human organoids been used in research to study SARS-CoV-2?

Researchers investigate a predictive tool for the progression of rheumatoid arthritis

Study offers insight into molecular biology of the brain in bipolar disorder patients

World's largest genetic study reveals fresh details about severe Covid-19

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Delta and Omicron coinfections identified in France

Current progress in SARS-CoV-2 vaccine candidates

Combating COVID cytokine storm with targeted nucleic acid therapies

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Latest News