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Groundbreaking ALS platform trial accelerates research and drug testing

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with few treatment options. Since 2018, the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, has been working with national and international stakeholders to accelerate ALS research by launching the first platform trial in ALS to simultaneously test multiple drugs using shared trial infrastructure and placebo data.

17 Feb 2025

MARBLE algorithm decodes brain activity to identify universal mental patterns

In the parable of the blind men and the elephant, several blind men each describe a different part of an elephant they are touching – a sharp tusk, a flexible trunk, or a broad leg – and disagree about the animal's true nature.

17 Feb 2025

Gene therapy shows promise in treating SCN1B-linked epileptic encephalopathies

Dravet syndrome and other developmental epileptic encephalopathies are rare but devastating conditions that cause a host of symptoms in children, including seizures, intellectual disability, and even sudden death.

14 Feb 2025

Researchers uncover the brain mechanism behind ketamine's action

Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic.

14 Feb 2025

Harvard researchers map 70,000 synaptic connections in rat brain

Harvard researchers have mapped and catalogued more than 70,000 synaptic connections from about 2,000 rat neurons, using a silicon chip capable of recording small yet telltale synaptic signals from a large number of neurons.

14 Feb 2025

How immune cells and neurons secretly shape brain health, behavior, and disease

Scientists explore how the immune and nervous systems constantly communicate, influencing brain diseases, behavior, and repair while shaping responses to environmental factors like sleep, diet, and pollution.

13 Feb 2025

Breakthrough discovery reveals key role of ovoid cells in object recognition memory

Take a look around your home and you'll find yourself surrounded by familiar comforts-photos of family and friends on the wall, well-worn sneakers by the door, a shelf adorned with travel mementos.

13 Feb 2025

New insights could help prevent peripheral neuropathy or slow disease onset

An increase in high-fat, high-fructose foods in people's diets has contributed to a dramatic increase in type 2 diabetes.

12 Feb 2025

Cerebral cortex plays key role in memory and novelty detection

The cerebral cortex is the largest part of a mammal's brain, and by some measures the most important. In humans in particular, it's where most things happen-like perception, thinking, memory storage and decision-making.

10 Feb 2025

New model reveals how the brain processes sensory cues during decision making

A new mathematical model sheds light on how the brain processes different cues, such as sights and sounds, during decision making.

10 Feb 2025

Bionic skin technology provides advanced tactile recognition and visualization capabilities

A new publication from Opto-Electronic Advances; DOI 10.29026/oea.2025.240152, discusses how multi-photon bionic skin realizes high-precision haptic visualization for reconstructive perception.

8 Feb 2025

New discovery links brain and muscle cells in signal transmission

Our biceps and our brain cells may have more in common than previously thought.

8 Feb 2025

Neurostimulation improves movement in adults with spinal muscle atrophy

A new drug-free, minimally invasive intervention targets the root cause of progressive loss of neural function in spinal muscle atrophy (SMA), an inherited neuromuscular disease.

5 Feb 2025

Alzheimer’s disease may leave early signs in the gut, study finds

Scientists used high-resolution 3D X-ray imaging to uncover major structural and immune changes in the gut of Alzheimer's disease models, suggesting a potential early biomarker.

3 Feb 2025

3D-printed brain-like model helps unlock neuron growth secrets

Key cells in the brain, neurons, form networks by exchanging signals, enabling the brain to learn and adapt at incredible speed.

31 Jan 2025

Researchers create high-performance artificial neurons for advanced perception systems

Artificially engineered biological processes, such as perception systems, remain an elusive target for organic electronics experts due to the reliance of human senses on an adaptive network of sensory neurons, which communicate by firing in response to environmental stimuli.

30 Jan 2025