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High-resolution whole-cortex imaging reveals neurovascular dynamics in awake mice

Neurovascular coupling (NVC) is the dynamic regulation of cerebral blood flow in response to neural activity. Specifically, when neurons become active, nearby blood vessels dilate to increase blood supply, thereby meeting the heightened energy demands associated with neural activity.

24 Jul 2025

Ibogaine treatment shows major breakthrough for veterans with brain injuries

Now, Stanford Medicine researchers have discovered that the plant-based psychoactive drug ibogaine, when combined with magnesium to protect the heart, safely and effectively reduces PTSD, anxiety and depression and improves functioning in veterans with TBI.

24 Jul 2025

Penn State team investigates the neural basis of nightmares and mental health

Dreams, and likely nightmares, are experienced universally across humans and animals, but neuroscientists still do not know why.

24 Jul 2025

Intranasal insulin safely and effectively reaches key memory regions of the brain

A groundbreaking brain imaging study from Wake Forest University School of Medicine confirms a vital step toward new Alzheimer's disease treatments: Intranasal insulin, delivered via a simple nasal spray, safely and effectively reaches key memory regions of the brain in older adults.

23 Jul 2025

UC Davis researchers pioneer safer gene therapy for vision loss

The UC Davis Department of Ophthalmology has received a five-year, $3.6 million grant from the National Eye Institute to explore a new way to treat vision loss using gene therapy.

22 Jul 2025

Mapping metformin’s kidney effects through spatial multi-omics

Metformin is a widely used first-line therapy for type 2 diabetes, and studies increasingly point to its protective effects on the kidney.

22 Jul 2025

Optimists think alike: Brain scans reveal shared visions of the future

Researchers found that optimistic individuals share similar patterns of brain activity when imagining future events, especially distinguishing positive from negative scenarios. This neural convergence may help explain why optimists experience greater emotional clarity and social connection.

22 Jul 2025

Astrocytes play key role in coordinating neurons for visual information

Cells called astrocytes are about as abundant in the brain as neurons, but scientists have spent much less time figuring out how they contribute to brain functions.

22 Jul 2025

APOE ε4 variant reveals hidden risk factors beyond Alzheimer’s

Researchers discovered that people carrying the APOE ε4 gene variant share a unique immune-related protein signature across their blood, brain, and cerebrospinal fluid—regardless of neurodegenerative disease diagnosis. This signature reveals a fundamental, disease-independent vulnerability linked to APOE ε4, reframing our understanding of genetic risk in conditions like Alzheimer's, Parkinson’s, ALS, and FTD.

21 Jul 2025

The brain resolves sensory overload through rhythmic sampling

Recent research shows that your brain doesn't pay attention in one smooth stream-instead, it switches focus in quick bursts, about 8 times per second.

21 Jul 2025

Overuse injuries spark lasting pain and mood changes through inflammation, rat study finds

Repetitive reaching tasks in mature female rats triggered persistent pain-like and sickness behaviors linked to a surge in IL-6-driven inflammation throughout muscles, blood, and the brain. These findings reveal how overuse injuries provoke both physical and mood-related symptoms through a neuroimmune cascade.

20 Jul 2025

Blocking GAPDH aggregation protects brain cells and opens new path for stroke therapy

In a mouse model of acute ischemic stroke, researchers showed that inhibiting the aggregation of GAPDH, either genetically or with a novel peptide, significantly reduced brain damage and improved neurological function. The findings highlight GAPDH aggregation as a promising therapeutic target for stroke intervention.

20 Jul 2025

Understanding brain activity during sleep to detect early neurological changes

"Complex processes are going on in the brain when we sleep," says Dr Karolina Armonaitė, a neuroscientist from Kaunas University of Technology, Lithuania. According to her, a more precise understanding of what happens in different areas of the cerebral cortex during sleep can help diagnose sleep disorders and neurological diseases more accurately.

18 Jul 2025

Ripple activity in the brain helps organize and store episodic memories

A research team from the Faculty of Psychology at the University of Barcelona, the UB Institute of Neurosciences (UBneuro) and the Bellvitge Biomedical Research Institute (IDIBELL) has identified, for the first time in humans, and in a realistic environment, a key neurophysiological mechanism in memory formation: ripple-type brain waves —high-frequency electrical oscillations that mark and organize the different episodes or fragments of information that the brain stores as memories.

17 Jul 2025

New tech could revolutionize neurodegenerative disease research and AI

When electrical activity travels across the brain, it moves like ripples on a pond. The motion of these "brain waves," first observed in the 1920s, can now be seen more clearly than ever before thanks to instruments and techniques created by a Stanford-led team.

17 Jul 2025

Shared brain circuit drives opposite mating behaviors in male and female mice

In animals with social structures, the drive to reproduce is a complex process; governed by the brain, it's influenced by both internal cues such as hormones and external factors such as interactions with potential mates.

16 Jul 2025

Ultra-processed foods threaten brain health in kids and teens, review warns

Children, adolescents, and unborn babies exposed to high levels of ultra-processed foods (UPFs) face increased risks of impaired brain development, cognitive deficits, and long-term mental health challenges. The review underscores how UPF-driven changes in reward pathways, nutrient deficits, inflammation, and the gut–brain axis can have lasting impacts across generations.

13 Jul 2025