Preclinical News and Research

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CHMP provides positive opinion to Cabometyx for previously-treated patients with hepatocellular carcinoma

Ipsen announced today that the Committee for Medicinal Products for Human Use, the scientific committee of the European Medicines Agency, provided a positive opinion for Cabometyx (cabozantinib) as a monotherapy for the treatment of hepatocellular carcinoma in adults who have been previously treated with sorafenib.

21 Sep 2018

Dopamine neurons may involve in conditions ranging from Parkinson's disease to schizophrenia

Dopamine neurons are located in the midbrain, but their tendril-like axons can branch far into the higher cortical areas, influencing how we move and how we feel.

21 Sep 2018

LineaRx signs agreement with Takis/Evvivax to develop linear-DNA based anti-cancer vaccines

Applied DNA Sciences Inc. announced today that LineaRx, Inc., its wholly-owned subsidiary focused on next-generation biotherapeutics, has signed a Joint Development Agreement with Takis S.R.L. and Evvivax S.R.L., biotechnology companies focused on the discovery and development of DNA based anti-cancer vaccines for the human and animal markets, respectively.

20 Sep 2018

MILabs' VECTor6 system wins Commercial Innovation Award at WMIC 2018

MILabs is pleased to announce that its new VECTor6 with Broadband Photon Tomography technique has received the Commercial Innovation Award at the World Molecular Imaging Congress (WMIC) in Seattle September 12th-15th, 2018.

20 Sep 2018

Research finds physical connection between the brain's fluid reservoirs and meningeal lymphatics

PureTech Health plc, an advanced biopharmaceutical company developing novel medicines for dysfunctions of the Brain-Immune-Gut Axis, today notes the publication of research in Nature Neuroscience that identifies the physical connection between the brain's fluid reservoirs and the meningeal lymphatics, through which immune cells traffic out of the central nervous system.

18 Sep 2018

UNIST and Ulsan initiate research collaboration to develop human organs-on-chips

UNIST and Ulsan will initiate a research collaboration to develop human organs-on-chips in hoping to reduce the time and cost for new drug discovery.

18 Sep 2018

Alivio Therapeutics receives DoD grant to advance development of new therapy for IC/BPS

Alivio Therapeutics, an affiliate of PureTech Health plc developing therapies to treat inflammatory disorders through targeted disease immunomodulation, today announced a $3.3 million U.S. Department of Defense Technology/Therapeutic Development Award to advance Alivio's product candidate, ALV-107, for the treatment of interstitial cystitis/bladder pain syndrome with Hunner's lesions.

12 Sep 2018

Inhaled form of high blood pressure drug has potential to treat anxiety, pain

An inhaled form of a high blood pressure medication has potential to treat certain types of anxiety as well as pain, according to a new study by the Centre for Addiction and Mental Health.

11 Sep 2018

MILabs' new Broadband Photon Tomography selected for Innovation of the Year award

MILabs is pleased to announce that its new Broadband Photon Tomography technique has been nominated for the Innovation of the Year 2018 award by the World Molecular Imaging Society (WMIS) board of trustees.

11 Sep 2018

Researchers develop new generation of pain medications

Researchers from Charité - Universitätsmedizin Berlin and the Zuse Institute Berlin have developed a new generation of pain medications.

7 Sep 2018

3D-printed polymer implant samples pass preclinical tests at Ilizarov Orthopedic Center

Russian scientists successfully tested biodegradable tibia implants with bioactive coatings out of polylactic acid and calcium phosphate, which might shorten the treatment period by two-four times compared to current world standards.

7 Sep 2018

Founder and Chairman of MR Solutions shortlisted for 2018 NatWest Great British Entrepreneur Awards

Founder and Chairman, Dr David Taylor, of Guildford based MR Solutions has been shortlisted as an Innovation Entrepreneur of the Year for London and the South East in the 2018 NatWest Great British Entrepreneur Awards.

From MR Solutions 7 Sep 2018

New study aims to understand why skin grafts have high rate of rejection

When it comes to transplant rejection, some organs are far trickier than others. Some transplantable organs, such as the liver, are readily accepted by the recipient's immune system, rarely triggering an immune response and rejection

7 Sep 2018

Verastem doses first patient in Phase I/II clinical trial of duvelisib in combination with venetoclax

Verastem, Inc., operating as Verastem Oncology, a biopharmaceutical company focused on developing and commercializing medicines to improve the survival and quality of life of cancer patients, today announced dosing of the first patient in a multicenter Phase I/II clinical trial at the Dana-Farber/Harvard Cancer Center of duvelisib in combination with venetoclax in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

6 Sep 2018

BeiGene collaborates with SpringWorks to evaluate new combinational therapy for solid tumors

BeiGene, Ltd., a commercial-stage biopharmaceutical company focused on developing and commercializing innovative molecularly-targeted and immuno-oncology drugs for the treatment of cancer, and SpringWorks Therapeutics, a clinical-stage rare disease and oncology company focused on sourcing and developing innovative treatments for underserved patient populations, announced today that the companies have entered into a global clinical collaboration agreement to evaluate the safety, tolerability and preliminary efficacy of combining BeiGene's investigational RAF dimer inhibitor, lifirafenib and SpringWorks Therapeutics' investigational MEK inhibitor, PD-0325901, in patients with advanced solid tumors.

6 Sep 2018

Preclinical News and Research

CHMP provides positive opinion to Cabometyx for previously-treated patients with hepatocellular carcinoma

Dopamine neurons may involve in conditions ranging from Parkinson's disease to schizophrenia

LineaRx signs agreement with Takis/Evvivax to develop linear-DNA based anti-cancer vaccines

MILabs' VECTor6 system wins Commercial Innovation Award at WMIC 2018

Research finds physical connection between the brain's fluid reservoirs and meningeal lymphatics

UNIST and Ulsan initiate research collaboration to develop human organs-on-chips

Alivio Therapeutics receives DoD grant to advance development of new therapy for IC/BPS

Inhaled form of high blood pressure drug has potential to treat anxiety, pain

MILabs' new Broadband Photon Tomography selected for Innovation of the Year award

Researchers develop new generation of pain medications

3D-printed polymer implant samples pass preclinical tests at Ilizarov Orthopedic Center

Founder and Chairman of MR Solutions shortlisted for 2018 NatWest Great British Entrepreneur Awards

New study aims to understand why skin grafts have high rate of rejection

Verastem doses first patient in Phase I/II clinical trial of duvelisib in combination with venetoclax

BeiGene collaborates with SpringWorks to evaluate new combinational therapy for solid tumors

MILabs completes installation of new X-ray CT system at University of Sydney

Bee venom may be effective treatment for eczema

UA researchers receive $4.4 million grant to focus on idiopathic pulmonary fibrosis

Effective vaccines for world's most prevalent infectious diseases are missing from pipeline

New strategy shows promise to tap earliest Alzheimer's changes in the brain

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