Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

MUSC scientists design novel antibody-based therapy to fight against cancer

Scientists at the Medical University of South Carolina (MUSC) have designed an antibody-based therapy that could target the functions of TGF-beta that cause cancer

12 Jan 2017

Childhood obesity starts in the womb?

There is incontrovertible evidence that some harmful drugs and toxins can affect lifelong health. For example, if women take certain drugs in pregnancy, such as thalidomide, there are well documented effects on lifelong health. These have obvious and dramatic effects on the child...

11 Jan 2017

Roswell Park researchers identify gene signatures that may help predict fatal prostate cancers

Standard therapy for prostate cancer, the third-leading cause of cancer-related deaths in American men, is based on blocking androgens, the male sex hormones.

11 Jan 2017

Elevated levels of brain protein linked to longer recovery period after concussion

Elevated levels of the brain protein tau following a sport-related concussion are associated with a longer recovery period and delayed return to play for athletes, according to a study published in the January 6, 2017 issue of Neurology, the medical journal of the American Academy of Neurology.

6 Jan 2017

Uterine microbiome study provides important insights into etiology of endometrial cancer

Endometrial cancer triggers remain elusive, despite continued research. But given the typical inflammatory profile in these cases, microbes in the uterine environment are suspected to play a role in the development of this disease.

6 Jan 2017

Giving polycystic kidney disease the bump

We launched this campaign at the beginning of October 2016. It's the first time that we've ever had a campaign of this size and scope. It's a European campaign in multiple languages that's coordinated by six of the organizations that represent PKD patients in Europe.

5 Jan 2017

IQWiG investigates benefit of biomarker tests to support decision on adjuvant chemotherapy

The German Institute for Quality and Efficiency in Health Care (IQWiG) investigated the benefit of biomarker tests to support the decision for or against adjuvant systemic chemotherapy in certain breast cancer patients, that is, women with primary hormone receptor-positive, HER2-negative breast cancer and up to 3 affected lymph nodes.

30 Dec 2016

Whitehead Institute researchers identify mechanism underlying cancer drug-resistance

The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs.

27 Dec 2016

Hospitals eliminate bedsore occurrence using early detection technology

Using technology adapted from NASA's Mars lander as part of a large-scale bedsore reduction program, over half of the 13 participating hospitals were able to eliminate the occurrence of new bedsores completely; an additional 3 hospitals achieved reductions ranging from 11% to 90%.

23 Dec 2016

UCLA-led research finds promising results for more personalized head and neck cancer treatment

Researchers have found that people with advanced head and neck squamous cell carcinoma and the KRAS-variant inherited genetic mutation have significantly improved survival when given a short course of the drug cetuximab in combination with standard chemotherapy and radiation.

23 Dec 2016

Tau biomarker could lead to early identification of Alzheimer's disease pathology

A discovery of high relevance in medical research will be published in Volume 55, number 4 of December 2016 of the prestigious "Journal of Alzheimer's Disease (JAD)", entitled "Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease".

22 Dec 2016

Groundbreaking research finds concussion biomarker in auditory system

The secret to reliably diagnosing concussions lies in the brain's ability to process sound, according to a new study by researchers from Northwestern University's Auditory Neuroscience Laboratory.

22 Dec 2016

Generative AAE can be radically new way to discover drugs on demand

Scientists at the Pharmaceutical Artificial Intelligence group of Insilico Medicine, Inc, today announced the publication of a seminal paper demonstrating the application of generative adversarial autoencoders (AAEs) to generating new molecular fingerprints on demand.

22 Dec 2016

Biomarker for oxidative stress plays key role in development of NAFLD, study shows

Diet-related diseases like non-alcoholic fatty liver disease (NAFLD) are known to have a major inflammatory component.

21 Dec 2016

Hormone receptor could be potential biomarker for gastric cancer, research shows

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, the Veterans Affairs Medical Center in Miami, and Shantou University Medical College in China, have shown that the hormone receptor GHRH-R could be a potential biomarker for gastric cancer, enabling earlier diagnoses and better staging.

21 Dec 2016

Presence of tumor DNA in blood linked to poor outcomes in pancreatic cancer patients

The presence of circulating tumor DNA (ctDNA) isolated from blood samples of patients with pancreatic adenocarcinoma was associated with poor outcomes.

19 Dec 2016

Researchers explore kidney biomarkers to track lupus progression

Lupus, a chronic autoimmune disease, can wreak havoc on an affected individual's body through inflammation, pain and even damage of the skin, joints and organs.

16 Dec 2016

Study suggests potential blood-based marker to predict oropharyngeal cancer recurrence

A new study suggests the possibility of predicting at its earliest stages when a type of head and neck cancer will come back.

16 Dec 2016

Researchers identify attractive drug candidate to target glioma tumors

In a paper published today in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

16 Dec 2016

Western diet during pregnancy may increase obesity risk in offspring

Diet composition around the time of pregnancy may influence whether offspring become obese, according to a new study using animal models at The Scripps Research Institute (TSRI).

15 Dec 2016

Biomarker News and Research

Further Reading

MUSC scientists design novel antibody-based therapy to fight against cancer

Childhood obesity starts in the womb?

Roswell Park researchers identify gene signatures that may help predict fatal prostate cancers

Elevated levels of brain protein linked to longer recovery period after concussion

Uterine microbiome study provides important insights into etiology of endometrial cancer

Giving polycystic kidney disease the bump

IQWiG investigates benefit of biomarker tests to support decision on adjuvant chemotherapy

Whitehead Institute researchers identify mechanism underlying cancer drug-resistance

Hospitals eliminate bedsore occurrence using early detection technology

UCLA-led research finds promising results for more personalized head and neck cancer treatment

Tau biomarker could lead to early identification of Alzheimer's disease pathology

Groundbreaking research finds concussion biomarker in auditory system

Generative AAE can be radically new way to discover drugs on demand

Biomarker for oxidative stress plays key role in development of NAFLD, study shows

Hormone receptor could be potential biomarker for gastric cancer, research shows

Presence of tumor DNA in blood linked to poor outcomes in pancreatic cancer patients

Researchers explore kidney biomarkers to track lupus progression

Study suggests potential blood-based marker to predict oropharyngeal cancer recurrence

Researchers identify attractive drug candidate to target glioma tumors

Western diet during pregnancy may increase obesity risk in offspring

Industry Focus eBook - Protein Analysis (3rd edition) eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo